CAS Number613-93-4
SynonymsN-MethylbenzaMide 10GR; n-methylbenzenecarboxamide; N-Methylbenzamide; N-Methylbenzenamide; n-methyl-benzamid; N-methyl benzamide; EINECS 210-362-3; MFCD00011642
Molecular FormulaC6H5CON(OCH3)CH3
Molecular Weight165.19
Purity98%
Density1.0±0.1 g/cm3
Boiling Point70 °C/0.1 mmHg (lit.)
Melting Point76-78 °C(lit.)
Appearanceliquid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 613-93-4 |
| Catalog No. | 2A-9024192 |
| Chinese Name | N-甲基苯甲酰胺 |
| Synonyms | N-MethylbenzaMide 10GR; n-methylbenzenecarboxamide; N-Methylbenzamide; N-Methylbenzenamide; n-methyl-benzamid; N-methyl benzamide; EINECS 210-362-3; MFCD00011642 |
| Molecular Formula | C6H5CON(OCH3)CH3 |
| Molecular Weight | 165.19 |
| Purity | 98 |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 70 °C/0.1 mmHg (lit.) |
| Melting Point | 76-78 °C(lit.) |
| Appearance | liquid |
| Storage Condition | Storage: Seal the container and store it in a seal |
| Application | N-Methylbenzamide is a potent inhibitor of phosphodiesterase 10A (PDE10A). N-Methylbenzamide has anticancer activity. |
| PubChem ID | 24861315 |
| MDL Number | MFCD00075320 |
| SMILES | CON(C)C(=O)c1ccccc1 |
| InChI | 1S/C9H11NO2/c1-10(12-2)9(11)8-6-4-3-5-7-8/h3-7H,1-2H3 |
| InChI Key | UKERDACREYXSIV-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| MSDS | msds/24192_1_613_93_4.pdf |
| Bioactivity | N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor. N-Methylbenzamide has anti-cancer activity[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Target PDE10A In Vivo N-Methylbenzamide (compound 21; 100-800 mg/kg; ip; for 17 days) is active against tumor in donor female BDF mice (18-23 g)[2]. References [1]. Kilburn JP, et al. N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase 10A (PDE10A) inhibitors. Bioorg Med Chem. 2013 Oct 1;21(19):6053-62. [2]. Gate, E. N., et al. Structural studies on bioactive compounds. 4. A structure-antitumor activity study on analogs of N-methylformamide. Journal of Medicinal Chemistry, 1986, 29(6), 1046-1052. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 254.9±23.0 °C at 760 mmHg Melting Point 76-78 °C(lit.) Molecular Formula C8H9NO Molecular Weight 135.163 Flash Point 145.6±11.9 °C Exact Mass 135.068420 PSA 29.10000 LogP 1.66 Vapour Pressure 0.0±0.5 mmHg at 25°C Index of Refraction 1.519 |
| Use of | N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor. N-Methylbenzamide has anti-cancer activity[1][2]. Properties Name n-methylbenzamide Synonym More Synonyms 1MVR Biological Activity Description N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor. N-Methylbenzamide has anti-cancer activity[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) References [1]. Kilburn JP, et al. N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase 10A (PDE10A) inhibitors. Bioorg Med Chem. 2013 Oct 1;21(19):6053-62. Chemical & Physical Properties Molecular Formula C8H9NO Exact Mass 135.068420 PSA 29.10000 Index of Refraction 1.519 |
| Transport Info | Product name: N-Methylbenzamide |
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