CAS Number552-58-9
SynonymsMFCD00135890; (S)-3',4',5,7-Tetrahydroxyflavanone; EINECS 209-016-4; T66 BO EVT&J CR CQ DQ& GQ IQ &&S Form; (2S)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydro-4H-chromen-4-one; (S)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one; Eriodictiol; (S)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4-benzopyrone; Eriodictyol
Molecular FormulaC15H12O6
Molecular Weight288.26
Purity98.00%
Density1.6±0.1 g/cm3
Boiling Point625.2±55.0 °C at 760 mmHg
Melting Point270ºC
Appearancepowder
EINECS209-016-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 552-58-9 |
| Catalog No. | 2A-9022835 |
| Chinese Name | 圣草酚 |
| Synonyms | MFCD00135890; (S)-3',4',5,7-Tetrahydroxyflavanone; EINECS 209-016-4; T66 BO EVT&J CR CQ DQ& GQ IQ &&S Form; (2S)-2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-2,3-dihydro-4H-chromen-4-one; (S)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one; Eriodictiol; (S)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4-benzopyrone; Eriodictyol |
| Molecular Formula | C15H12O6 |
| Molecular Weight | 288.26 |
| Purity | 98.00 |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 625.2±55.0 °C at 760 mmHg |
| Melting Point | 270ºC |
| Appearance | powder |
| Storage Condition | ?20°C |
| Application | Eriodictyol is a flavonoid obtained from Chinese herbal medicine and has antioxidant and anti-inflammatory effects. Eriodictyol induces the Nrf2 signaling pathway. |
| EINECS | 209-016-4 |
| HTC | 2932999099 |
| MDL Number | MFCD00135890 |
| SMILES | O=C1CC(c2ccc(O)c(O)c2)Oc2cc(O)cc(O)c21 |
| InChI | InChI=1S/C15H12O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-5,13,16-19H,6H2/t13-/m0/s1 |
| InChI Key | SBHXYTNGIZCORC-ZDUSSCGKSA-N |
| Hazard Symbols | Transport |
| Risk Codes | R36/37/38 |
| Safety Description | S26;S37/39 |
| MSDS | msds/22835_1_552_58_9.pdf |
| Bioactivity | Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol induces Nrf2 signaling pathway. Related Catalog Signaling Pathways >> NF-κB >> Keap1-Nrf2 Natural Products >> Flavonoids Research Areas >> Inflammation/Immunology Target Human Endogenous Metabolite In Vitro Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity[1]. Eriodictyol (20, 40, 80 μM) protects primary cultured cortical neurons against Aβ25-35-induced cytotoxicity and cell apoptosis via the Nrf2/ARE pathway. Eriodictyol (80 μM) induces nuclear expression of Nrf2 and the expression of ARE-regulated genes in primary cultured cortical neurons[2]. In Vivo Eriodictyol shows protective effect against LPS-induced acute lung injury (ALI). Eriodictyol (30 mg/kg, p.o.) decreases the production of inflammatory cytokines, elevates survival rate, and decreases oxidative stress levels in LPS-induced ALI mice. Eriodictyol inhibits MPO activity and inflammatory neutrophil accumulation in the lung tissues. Eriodictyol treatment also enhances Trx1 expression by upregulating the Nrf2 expression in lung tissues[1]. Cell Assay Primary cultures of cortical neurons are prepared from day 17 Sprague-Dawley rat embryos and maintained in Neurobasal A medium supplemented with B27. Experiments are performed 7 days after seeding. Aβ25-35 is dissolved in deionized distilled water at a concentration of 1 mM and incubated at 37°C for 7 days to induce its aggregation. Eriodictyol is added at indicated concentrations (20, 40, 80 μM) 2 h prior to Aβ25-35 treatment. Eriodictyol is dissolved in dimethyl sulfoxide (DMSO) at 64 mM as stock solution and diluted in culture medium before use[2]. Animal Admin Mice[1] Eighty female C57BL/6 mice are anesthetized by an intraperitoneal injection of 150 mg/kg ketamine HCl and 65 µg/kg xylazine hydrochloride. E. coli LPS is instilled intratracheally (25 µg in 50 µL sterile saline) during inspiration. The control mice receive PBS instillation, while the Eriodictyol- and vehicle-treated mice receive Eriodictyol (30 mg/kg, dissolved in PBS) and vehicle (PBS), respectively, orally 2 days prior to the induction of ALI. The mice are then sacrificed by an intravenous injection of thiopental 24 h after the induction of ALI. The thorax is opened and the blood is sampled by cardiac puncture. Simultaneously, three bronchoalveolar lavage (BAL) procedures are performed, each using 0.5 mL normal saline. The blood is centrifuged (2,000 × g, for 10 min at 4°C) and the serum is stored for further processing; the survival curve is then depicted using the Kaplan-Meier method[1]. References [1]. Zhu GF, et al. Eriodictyol, a plant flavonoid, attenuates LPS-induced acute lung injury through its antioxidative and anti-inflammatory activity. Exp Ther Med. 2015 Dec;10(6):2259-2266. Epub 2015 Oct 23. [2]. Jing X, et al. Eriodictyol Attenuates β-Amyloid 25-35 Peptide-Induced Oxidative Cell Death in Primary Cultured Neurons by Activation of Nrf2. Neurochem Res. 2015 Jul;40(7):1463-71. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 625.2±55.0 °C at 760 mmHg Melting Point 270ºC Molecular Formula C15H12O6 Molecular Weight 288.252 Flash Point 241.9±25.0 °C Exact Mass 288.063385 PSA 107.22000 LogP 2.59 Vapour Pressure 0.0±1.9 mmHg at 25°C Index of Refraction 1.725 InChIKey SBHXYTNGIZCORC-ZDUSSCGKSA-N SMILES O=C1CC(c2ccc(O)c(O)c2)Oc2cc(O)cc(O)c21 Storage condition ?20°C |
| Use of | Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol induces Nrf2 signaling pathway. Properties Articles57 Name eriodictyol Synonym More Synonyms Eriodictyol Biological Activity Description Eriodictyol is a flavonoid isolated from the Chinese herb, with antioxidant and anti-inflammatory activity. Eriodictyol induces Nrf2 signaling pathway. Related Catalog Signaling Pathways >> NF-κB >> Keap1-Nrf2 Natural Products >> Flavonoids Research Areas >> Inflammation/Immunology Human Endogenous Metabolite References [1]. Zhu GF, et al. Eriodictyol, a plant flavonoid, attenuates LPS-induced acute lung injury through its antioxidative and anti-inflammatory activity. Exp Ther Med. 2015 Dec;10(6):2259-2266. Epub 2015 Oct 23. [2]. Jing X, et al. Eriodictyol Attenuates β-Amyloid 25-35 Peptide-Induced Oxidative Cell Death in Primary Cultured Neurons by Activation of Nrf2. Neurochem Res. 2015 Jul;40(7):1463-71. Chemical & Physical Properties Molecular Formula C15H12O6 Exact Mass 288.063385 PSA 107.22000 Index of Refraction 1.725 InChIKey SBHXYTNGIZCORC-ZDUSSCGKSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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