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N,N'-Dimethylthiourea structure, CAS 534-13-4

N,N'-Dimethylthiourea

CAS Number534-13-4

SynonymsN,N'-DIMETHYLTHIOUREA; 1,3-dimethyl-2-thiourea; N,N'-Dimethylthiourea; 1,3-Dimethylthiourea; MFCD00004923; N,N′-dimethylthiourea; EINECS 208-588-2

Molecular FormulaCH3NHCSNHCH3

Molecular Weight104.17

Purity99%

Density1.0±0.1 g/cm3

Boiling Point121.6±23.0 °C at 760 mmHg

Melting Point61-63 °C

Flash Point

Appearancecrystals

EINECS208-588-2

MSDSChineseEnglish

Symbol6.1(b)

Signal WordWarning

Cat. No.: 2A-9022656 Purity: 99%
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Quality Control of [ 534-13-4 ] Purity: 99% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number534-13-4
Catalog No.2A-9022656
Chinese NameN,N′-二甲基硫脲
SynonymsN,N'-DIMETHYLTHIOUREA; 1,3-dimethyl-2-thiourea; N,N'-Dimethylthiourea; 1,3-Dimethylthiourea; MFCD00004923; N,N′-dimethylthiourea; EINECS 208-588-2
Molecular FormulaCH3NHCSNHCH3
Molecular Weight104.17
Purity99
Density1.0±0.1 g/cm3
Boiling Point121.6±23.0 °C at 760 mmHg
Melting Point61-63 °C
Appearancecrystals
Storage ConditionStore in a cool, dry, well-ventilated warehouse. K
PackagingIII
ApplicationN,N'-Dimethylthiourea (DMTU), isolated from black garlic, is an orally effective scavenger of hydroxyl free radicals (•OH), preventing the production of •OH in vitro by activated neutrophils. N,N'-Dim
EINECS208-588-2
HTC2930909090
PubChem ID24893565
MDL NumberMFCD00004923
SMILESCNC(=S)NC
InChI1S/C3H8N2S/c1-4-3(6)5-2/h1-2H3,(H2,4,5,6)
InChI KeyVLCDUOXHFNUCKK-UHFFFAOYSA-N
Beilstein/REAXYS605454
NACRES CodeNA.22
UNSPSC12352100
Hazard Symbols6.1(b)
MSDSmsds/22656_1_534_13_4.pdf
BioactivityN,N'-Dimethylthiourea (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical (•OH) and blocks •OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including •OH scavenging and anti-inflammatory action[1][2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology In Vivo N,N'-Dimethylthiourea (DMTU; 1, 2.5, or 5 mmol/kg; orally) administered at 0.5 h before the onset of WIRS reduces the severity of gastric mucosal lesions with attenuation of the changes in the levels of gastric mucosal MPO, pro-inflammatory cytokines, LPO, NOx, nonprotein SH, and vitamin C and gastric adherent mucus found at 3 h after the onset of WIRS in a dose-dependent manner in Male Wistar rats aged 6 weeks[1]. References [1]. Yoshiji Ohta, et al. Protective effect of N,N'-dimethylthiourea against stress-induced gastric mucosal lesions in rats. Fundam Clin Pharmacol. 2017 Jun;31(3):319-328. [2]. Zhongyi Zhang, et al. Analysis of volatile compounds in fermented black garlic by GC-MS. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 121.6±23.0 °C at 760 mmHg Melting Point 61-63 °C Molecular Formula C3H8N2S Molecular Weight 104.174 Flash Point 27.3±22.6 °C Exact Mass 104.040817 PSA 56.15000 LogP -0.35 Vapour Pressure 14.5±0.2 mmHg at 25°C Index of Refraction 1.516 InChIKey VLCDUOXHFNUCKK-UHFFFAOYSA-N SMILES CNC(=S)NC
Use ofN,N'-Dimethylthiourea (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical (•OH) and blocks •OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including •OH scavenging and anti-inflammatory action[1][2]. Properties Name N,N′-Dimethylthiourea Synonym More Synonyms N,N'-Dimethylthiourea Biological Activity Description N,N'-Dimethylthiourea (DMTU), isolated from Allii Sativi Bulbus, is an orally active scavenger of hydroxyl radical (•OH) and blocks •OH production by activated neutrophils in vitro. N,N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS)-induced gastric mucosal lesions in rats by exerting its antioxidant action including •OH scavenging and anti-inflammatory action[1][2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology References [1]. Yoshiji Ohta, et al. Protective effect of N,N'-dimethylthiourea against stress-induced gastric mucosal lesions in rats. Fundam Clin Pharmacol. 2017 Jun;31(3):319-328. [2]. Zhongyi Zhang, et al. Analysis of volatile compounds in fermented black garlic by GC-MS. Chemical & Physical Properties Molecular Formula C3H8N2S Exact Mass 104.040817 PSA 56.15000 LogP -0.35 Index of Refraction 1.516 InChIKey VLCDUOXHFNUCKK-UHFFFAOYSA-N SMILES CNC(=S)NC
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 30.0%
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (1,3-Dimethyl-2-thiourea) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (1,3-Dimethyl-2-thiourea) International Air Transport Risk Regulations: Toxic solid, organic, n.o.s. (1,3-Dimethyl-2-thiourea) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip.
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