CAS Number382-67-2
Synonymsdesoximetasonum [INN_la]; Desoximetasone; EINECS 206-845-3; 9-Fluoro-11-β,21-dihydroxy-16-α-methylpregna-1,4-diene-3,20-dione; MFCD00083301; desoximetasona [INN_es]; (11β,16α)-9-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione; desoximetasone [INN_en]; Desoxymetasone
Molecular FormulaC22H29FO4
Molecular Weight362.44
Purity98.00%
Density1.3±0.1 g/cm3
Boiling Point532.3±50.0 °C at 760 mmHg
Melting Point217ºC
AppearanceWhite
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 382-67-2 |
| Catalog No. | 2A-9021615 |
| Chinese Name | 去羟米松 |
| Synonyms | desoximetasonum [INN_la]; Desoximetasone; EINECS 206-845-3; 9-Fluoro-11-β,21-dihydroxy-16-α-methylpregna-1,4-diene-3,20-dione; MFCD00083301; desoximetasona [INN_es]; (11β,16α)-9-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione; desoximetasone [INN_en]; Desoxymetasone |
| Molecular Formula | C22H29FO4 |
| Molecular Weight | 362.44 |
| Purity | 98.00 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 532.3±50.0 °C at 760 mmHg |
| Melting Point | 217ºC |
| Appearance | White |
| Storage Condition | Refrigerator |
| Application | Desoximetasone (Topicort) is a corticosteroid that can be used to relieve rashes and other skin conditions. |
| HTC | 2914700090 |
| MDL Number | MFCD00189451 |
| SMILES | C[C@@H]1CC2C3CCC4=CC(=O)C=CC4(C)[C@@]3(F)C(O)CC2(C)C1C(=O)CO |
| InChI | InChI=1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15?,16?,18?,19?,20?,21?,22+/m1/s1 |
| InChI Key | InChIKey=VWVSBHGCDBMOOT-OKPPOTDYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 12352200 |
| MSDS | msds/21615_1_382_67_2.pdf |
| Use of | Desoximetasone(Topicort) is a medication belonging to the family of medications known as topical corticosteroids; is used for the relief of various skin conditions, including rashes.IC50 value:Target: When using desoximetasone, some of the medication may be absorbed through the skin and into the bloodstream. Too much absorption can lead to unwanted side effects elsewhere in the body. To keep this problem to a minimum, avoid using large amounts of desoximetasone over large areas, do not use it for extended periods of time, and do not cover it with airtight dressings such as plastic wrap or adhesive bandages unless specifically told to by your doctor.[1] Children may absorb more medication than adults do. Desoximetasone is for use only on the skin and should be kept out of the eyes. Properties Articles26 Name desoximetasone Synonym More Synonyms Desoximetasone Biological Activity Description Desoximetasone(Topicort) is a medication belonging to the family of medications known as topical corticosteroids; is used for the relief of various skin conditions, including rashes.IC50 value:Target: When using desoximetasone, some of the medication may be absorbed through the skin and into the bloodstream. Too much absorption can lead to unwanted side effects elsewhere in the body. To keep this problem to a minimum, avoid using large amounts of desoximetasone over large areas, do not use it for extended periods of time, and do not cover it with airtight dressings such as plastic wrap or adhesive bandages unless specifically told to by your doctor.[1] Children may absorb more medication than adults do. Desoximetasone is for use only on the skin and should be kept out of the eyes. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology References [1]. Desoximetasone, From Wikipedia Chemical & Physical Properties Molecular Formula C22H29FO4 Exact Mass 376.204987 PSA 74.60000 Index of Refraction 1.574 Storage condition Refrigerator Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,21-dihydroxy-16-alpha-methyl- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C22-H29-F-O4 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : L E5 B666 OV AHTTT&J A1 BF CQ E1 FV1Q G1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SEX/DURATION : female 8-16 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 71,367,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SEX/DURATION : female 8-16 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 71,367,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous 4800 ug/kg SEX/DURATION : female 7-15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 71,367,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous 3600 ug/kg SEX/DURATION : female 7-15 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 71,367,1975 Safety Information GHS07, GHS08 Signal Word Warning Hazard Statements H302-H312-H315-H317-H319-H332-H335-H351 Precautionary Statements P261-P280-P305 + P351 + P338 Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges Hazard Codes Xn:Harmful; Safety Phrases S22-S26-S36 RIDADR NONH for all modes of transport WGK Germany 3 RTECS TU3834000 HS Code 2914700090 Synthetic Route Total: 1 Page Dexamethasone CAS#:50-02-2 Desoximetasone CAS#:382-67-2 Precursor & DownStream Precursor 1 CAS#:50-02-2 Dexamethasone DownStream 1 CAS#:75262-69-0 (8S,9R,10S,11S,... |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0% |
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