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2-Benzoxazolone structure, CAS 59-49-4

2-Benzoxazolone

CAS Number59-49-4

Synonyms1,3-Benzoxazol-2(3H)-one; Benzoxazolinone; MFCD00005716; 2-Benzoxaxolol; Benzoxazole-2-ol; 2-Benzoxazolol; BENZOXAZOLONE; 3H-benzoxazol-2-one; 2(3H)-Benzoxazolone; 2-BENZOXAZOLONE; USAF ek-5429; 2,3-dihydrobenzoxazol-2-one; benzoxazol-2-one; 2-oxo-2,3-dihydrobenzoxazole; EINECS 200-430-0; 2-Benzoxazolinone; 3H-benzooxazol-2-one

Molecular FormulaC14H10N2O3

Molecular Weight254.247

Purity98%

Density1.3±0.1 g/cm3

Boiling Point299ºC at 760 mmHg

Melting Point137-139 °C(lit.)

Flash Point

AppearanceSlightly beige powder

EINECS200-430-0

MSDSChineseEnglish

SymbolTransport

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Cat. No.: 2A-9002484 Purity: 98%
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Quality Control of [ 59-49-4 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number59-49-4
Catalog No.2A-9002484
Chinese Name2-苯并噁唑酮
Synonyms1,3-Benzoxazol-2(3H)-one; Benzoxazolinone; MFCD00005716; 2-Benzoxaxolol; Benzoxazole-2-ol; 2-Benzoxazolol; BENZOXAZOLONE; 3H-benzoxazol-2-one; 2(3H)-Benzoxazolone; 2-BENZOXAZOLONE; USAF ek-5429; 2,3-dihydrobenzoxazol-2-one; benzoxazol-2-one; 2-oxo-2,3-dihydrobenzoxazole; EINECS 200-430-0; 2-Benzoxazolinone; 3H-benzooxazol-2-one
Molecular FormulaC14H10N2O3
Molecular Weight254.247
Purity98
Density1.3±0.1 g/cm3
Boiling Point299ºC at 760 mmHg
Melting Point137-139 °C(lit.)
AppearanceSlightly beige powder
Water Solubilitysoluble in hot water
Storage ConditionThis product should be kept sealed.
Application2-Benzoxazolinone is an anti-Leishmania reagent with an LC50 of 40 μg/mL against L. donovani [1]. Its derivatives have antimicrobial activity against a range of Gram-positive and -negative bacteria [3
EINECS200-430-0
HTC2934999090
MDL NumberMFCD00092666
SMILESO=c1[nH]c2ccccc2o1
InChIInChI=1S/C7H5NO2/c9-7-8-5-3-1-2-4-6(5)10-7/h1-4H,(H,8,9)
InChI KeyASSKVPFEZFQQNQ-UHFFFAOYSA-N
Hazard SymbolsTransport
Risk CodesR22
Safety DescriptionS24/25
MSDSmsds/2484_1_59_49_4.pdf
Bioactivity2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani[1]. A building block in chemical synthesis. 1,3-Benzoxazol-2(3H)-one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts[3]. Derivatives as anti-quorum sensing agent[4]. Related Catalog Signaling Pathways >> Anti-infection >> Parasite Natural Products >> Alkaloid Research Areas >> Infection Target LC50: 40 μg/mL (L. donovani)[1] In Vitro 2-Benzoxazolinone (0.1-5 mM) induces oxidative stress in mung bean through generation of ROS and upregulation of activities of various scavenging enzymes[2]. References [1]. Kapil A, et al. Leishmanicidal activity of 2-benzoxazolinone from Acanthus illicifolius in vitro. Planta Med. 1994 Apr;60(2):187-8. [2]. Batish DR, et al. 2-Benzoxazolinone (BOA) induced oxidative stress, lipid peroxidation and changes in some antioxidant enzyme activities in mung bean (Phaseolus aureus). Plant Physiology and Biochemistry 44(11-12):819-27 [3]. Krawiecka M, et al. Synthesis and biological activity of novel series of 1,3-benzoxazol-2(3H)-one derivatives. Acta Pol Pharm. 2013 Mar-Apr;70(2):245-53. [4]. Miandji AM, et al. Synthesis and biological activities of some 1,3-benzoxazol-2(3H)-one derivatives as anti-quorum sensing agents. Arzneimittelforschung. 2012 Jul;62(7):330-4. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 299ºC at 760 mmHg Melting Point 137-139 °C(lit.) Molecular Formula C7H5NO2 Molecular Weight 135.120 Flash Point 160 °C Exact Mass 135.032028 PSA 46.00000 LogP 1.16 Index of Refraction 1.586 InChIKey ASSKVPFEZFQQNQ-UHFFFAOYSA-N SMILES O=c1[nH]c2ccccc2o1 Water Solubility soluble in hot water
Use of2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani[1]. A building block in chemical synthesis. 1,3-Benzoxazol-2(3H)-one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts[3]. Derivatives as anti-quorum sensing agent[4]. Properties Name 2-Benzoxazolinone Synonym More Synonyms 2-Benzoxazolinone Biological Activity Description 2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani[1]. A building block in chemical synthesis. 1,3-Benzoxazol-2(3H)-one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts[3]. Derivatives as anti-quorum sensing agent[4]. Related Catalog Signaling Pathways >> Anti-infection >> Parasite Natural Products >> Alkaloid Research Areas >> Infection LC50: 40 μg/mL (L. donovani)[1] References [1]. Kapil A, et al. Leishmanicidal activity of 2-benzoxazolinone from Acanthus illicifolius in vitro. Planta Med. 1994 Apr;60(2):187-8. [2]. Batish DR, et al. 2-Benzoxazolinone (BOA) induced oxidative stress, lipid peroxidation and changes in some antioxidant enzyme activities in mung bean (Phaseolus aureus). Plant Physiology and Biochemistry 44(11-12):819-27 [3]. Krawiecka M, et al. Synthesis and biological activity of novel series of 1,3-benzoxazol-2(3H)-one derivatives. Acta Pol Pharm. 2013 Mar-Apr;70(2):245-53. [4]. Miandji AM, et al. Synthesis and biological activities of some 1,3-benzoxazol-2(3H)-one derivatives as anti-quorum sensing agents. Arzneimittelforschung. 2012 Jul;62(7):330-4. Chemical & Physical Properties Molecular Formula C7H5NO2 Exact Mass 135.032028 PSA 46.00000 Index of Refraction 1.586 InChIKey ASSKVPFEZFQQNQ-UHFFFAOYSA-N Water Solubility soluble in hot water
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 0.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available
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