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Thiocolchicoside structure, CAS 602-41-5

Thiocolchicoside

CAS Number602-41-5

SynonymsThiocolchicoside; UNII:T1X8S697GT; Thiocolchicine Glycoside; R. 271; Coltramyl; Musco-ril; 3,10-Di(demethoxy)-3-glucosyloxy-10-methylthiocolchicine; 10-Thiocolchicoside; Tiocolchicoside

Molecular FormulaC27H33NO10S

Molecular Weight563.63

Purity98.00%

Density1.5±0.1 g/cm3

Boiling Point929.6±65.0 °C at 760 mmHg

Melting Point190-198ºC

Flash Point

AppearanceSolid;Light orange to Yellow to Green powder to crystal

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Cat. No.: 2A-9023984 Purity: 98.00%
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Quality Control of [ 602-41-5 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number602-41-5
Catalog No.2A-9023984
Chinese Name硫代秋水仙苷
SynonymsThiocolchicoside; UNII:T1X8S697GT; Thiocolchicine Glycoside; R. 271; Coltramyl; Musco-ril; 3,10-Di(demethoxy)-3-glucosyloxy-10-methylthiocolchicine; 10-Thiocolchicoside; Tiocolchicoside
Molecular FormulaC27H33NO10S
Molecular Weight563.63
Purity98.00
Density1.5±0.1 g/cm3
Boiling Point929.6±65.0 °C at 760 mmHg
Melting Point190-198ºC
AppearanceSolid;Light orange to Yellow to Green powder to crystal
Storage Condition0-10°C; avoid heating
ApplicationThiocolchicoside is a competitive gamma-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist in the central nervous system. Thiocolchicoside is a semisynthetic sulfur deri
MDL NumberC27H33NO10S
SMILESCOc1c(OC2OC(CO)C(O)C(O)C2O)cc2c(c1OC)-c1ccc(SC)c(=O)cc1C(NC(C)=O)CC2
InChIInChI=1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16?,19-,22-,23+,24-,27-/m1/s1
InChI KeyLEQAKWQJCITZNK-AXHKHJLKSA-N
MSDSmsds/23984_1_602_41_5.pdf
BioactivityThiocolchicoside is a competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist in the central nervous system. Thiocolchicoside is a semisynthetic sulfur derivative of colchicoside. Thiocolchicoside is a muscle relaxant and has anti-inflammatory, and analgesic properties[1]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor Target GABAA) receptor; glycine receptor[1] In Vitro Thiocolchicoside (0.001, 0.1, 1, 10, 100 μM) reduces the amplitude of eIPSCs in a concentration-dependent manner with this effect being significant at 0.1 μM and maximal at 10 μM[1]. References [1]. Carta M, et al. The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system. Neuropharmacology. 2006 Sep;51(4):805-15. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 929.6±65.0 °C at 760 mmHg Melting Point 190-198ºC Molecular Formula C27H33NO10S Molecular Weight 563.617 Flash Point 516.0±34.3 °C Exact Mass 563.182495 PSA 189.31000 LogP -1.23 Vapour Pressure 0.0±0.3 mmHg at 25°C Index of Refraction 1.657 InChIKey LEQAKWQJCITZNK-AXHKHJLKSA-N SMILES COc1c(OC2OC(CO)C(O)C(O)C2O)cc2c(c1OC)-c1ccc(SC)c(=O)cc1C(NC(C)=O)CC2
Use ofThiocolchicoside is a competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist in the central nervous system. Thiocolchicoside is a semisynthetic sulfur derivative of colchicoside. Thiocolchicoside is a muscle relaxant and has anti-inflammatory, and analgesic properties[1]. Properties Name Thiocolchicoside Synonym More Synonyms Thiocolchicoside Biological Activity Description Thiocolchicoside is a competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist in the central nervous system. Thiocolchicoside is a semisynthetic sulfur derivative of colchicoside. Thiocolchicoside is a muscle relaxant and has anti-inflammatory, and analgesic properties[1]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor GABAA) receptor; glycine receptor[1] In Vitro Thiocolchicoside (0.001, 0.1, 1, 10, 100 μM) reduces the amplitude of eIPSCs in a concentration-dependent manner with this effect being significant at 0.1 μM and maximal at 10 μM[1]. References [1]. Carta M, et al. The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system. Neuropharmacology. 2006 Sep;51(4):805-15. Chemical & Physical Properties Molecular Formula C27H33NO10S Exact Mass 563.182495 PSA 189.31000 LogP -1.23 Index of Refraction 1.657 InChIKey LEQAKWQJCITZNK-AXHKHJLKSA-N
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified
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