CAS Number539-21-9
Synonyms[1,4]Benzochinon-carbamimidoylhydrazon-thiosemicarbazon; Ambazona [inn-spanish]; Benzoqu; anginon; Faringosept; ambazon; [1,4]benzoquinone-carbamimidoylhydrazone thiosemicarbazone; promassol; primal; Benzochinon-(1,4)-monoguanylhydrazon-monothiosemicarbazon; Ambazona; Inversal
Molecular FormulaC8H11N7S1
Molecular Weight237.29
Purity98.00%
Density1.57g/cm3
Boiling Point461.9ºC at 760mmHg
Melting Point195°C (rough estimate)
Appearancesolid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 539-21-9 |
| Catalog No. | 2A-9022713 |
| Chinese Name | 安巴腙 |
| Synonyms | [1,4]Benzochinon-carbamimidoylhydrazon-thiosemicarbazon; Ambazona [inn-spanish]; Benzoqu; anginon; Faringosept; ambazon; [1,4]benzoquinone-carbamimidoylhydrazone thiosemicarbazone; promassol; primal; Benzochinon-(1,4)-monoguanylhydrazon-monothiosemicarbazon; Ambazona; Inversal |
| Molecular Formula | C8H11N7S1 |
| Molecular Weight | 237.29 |
| Purity | 98.00 |
| Density | 1.57g/cm3 |
| Boiling Point | 461.9ºC at 760mmHg |
| Melting Point | 195°C (rough estimate) |
| Appearance | solid |
| Storage Condition | Warehouse Ventilation Low Temperature Drying |
| Application | Ambazone is an orally active film-active antineoplastic agent. Ambazone also shows antibacterial and weak antiviral activity[1]. |
| HTC | 2930909090 |
| MDL Number | MFCD01038073 |
| SMILES | NC(=S)N=Nc1ccc(NN=C(N)N)cc1 |
| InChI | InChI=1S/C8H11N7S/c9-7(10)14-12-5-1-3-6(4-2-5)13-15-8(11)16/h1-4,12H,(H2,11,16)(H4,9,10,14) |
| InChI Key | ANZIOUQAFBXNHU-UHFFFAOYSA-N |
| MSDS | msds/22713_1_539_21_9.pdf |
| Use of | Ambazone is an orally active membrane active antitumor agent. Ambazone also shows antibacterial and weak antiviral activities[1]. Properties Name Ambazone Synonym More Synonyms Ambazone Biological Activity Description Ambazone is an orally active membrane active antitumor agent. Ambazone also shows antibacterial and weak antiviral activities[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Anti-infection >> Bacterial References [1]. G Löber, et al. Ambazone as a membrane active antitumor drug. Biophys Chem. 1990 Apr;35(2-3):287-300. Chemical & Physical Properties Molecular Formula C8H11N7S Exact Mass 237.08000 PSA 156.76000 LogP 1.42280 Index of Refraction 1.761 InChIKey ANZIOUQAFBXNHU-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Guanidine, ((4-oxo-2,5-cyclohexadien-1-ylidene)amino)-, thiosemicarbazone CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C8-H11-N7-S MOLECULAR WEIGHT : WISWESSER LINE NOTATION : SUYZMNU- AL6Y DYJ DUNMYZUM HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Gastrointestinal - other changes Endocrine - changes in thymus weight Blood - changes in bone marrow (not otherwise specified) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain MUTATION DATA TYPE OF TEST : DNA repair TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : REFERENCE : STBIBN Studia Biophysica. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.1- 1966- Volume(issue)/page/year: 117,99,1987 Safety Information HS Code 2930909090 Synthetic Route Total: 1 Page dihydroambazone CAS#:61566-17-4 CAS#:539-21-9 Literature: Pharmazie, , vol. 45, # 1 p. 41 - 42 Hydrazinecarbox... CAS#:7316-92-9 Thiosemicarbazide CAS#:79-19-6 CAS#:539-21-9 Literature: Angewandte Chemie, , vol. 67, p. 217,219 Precursor & DownStream Precursor 3 CAS#:61566-17-4 dihydroambazone CAS#:7316-92-9 Hydrazinecarbox... CAS#:79-19-6 Thiosemicarbazide DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2930909090. other organo-sulfur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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