CAS Number672-87-7
SynonymsMFCD00064201; (S)-alpha-Methyltyrosine; α-METHYL-L-P-TYROSINE; alpha-methyl-L-tyrosine; EINECS 211-599-5
Molecular FormulaC10H13NO3
Molecular Weight195.22
Purity98.00%
Density1.283g/cm3
Boiling Point383.7ºC at 760 mmHg
Melting Point320-340°C dec.
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 672-87-7 |
| Catalog No. | 2A-9024816 |
| Chinese Name | α-甲基-L-酪氨酸 |
| Synonyms | MFCD00064201; (S)-alpha-Methyltyrosine; α-METHYL-L-P-TYROSINE; alpha-methyl-L-tyrosine; EINECS 211-599-5 |
| Molecular Formula | C10H13NO3 |
| Molecular Weight | 195.22 |
| Purity | 98.00 |
| Density | 1.283g/cm3 |
| Boiling Point | 383.7ºC at 760 mmHg |
| Melting Point | 320-340°C dec. |
| Storage Condition | -20℃, avoid light, ventilated and dry place |
| Application | Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine has anti-inflammatory and anti-ulcer effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very ef |
| HTC | 2922509090 |
| PubChem ID | 329750462 |
| MDL Number | MFCD00064201 |
| SMILES | C[C@](N)(Cc1ccc(O)cc1)C(O)=O |
| InChI | 1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1 |
| InChI Key | NHTGHBARYWONDQ-JTQLQIEISA-N |
| Beilstein/REAXYS | 2368400 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | transportation |
| MSDS | msds/24816_1_672_87_7.pdf |
| Bioactivity | Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity[1]. Metyrosine is a very effective agent for blood pressure control[2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Immunology/Inflammation >> COX In Vitro Metyrosine acts by inhibiting tyrosine hydroxylase, thus causing depletion of adrenal stores of catecholamines[2]. In Vivo Metyrosine (50-200 mg/kg; i.p.) reduces carrageenan inflammation[1]. Metyrosine (50-200 mg/kg; i.p.) shows antiulcerative activity is 87.7%, 93.7% and 95.5% for 50, 100 and 200 mg/kg doses of metyrosine, respectively[1]. Animal Model: Male albino Wistar rats (carrageenan-induced rat paw edema)[2] Dosage: 50, 100 or 200 mg/kg Administration: I.p. Result: Reduced carrageenan inflammation at 50, 100 and 200 mg/kg doses (40%, 67% and 87%, respectively, at 4 h). References [1]. Albayrak A, Polat B, Cadirci E, et al. Gastric anti-ulcerative and anti-inflammatory activity of metyrosine in rats. Pharmacol Rep. 2010;62(1):113‐119. [2]. Garg MK, et al. Medical management of pheochromocytoma: Role of the endocrinologist. Indian J Endocrinol Metab. 2011;15 Suppl 4(Suppl4):S329‐S336. Chemical & Physical Properties Density 1.283g/cm3 Boiling Point 383.7ºC at 760 mmHg Melting Point 320-340°C dec. Molecular Formula C10H13NO3 Molecular Weight 195.21500 Flash Point 185.9ºC Exact Mass 195.09000 PSA 83.55000 LogP 1.43700 Index of Refraction 1.599 InChIKey NHTGHBARYWONDQ-JTQLQIEISA-N SMILES CC(N)(Cc1ccc(O)cc1)C(=O)O Storage condition −20°C |
| Use of | Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity[1]. Metyrosine is a very effective agent for blood pressure control[2]. Properties Articles29 Name α-methyl-L-tyrosine Synonym More Synonyms Metyrosine Biological Activity Description Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity[1]. Metyrosine is a very effective agent for blood pressure control[2]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Immunology/Inflammation >> COX In Vitro Metyrosine acts by inhibiting tyrosine hydroxylase, thus causing depletion of adrenal stores of catecholamines[2]. References [1]. Albayrak A, Polat B, Cadirci E, et al. Gastric anti-ulcerative and anti-inflammatory activity of metyrosine in rats. Pharmacol Rep. 2010;62(1):113‐119. [2]. Garg MK, et al. Medical management of pheochromocytoma: Role of the endocrinologist. Indian J Endocrinol Metab. 2011;15 Suppl 4(Suppl4):S329‐S336. Chemical & Physical Properties Molecular Formula C10H13NO3 Exact Mass 195.09000 PSA 83.55000 LogP 1.43700 Index of Refraction 1.599 InChIKey NHTGHBARYWONDQ-JTQLQIEISA-N |
| Tax Rebate | 13.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Product name: Purity: 95.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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