CAS Number611-40-5
SynonymsTectorigenin 7-glucoside; 4',5-Dihydro-6-methoxy-7-(o-glucoside)isoflavone; 5-Hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4-oxo-4H-chromen-7-yl β-D-glucopyranoside; Shekanin; tectoridin
Molecular FormulaC22H22O11
Molecular Weight462.40
Purity≥95.0 (HPLC)%
Density1.6±0.1 g/cm3
Boiling Point798.1±60.0 °C at 760 mmHg
Melting Point261.8-263.2ºC
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 611-40-5 |
| Catalog No. | 2A-9024138 |
| Chinese Name | 射干苷 |
| Synonyms | Tectorigenin 7-glucoside; 4',5-Dihydro-6-methoxy-7-(o-glucoside)isoflavone; 5-Hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4-oxo-4H-chromen-7-yl β-D-glucopyranoside; Shekanin; tectoridin |
| Molecular Formula | C22H22O11 |
| Molecular Weight | 462.40 |
| Purity | ≥95.0 (HPLC) |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 798.1±60.0 °C at 760 mmHg |
| Melting Point | 261.8-263.2ºC |
| Appearance | powder |
| Storage Condition | 0-10°C; avoid heating |
| Application | Tectoridin is an isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen that activates estrogen and thyroid hormone receptors. Tectoridin exerts estrogenic effects through ER-depend |
| HTC | 29389090 |
| MDL Number | MFCD04039835 |
| SMILES | O[C@@H]1[C@@H](O)[C@H](OC2=CC(OC(C3=CC=C(O)C=C3)=CC4=O)=C4C(O)=C2OC)O[C@H](CO)[C@H]1O |
| InChI | 1S/C22H22O11/c1-30-21-14(32-22-20(29)19(28)17(26)15(8-23)33-22)7-13-16(18(21)27)11(25)6-12(31-13)9-2-4-10(24)5-3-9/h2-7,15,17,19-20,22-24,26-29H,8H2,1H3/t15-,17-,19+,20-,22-/m1/s1 |
| InChI Key | GCLAFEGUXXHIFT-IWLDQSELSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | transportation |
| MSDS | msds/24138_1_611_40_5.pdf |
| Bioactivity | Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway[1][2]. Related Catalog Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer In Vitro Tectoridin scarcely binds to ER alpha as compared to 17beta-estradiol and genistein[2]. Tectoridin induceds potent estrogenic effects, namely recovery of the population of cells in the S-phase after serum starvation, transactivation of the estrogen response element, and induction of MCF-7 cell proliferation[2]. Tectoridin induces estrogenic effect, and this effect is severely abrogated by treatment with U0126 ( MEK1/2 inhibitor). Tectoridin promotes phosphorylation of ERK1/2, but does not affect phosphorylation of ER alpha at Ser (118). It also increases cellular accumulation of cAMP[2]. References [1]. Shim M, et al. Tectoridin from Maackia amurensis modulates both estrogen and thyroid receptors.Phytomedicine. 2014 Apr 15;21(5):602-6. [2]. Kang K, et al. Tectoridin, a poor ligand of estrogen receptor alpha, exerts its estrogenic effects via an ERK-dependent pathway.Mol Cells. 2009 Mar 31;27(3):351-7. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 798.1±60.0 °C at 760 mmHg Melting Point 261.8-263.2ºC Molecular Formula C22H22O11 Molecular Weight 462.404 Flash Point 279.7±26.4 °C Exact Mass 462.116211 PSA 179.28000 LogP 0.29 Vapour Pressure 0.0±3.0 mmHg at 25°C Index of Refraction 1.695 |
| Use of | Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway[1][2]. Properties Articles25 Name tectoridin Synonym More Synonyms tectoridin Biological Activity Description Tectoridin is a isoflavone isolated from Maackia amurensis. Tectoridin is a phytoestrogen and activates estrogen and thyroid hormone receptors. Tectoridin exerts the estrogenic effects via ER-dependent genomic pathway and GPR30-dependent nongenomic pathway[1][2]. Related Catalog Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer References [1]. Shim M, et al. Tectoridin from Maackia amurensis modulates both estrogen and thyroid receptors.Phytomedicine. 2014 Apr 15;21(5):602-6. [2]. Kang K, et al. Tectoridin, a poor ligand of estrogen receptor alpha, exerts its estrogenic effects via an ERK-dependent pathway.Mol Cells. 2009 Mar 31;27(3):351-7. Chemical & Physical Properties Molecular Formula C22H22O11 Exact Mass 462.116211 PSA 179.28000 Index of Refraction 1.695 |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip. |
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