CAS Number674-26-0
Synonyms(3RS)-mevalonolactone; MEVALONIC LACTONE; (±)-MEVALONOLACTONE; EINECS 211-615-0; DL-MEVALOLACTONE; MFCD00006648; DL-mevalonic acid lactone; D,L-MEVELONIC ACID LACTONE; MEVALONIC ACID LACTONE,DL; (RS)-mevalonolactone; (S/R)-mevalonolactone
Molecular FormulaC6H10O3
Molecular Weight130.14
Purity~97 (titration)%
Density1.189 g/cm3
Boiling Point145-150 °C5 mm Hg(lit.)
Melting Point28 °C(lit.)
AppearanceMoist light yellow to off-white solid
EINECS211-615-0
Symbol
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| Chemical & Physical Properties | |
|---|---|
| CAS Number | 674-26-0 |
| Catalog No. | 2A-9024822 |
| Chinese Name | DL-甲瓦龙酸内酯 |
| Synonyms | (3RS)-mevalonolactone; MEVALONIC LACTONE; (±)-MEVALONOLACTONE; EINECS 211-615-0; DL-MEVALOLACTONE; MFCD00006648; DL-mevalonic acid lactone; D,L-MEVELONIC ACID LACTONE; MEVALONIC ACID LACTONE,DL; (RS)-mevalonolactone; (S/R)-mevalonolactone |
| Molecular Formula | C6H10O3 |
| Molecular Weight | 130.14 |
| Purity | ~97 (titration) |
| Density | 1.189 g/cm3 |
| Boiling Point | 145-150 °C5 mm Hg(lit.) |
| Melting Point | 28 °C(lit.) |
| Appearance | Moist light yellow to off-white solid |
| Storage Condition | Store in an airtight container in a cool, dry plac |
| Application | DL-Mevalonolactone ((±) -Mevalonolactone; Mevalolactone) is the delta-lactone form of mevalonate, a precursor of the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) can reduce mitochondrial m |
| EINECS | 211-615-0 |
| HTC | 2932999099 |
| PubChem ID | 24896934 |
| MDL Number | MFCD00006648 |
| SMILES | CC1(O)CCOC(=O)C1 |
| InChI | 1S/C6H10O3/c1-6(8)2-3-9-5(7)4-6/h8H,2-4H2,1H3 |
| InChI Key | JYVXNLLUYHCIIH-UHFFFAOYSA-N |
| Beilstein/REAXYS | 80960 |
| NACRES Code | NA.25 |
| UNSPSC | 12352108 |
| Hazard Symbols | transportation |
| MSDS | msds/24822_1_674_26_0.pdf |
| Bioactivity | DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Domingos SR, et al. On the structural intricacies of a metabolic precursor: Direct spectroscopic detection of water-induced conformational reshaping of mevalonolactone. J Chem Phys. 2017 Sep 28;147(12):124310. [2]. Cecatto C, et al. Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria. Neurochem Int. 2017 Sep;108:133-145. Chemical & Physical Properties Density 1.189 g/cm3 Boiling Point 145-150 °C5 mm Hg(lit.) Melting Point 28 °C(lit.) Molecular Formula C6H10O3 Molecular Weight 130.14200 Flash Point >230 °F Exact Mass 130.06300 PSA 46.53000 LogP 0.07440 Index of Refraction n20/D 1.473(lit.) InChIKey JYVXNLLUYHCIIH-UHFFFAOYSA-N SMILES CC1(O)CCOC(=O)C1 Storage condition 2-8°C Stability Hygroscopic |
| Use of | DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2]. Properties Articles28 Name DL-Mevalonolactone Synonym More Synonyms DL-Mevalonolactone Biological Activity Description DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Domingos SR, et al. On the structural intricacies of a metabolic precursor: Direct spectroscopic detection of water-induced conformational reshaping of mevalonolactone. J Chem Phys. 2017 Sep 28;147(12):124310. [2]. Cecatto C, et al. Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria. Neurochem Int. 2017 Sep;108:133-145. Chemical & Physical Properties Molecular Formula C6H10O3 Exact Mass 130.06300 PSA 46.53000 LogP 0.07440 InChIKey JYVXNLLUYHCIIH-UHFFFAOYSA-N SMILES CC1(O)CCOC(=O)C1 Stability Hygroscopic |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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