CAS Number552-59-0
Synonyms5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one; Prunusetin; 5,4'-dihydroxy-7-methoxyisoflavone; Prunetin; 7-methoxy-4',5-dihydroxyisoflavone; 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxychromen-4-one; 7-O-methyl-genistein; 4',5-dihydroxy-7-methoxyisoflavone; 4',5-dihydroxy-7-methoxygenistein; EINECS 209-018-5; MFCD00016951
Molecular FormulaC16H12O5
Molecular Weight284.26
Purity≥98.0 (TLC)%
Density1.4±0.1 g/cm3
Boiling Point546.5±50.0 °C at 760 mmHg
Melting Point240-242ºC
Appearancepowder
EINECS209-018-5
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 552-59-0 |
| Catalog No. | 2A-9022836 |
| Chinese Name | 樱黄素 |
| Synonyms | 5-Hydroxy-3-(4-hydroxyphenyl)-7-methoxy-4H-chromen-4-one; Prunusetin; 5,4'-dihydroxy-7-methoxyisoflavone; Prunetin; 7-methoxy-4',5-dihydroxyisoflavone; 5-hydroxy-3-(4-hydroxyphenyl)-7-methoxychromen-4-one; 7-O-methyl-genistein; 4',5-dihydroxy-7-methoxyisoflavone; 4',5-dihydroxy-7-methoxygenistein; EINECS 209-018-5; MFCD00016951 |
| Molecular Formula | C16H12O5 |
| Molecular Weight | 284.26 |
| Purity | ≥98.0 (TLC) |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 546.5±50.0 °C at 760 mmHg |
| Melting Point | 240-242ºC |
| Appearance | powder |
| Storage Condition | Room temperature, inert gas, sealed |
| Application | Prunetin is an O-methylated isoflavone with anti-inflammatory activity. Prunetin is a potent inhibitor of human aldehyde dehydrogenase. |
| EINECS | 209-018-5 |
| HTC | 2914509090 |
| PubChem ID | 57652916 |
| MDL Number | MFCD00016951 |
| SMILES | COc1cc(O)c2C(=O)C(=COc2c1)c3ccc(O)cc3 |
| InChI | 1S/C16H12O5/c1-20-11-6-13(18)15-14(7-11)21-8-12(16(15)19)9-2-4-10(17)5-3-9/h2-8,17-18H,1H3 |
| InChI Key | KQMVAGISDHMXJJ-UHFFFAOYSA-N |
| Beilstein/REAXYS | 292155 |
| NACRES Code | NA.77 |
| UNSPSC | 51111800 |
| Hazard Symbols | Transport |
| Safety Description | S22;S24/25 |
| MSDS | msds/22836_1_552_59_0.pdf |
| Bioactivity | Prunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor[1][2]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Aldehyde Dehydrogenase (ALDH) Research Areas >> Inflammation/Immunology In Vitro Prunetin inhibited LPS-induced inflammatory cytokine production and MUC5 AC expression and secretion by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells[1]. References [1]. Hu H, et al. Prunetin inhibits lipopolysaccharide-induced inflammatory cytokine production and MUC5AC expression by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells. Biomed Pharmacother. 2018 Oct;106:1469-1477. [2]. Sheikh S, et al. Allosteric inhibition of human liver aldehyde dehydrogenase by the isoflavone prunetin. Biochem Pharmacol. 1997 Feb 21;53(4):471-8. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 546.5±50.0 °C at 760 mmHg Melting Point 240-242ºC Molecular Formula C16H12O5 Molecular Weight 284.263 Flash Point 209.7±23.6 °C Exact Mass 284.068481 PSA 79.90000 LogP 3.53 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.669 |
| Use of | Prunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor[1][2]. Properties Articles17 Name prunetin Synonym More Synonyms Prunetin Biological Activity Description Prunetin, an O-methylated isoflavone, possesses anti-inflammatory activity. Prunetin is a potent human aldehyde dehydrogenases inhibitor[1][2]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Aldehyde Dehydrogenase (ALDH) Research Areas >> Inflammation/Immunology References [2]. Sheikh S, et al. Allosteric inhibition of human liver aldehyde dehydrogenase by the isoflavone prunetin. Biochem Pharmacol. 1997 Feb 21;53(4):471-8. Chemical & Physical Properties Molecular Formula C16H12O5 Exact Mass 284.068481 PSA 79.90000 Index of Refraction 1.669 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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