CAS Number548-77-6
Synonyms5,7-dihydroxy-3-(4-hydroxyphenyl)-6-methoxychromen-4-one; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one; Tectorigenin
Molecular FormulaC16H12O6
Molecular Weight300.26
Purity≥95.0 (HPLC)%
Density1.512
Boiling Point601.5±55.0 °C at 760 mmHg
Melting Point225-226°
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 548-77-6 |
| Catalog No. | 2A-9022817 |
| Chinese Name | 鸢尾黄素 |
| Synonyms | 5,7-dihydroxy-3-(4-hydroxyphenyl)-6-methoxychromen-4-one; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one; 5,7-Dihydroxy-3-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one; Tectorigenin |
| Molecular Formula | C16H12O6 |
| Molecular Weight | 300.26 |
| Purity | ≥95.0 (HPLC) |
| Density | 1.512 |
| Boiling Point | 601.5±55.0 °C at 760 mmHg |
| Melting Point | 225-226° |
| Appearance | solid |
| Storage Condition | 2-8°C |
| Application | Tectorigenin is a plant isoflavone originally isolated from the dried flowers of kudzu root. |
| HTC | 2914509090 |
| MDL Number | MFCD00597094 |
| SMILES | OC(C=C1)=CC=C1C2=COC3=CC(O)=C(OC)C(O)=C3C2=O |
| InChI | 1S/C16H12O6/c1-21-16-11(18)6-12-13(15(16)20)14(19)10(7-22-12)8-2-4-9(17)5-3-8/h2-7,17-18,20H,1H3 |
| InChI Key | OBBCRPUNCUPUOS-UHFFFAOYSA-N |
| Beilstein/REAXYS | 305601 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/22817_1_548_77_6.pdf |
| Bioactivity | Tectorigenin is a plant isoflavonoid originally isolated from the dried flower of Pueraria thomsonii Benth. Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Flavonoids Research Areas >> Inflammation/Immunology In Vitro Tectorigenin is a plant isoflavonoid originally isolated from the dried flower of Pueraria thomsonii Benth. Palmitic acid (PA)-stimulated ROS production is abolished by treatment with Tectorigenin for HUVECs in a dose-dependent manner (0.1, 1, 10 μM). Treatment with Tectorigenin attenuates enhanced IKKβ phosphorylation and effectively blocks NF-κB activation by inhibition of p65 phosphorylation at concentrations ranging from 0.1 to 10 μM. Tectorigenin treatment also effectively inhibits PA-augmented TNF-α and IL-6 production in a concentration dependent manner[1]. The number of viable HepG2 cells treated by Tectorigenin decreases in a concentration- and time-dependent manner. When HepG2 cells are treated with Tectorigenin at 5, 10 and 20 mg/L for 24 h, the viability rate is 91%, 79% and 62%, respectively[2]. Kinase Assay HUVECs grown to confluence in 24-well plates are pretreated with Tectorigenin (0.1, 1, 10 μM), salicylate (5 mM) or GSH (1 mM) for 30 min, then stimulated with Palmitic acid (PA) (100 μM) for further 12 h in serum-free medium, and the medium is then collected on ice. The levels of TNF-α and IL-6 in the supernatant are assayed with commercial ELISA Kits[1]. Cell Assay Cell viability is assessed by MTT method. Briefly, cells are seeded in 96-well plate at a density of 1×104 cells/well. After 24 h incubation, Tectorigenin at different concentrations is added to the cells while only DMSO (solvent) is added as a negative control. After growing for 12, 24 and 48 h, cells are incubated with MTT (0.5 mg/mL) for 4 h at 37°C. During this incubation period, water-insoluble formazan crystals are formed, which are dissolved by the addition of 100 μL/well DMSO. The optical densities at 570 nm are measured using an enzyme-linked immunosorbent assay plate reader. Wells containing culture medium and MTT but no cells act as blanks[2]. References [1]. Wang Q, et al. Tectorigenin Attenuates Palmitate-Induced Endothelial Insulin Resistance via Targeting ROS-Associated Inflammation and IRS-1 Pathway. PLoS One. 2013 Jun 19;8(6):e66417. [2]. Jiang CP, et al. Pro-apoptotic effects of tectorigenin on human hepatocellular carcinoma HepG2 cells. World J Gastroenterol. 2012 Apr 21;18(15):1753-64. Chemical & Physical Properties Density 1.512 Boiling Point 601.5±55.0 °C at 760 mmHg Melting Point 225-226° Molecular Formula C16H12O6 Molecular Weight 300.263 Flash Point 230.1±25.0 °C Exact Mass 300.063385 PSA 100.13000 LogP 2.54 Vapour Pressure 0.0±1.8 mmHg at 25°C Index of Refraction 1.697 InChIKey OBBCRPUNCUPUOS-UHFFFAOYSA-N SMILES COc1c(O)cc2occ(-c3ccc(O)cc3)c(=O)c2c1O Storage condition 2-8°C |
| Use of | Tectorigenin is a plant isoflavonoid originally isolated from the dried flower of Pueraria thomsonii Benth. Properties Name tectorigenin Synonym More Synonyms Tectorigenin Biological Activity Description Tectorigenin is a plant isoflavonoid originally isolated from the dried flower of Pueraria thomsonii Benth. Related Catalog Signaling Pathways >> Others >> Others Natural Products >> Flavonoids Research Areas >> Inflammation/Immunology References [1]. Wang Q, et al. Tectorigenin Attenuates Palmitate-Induced Endothelial Insulin Resistance via Targeting ROS-Associated Inflammation and IRS-1 Pathway. PLoS One. 2013 Jun 19;8(6):e66417. Chemical & Physical Properties Molecular Formula C16H12O6 Exact Mass 300.063385 PSA 100.13000 Index of Refraction 1.697 InChIKey OBBCRPUNCUPUOS-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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