CAS Number122898-67-3
SynonymsMFCD00867431; UNII-81BMQ80QRL; N-<4-<2-(dimethylamino)ethoxy>benzyl>-3,4-dimethoxybenzamide; Ganaton; N-{4-[2-(Dimethylamino)ethoxy]benzyl}-3,4-dimethoxybenzamide
Molecular FormulaC20H26N2O4
Molecular Weight394.89
Purity≥98 (HPLC)%
Density1.1±0.1 g/cm3
Boiling Point510.1±50.0 °C at 760 mmHg
Melting Point185-187 °C(lit.)
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 122898-67-3 |
| Catalog No. | 2A-9022628 |
| Chinese Name | 伊托必利 |
| Synonyms | MFCD00867431; UNII-81BMQ80QRL; N-<4-<2-(dimethylamino)ethoxy>benzyl>-3,4-dimethoxybenzamide; Ganaton; N-{4-[2-(Dimethylamino)ethoxy]benzyl}-3,4-dimethoxybenzamide |
| Molecular Formula | C20H26N2O4 |
| Molecular Weight | 394.89 |
| Purity | ≥98 (HPLC) |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 510.1±50.0 °C at 760 mmHg |
| Melting Point | 185-187 °C(lit.) |
| Appearance | powder |
| Water Solubility | 18 g/100 mL (20 ºC) |
| Application | Itopride (HSR803 free base) is an orally available dopamine-2 antagonist and acetylcholinesterase (AChE) inhibitor. Itopride enhances gastric motility through its anti-dopamine and anti-acetylcholines |
| HTC | 2924299090 |
| PubChem ID | 329825103 |
| MDL Number | MFCD00881710 |
| SMILES | Cl.COc1ccc(cc1OC)C(=O)NCc2ccc(OCCN(C)C)cc2 |
| InChI | 1S/C20H26N2O4.ClH/c1-22(2)11-12-26-17-8-5-15(6-9-17)14-21-20(23)16-7-10-18(24-3)19(13-16)25-4;/h5-10,13H,11-12,14H2,1-4H3,(H,21,23);1H |
| InChI Key | ZTOUXLLIPWWHSR-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/22628_1_122898_67_3.pdf |
| Use of | Itopride (HSR803 free base) is a potent and orally active dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD)[1]. Properties Name N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxybenzamide Synonym More Synonyms Itopride Biological Activity Description Itopride (HSR803 free base) is a potent and orally active dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD)[1]. Related Catalog Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> AChE D2 Receptor Acetylcholinesterase In Vitro Itopride has prokinetic effects on both the ileum and colon, which are regulated through inhibitory effects on AChE and antagonistic effects on dopamine D2 receptor[3]. Itopride hydrochloride (0.1 nM-1 μM) significantly accelerats the propagation velocity of the peristalsis in ex guinea pig ileum[3]. References [1]. Iwanaga Y, et al. A novel water-soluble dopamine-2 antagonist with anticholinesterase activity in gastrointestinal motor activity. Comparison with domperidone and neostigmine. Gastroenterology. 1990 Aug;99(2):401-8. [2]. Kim YS, et al. Effect of itopride, a new prokinetic, in patients with mild GERD: a pilot study. World J Gastroenterol. 2005 Jul 21;11(27):4210-4. [3]. Hyun Chul Lim, et al. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Yonsei Med J. 2008 Jun 30;49(3):472-8. Chemical & Physical Properties Molecular Formula C20H26N2O4 Exact Mass 358.189270 PSA 60.03000 Index of Refraction 1.552 InChIKey QQQIECGTIMUVDS-UHFFFAOYSA-N Safety Information Hazard Codes T,Xi,Xn Safety Phrases S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36:Wear suitable protective clothing . HS Code 2924299090 Synthetic Route Benzamide, N-[(... CAS#:943518-63-6 2-Chloroethyldi... CAS#:107-99-3 CAS#:122898-67-3 N-(4-(2-(dimeth... CAS#:1228693-36-4 CAS#:122898-67-3 Literature: Nielsen, Simon D.; Smith, Garrick; Begtrup, Mikael; Kristensen, Jesper L. Chemistry - A European Journal, 2010 , vol. 16, # 15 p. 4557 - 4566 carbon monoxide CAS#:201230-82-2 4-[2-(dimethyla... CAS#:20059-73-8 4-Iodo-1,2-dime... CAS#:5460-32-2 CAS#:122898-67-3 Literature: Hermange, Philippe; Lindhardt, Anders T.; Taaning, Rolf H.; Bjerglund, Klaus; Lupp, Daniel; Skrydstrup, Troels Journal of the American Chemical Society, 2011 , vol. 133, # 15 p. 6061 - 6071 Precursor & DownStream Precursor 8 CAS#:943518-63-6 Benzamide, N-[(... CAS#:107-99-3 2-Chloroethyldi... CAS#:1228693-36-4 N-(4-(2-(dimeth... CAS#:201230-82-2 carbon monoxide DownStream 1 CAS#:122892-31-3 Itopride hydroc... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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