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Nipecotic acid structure, CAS 498-95-3

Nipecotic acid

CAS Number498-95-3

Synonymshexahydronicotinic acid; MFCD00005992; (±)-Nipecotic acid; (±)-Piperidine-3-carboxylic acid; Nipecotic acid; UNII:1U1QTN40SY; Piperidine-3-carboxylic acid; EINECS 207-873-9; (±)-3-Piperidine carboxylic acid; 3-Piperidinecarboxylic acid; H-DL-Nip-OH

Molecular FormulaC6H11NO2

Molecular Weight129.16

Purity97%

Density1.1±0.1 g/cm3

Boiling Point265.8±33.0 °C at 760 mmHg

Melting Point251-255 °C

Flash Point

Appearancesolid

EINECS

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9022294 Purity: 97%
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Quality Control of [ 498-95-3 ] Purity: 97% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number498-95-3
Catalog No.2A-9022294
Chinese Name3-哌啶甲酸
Synonymshexahydronicotinic acid; MFCD00005992; (±)-Nipecotic acid; (±)-Piperidine-3-carboxylic acid; Nipecotic acid; UNII:1U1QTN40SY; Piperidine-3-carboxylic acid; EINECS 207-873-9; (±)-3-Piperidine carboxylic acid; 3-Piperidinecarboxylic acid; H-DL-Nip-OH
Molecular FormulaC6H11NO2
Molecular Weight129.16
Purity97
Density1.1±0.1 g/cm3
Boiling Point265.8±33.0 °C at 760 mmHg
Melting Point251-255 °C
Appearancesolid
Storage ConditionStore sealed at 0-6°C in a ventilated, dry environ
ApplicationNicotinic acid (±-β-homoproline) is a potent inhibitor of aminobutyric acid (GABA) uptake in neurons and glia in vitro. Nicotine can also directly activate GABAA-like chloride channels, with an EC50 o
HTC2933399090
PubChem ID24884153
MDL NumberMFCD01630787
SMILESOC(=O)[C@@H]1CCCNC1
InChI1S/C6H11NO2/c8-6(9)5-2-1-3-7-4-5/h5,7H,1-4H2,(H,8,9)/t5-/m1/s1
InChI KeyXJLSEXAGTJCILF-RXMQYKEDSA-N
NACRES CodeNA.22
UNSPSC12352005
Hazard SymbolsTransport
MSDSmsds/22294_1_498_95_3.pdf
BioactivityNipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300 μM[1][2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor Target GABA Receptor[1] In Vitro Nipecotic acid (1 mM) activated inward unitary currents when applied to outside-out patches of paraventricular neurones[1]. In Vivo Nipecotic acid does not readily cross the blood-brain barrier (BBB)[2]. References [1]. Barrett-Jolley R, et, al. Nipecotic acid directly activates GABA(A)-like ion channels. Br J Pharmacol. 2001 Jul;133(5):673-8. [2]. Dhanawat M, et, al. Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug. Drug Res (Stuttg). 2021 Feb;71(2):94-103. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 265.8±33.0 °C at 760 mmHg Melting Point 261ºC (dec.) Molecular Formula C6H11NO2 Molecular Weight 129.157 Flash Point 114.5±25.4 °C Exact Mass 129.078979 PSA 49.33000 LogP -0.04 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.479 Storage condition Store at 0-5°C
Use ofNipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300 μM[1][2]. Properties Articles38 Name nipecotic acid Synonym More Synonyms Nipecotic acid Biological Activity Description Nipecotic acid ((±)-β-Homoproline) is a potent inhibitor of neuronal and glial-aminobutyric acid (GABA) uptake in vitro. Nipecotic acid can also directly activate GABAA-like chloride channels, with an EC50 of approximately 300 μM[1][2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor GABA Receptor[1] In Vivo Nipecotic acid does not readily cross the blood-brain barrier (BBB)[2]. References [1]. Barrett-Jolley R, et, al. Nipecotic acid directly activates GABA(A)-like ion channels. Br J Pharmacol. 2001 Jul;133(5):673-8. [2]. Dhanawat M, et, al. Design, Synthesis and Enhanced BBB Penetration Studies of L-serine-Tethered Nipecotic Acid-Prodrug. Drug Res (Stuttg). 2021 Feb;71(2):94-103. Chemical & Physical Properties Molecular Formula C6H11NO2 Exact Mass 129.078979 PSA 49.33000 LogP -0.04 Index of Refraction 1.479
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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