CAS Number370-81-0
SynonymsDicyclohexanoneoxaly dihydrazone; MFCD00001659; Bis(cyclohexanone) Oxalyldihydrazone; oxalic bis(cyclohexylidenehydrazide); N,N'-bis(cyclohexylideneamino)oxamide; Oxalic acid bis(cyclohexylidenehydrazide); Ethanedioic acid, bis(2-cyclohexylidenehydrazide); Cuprizon,Cuprizone,Oxalic acid bis(cyclohexylidenehydrazide); N',N'-Dicyclohexylideneethanedihydrazide; Bis(cyclohexanone)oxalyldihydrazone; Cupferazone; Oxalic Acid Bis-(Cyclohexylidenehydrazide); EINECS 206-729-2
Molecular FormulaC14H22N4O2
Molecular Weight278.35
Purity≥95 (TLC)%
Density1.3±0.1 g/cm3
Melting Point210-214 °C (lit.)
Appearancepowder
EINECS206-729-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 370-81-0 |
| Catalog No. | 2A-9021564 |
| Chinese Name | 双环己酮草酰二腙 |
| Synonyms | Dicyclohexanoneoxaly dihydrazone; MFCD00001659; Bis(cyclohexanone) Oxalyldihydrazone; oxalic bis(cyclohexylidenehydrazide); N,N'-bis(cyclohexylideneamino)oxamide; Oxalic acid bis(cyclohexylidenehydrazide); Ethanedioic acid, bis(2-cyclohexylidenehydrazide); Cuprizon,Cuprizone,Oxalic acid bis(cyclohexylidenehydrazide); N',N'-Dicyclohexylideneethanedihydrazide; Bis(cyclohexanone)oxalyldihydrazone; Cupferazone; Oxalic Acid Bis-(Cyclohexylidenehydrazide); EINECS 206-729-2 |
| Molecular Formula | C14H22N4O2 |
| Molecular Weight | 278.35 |
| Purity | ≥95 (TLC) |
| Density | 1.3±0.1 g/cm3 |
| Melting Point | 210-214 °C (lit.) |
| Appearance | powder |
| Storage Condition | Store at 2~8℃. |
| Packaging | I; II; III |
| Application | Copper reagent is a chelating agent used as a copper analysis reagent. Cuprazine is often used to study factors affecting oligodendrocyte death and myelin loss [1][2]. |
| EINECS | 206-729-2 |
| HTC | 29280090 |
| PubChem ID | 24893128 |
| MDL Number | MFCD00001659 |
| SMILES | O=C(N\N=C1\CCCCC1)C(=O)N\N=C2/CCCCC2 |
| InChI | 1S/C14H22N4O2/c19-13(17-15-11-7-3-1-4-8-11)14(20)18-16-12-9-5-2-6-10-12/h1-10H2,(H,17,19)(H,18,20) |
| InChI Key | DSRJIHMZAQEUJV-UHFFFAOYSA-N |
| Beilstein/REAXYS | 2388004 |
| NACRES Code | NA.47 |
| UNSPSC | 12171500 |
| Hazard Symbols | 6.1 |
| MSDS | msds/21564_1_370_81_0.pdf |
| Bioactivity | Cuprizone is a chelator used as a reagent for copper analysis. Cuprizone is frequently used for studying factors that affect oligodendrocytes death and myelin loss[1][2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease In Vivo Cuprizone (0.5 mg/100 mg of diet and water given ad lib; p.o.) produces severe status spongious in the CNS, most prominently in the brain stem and cerebellar white matter of mice[1]. References [1]. Suzuki K, et al. Status spongiosus of CNS and hepatic changes induced by cuprizone (biscyclohexanone oxalyldihydrazone). Am J Pathol. 1969 Feb;54(2):307-25. [2]. Sanadgol N, et al. Alpha-lipoic acid mitigates toxic-induced demyelination in the corpus callosum by lessening of oxidative stress and stimulation of polydendrocytes proliferation. Metab Brain Dis. 2018 Feb;33(1):27-37. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Melting Point 210-214 °C(lit.) Molecular Formula C14H22N4O2 Molecular Weight 278.350 Exact Mass 278.174286 PSA 82.92000 LogP 0.85 Index of Refraction 1.626 InChIKey DSRJIHMZAQEUJV-UHFFFAOYSA-N SMILES O=C(NN=C1CCCCC1)C(=O)NN=C1CCCCC1 Storage condition 2-8°C |
| Use of | Cuprizone is a chelator used as a reagent for copper analysis. Cuprizone is frequently used for studying factors that affect oligodendrocytes death and myelin loss[1][2]. Properties Articles43 Name Bis(cyclohexanone)oxaldihydrazone Synonym More Synonyms oxalic bis(cyclohexylidenehydrazide) Biological Activity Description Cuprizone is a chelator used as a reagent for copper analysis. Cuprizone is frequently used for studying factors that affect oligodendrocytes death and myelin loss[1][2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. Suzuki K, et al. Status spongiosus of CNS and hepatic changes induced by cuprizone (biscyclohexanone oxalyldihydrazone). Am J Pathol. 1969 Feb;54(2):307-25. [2]. Sanadgol N, et al. Alpha-lipoic acid mitigates toxic-induced demyelination in the corpus callosum by lessening of oxidative stress and stimulation of polydendrocytes proliferation. Metab Brain Dis. 2018 Feb;33(1):27-37. Chemical & Physical Properties Molecular Formula C14H22N4O2 Exact Mass 278.174286 PSA 82.92000 Index of Refraction 1.626 InChIKey DSRJIHMZAQEUJV-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
| Related Products in Functional Building Blocks | ||
|---|---|---|
| 3,5-Bis(trifluoromethyl)phenol | 349-58-6 | 2A-9021427 |
| 2-Methoxy-5-(trifluoromethyl)aniline | 349-65-5 | 2A-9021428 |
| 2-(Trifluoromethyl)benzamide | 360-64-5 | 2A-9021493 |
| 4,4'-Dinitro-3,3'-bis(trifluoromethyl)biphenyl | 363-95-1 | 2A-9021512 |
| 4-(Trifluoromethyl)phenylhydrazine | 368-90-1 | 2A-9021554 |
| 4-(Trifluoromethylthio)aniline | 372-16-7 | 2A-9021574 |
| 1,1,3,3,3-Pentafluoro-2-trifluoromethylpropyl methyl ether | 382-26-3 | 2A-9021612 |
| Desoximetasone | 382-67-2 | 2A-9021615 |
| 2-Bromo-4'-(trifluoromethyl)acetophenon | 383-53-9 | 2A-9021619 |
| 2-Chloro-6-fluorobenzaldehyde | 387-45-1 | 2A-9021630 |
| Browse all Functional Building Blocks products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS