CAS Number329-98-6
Synonymsα-Toluenesulfonyl fluoride; Benzenemethanesulfonyl fluoride; Phenylmethanesulfonyl fluoride (PMSF); Phenylmethylsulfonyl fluoride; Phenylmethanesulfonyl fluoride; Phenylmethanesulphonyl fluoride; Fluoride, Phenylmethanesulfonyl; phenyl methane sulfonyl fluoride; phenylmethyl-sulfonyl fluoride; PMSF; EINECS 206-350-2; Benzylsulfonyl Fluoride; Benzylsulphonyl fluoride; MFCD00007421
Molecular FormulaC7H7FO2S
Molecular Weight174.19
Purity≥98.5 (GC)%
Density1.3±0.1 g/cm3
Boiling Point285.7±19.0 °C at 760 mmHg
Melting Point91-94 °C
Appearancepowder
EINECS206-350-2
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 329-98-6 |
| Catalog No. | 2A-9021324 |
| Chinese Name | 苄磺酰氟 |
| Synonyms | α-Toluenesulfonyl fluoride; Benzenemethanesulfonyl fluoride; Phenylmethanesulfonyl fluoride (PMSF); Phenylmethylsulfonyl fluoride; Phenylmethanesulfonyl fluoride; Phenylmethanesulphonyl fluoride; Fluoride, Phenylmethanesulfonyl; phenyl methane sulfonyl fluoride; phenylmethyl-sulfonyl fluoride; PMSF; EINECS 206-350-2; Benzylsulfonyl Fluoride; Benzylsulphonyl fluoride; MFCD00007421 |
| Molecular Formula | C7H7FO2S |
| Molecular Weight | 174.19 |
| Purity | ≥98.5 (GC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 285.7±19.0 °C at 760 mmHg |
| Melting Point | 91-94 °C |
| Appearance | powder |
| Water Solubility | hydrolysis |
| Storage Condition | Store at room temperature. |
| Packaging | III |
| Application | PMSF is an irreversible serine/cysteine protease inhibitor commonly used to prepare cell lysates. |
| EINECS | 206-350-2 |
| HTC | 2904909090 |
| PubChem ID | 24898863 |
| MDL Number | MFCD00007424 |
| SMILES | FS(=O)(=O)Cc1ccccc1 |
| InChI | 1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2 |
| InChI Key | YBYRMVIVWMBXKQ-UHFFFAOYSA-N |
| Beilstein/REAXYS | 2088311 |
| NACRES Code | NA.77 |
| UNSPSC | 12352202 |
| Hazard Symbols | 8 |
| MSDS | msds/21324_1_329_98_6.pdf |
| Bioactivity | PMSF is an irreversible serine/cysteine protease inhibitor commonly used in the preparation of cell lysates. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin Research Areas >> Others In Vitro PMSF (2 mM) inhibits carbachol-stimulated inositol phosphate accumulation in the presence of Li+ by only 15%-19%. PMSF inhibition of phosphoinositide turnover is due to one or more steps following phosphoinositide breakdown[1]. PMSF inhibits the acylation of the inositol residue of GPI intermediates in bloodstream form T. brucei. PMSF inhihits the formntion of glycolipid C but does not inhibit fatty acid remodeling in vitro. PMSF inhihits GPI acylation and ethanolamine phosphatp addition in procyclic trypanosomes but not in Hela cells[2]. In Vivo PMSF (0.1 mL/10 g b.wt, i.p.) produces antinociception as indicated by the dose-responsive increase in % MPE in the tail-flick latency evaluation, but fails to produce a clear dose-responsive inhibition of locomotion. Mice receiving i.p. injections of PMSF exhibit cannabinoid effects that includes antinociception, hypothermia and immobility with ED50 values of 86, 224 and 206 mg/kg, respectively. PMSF (30 mg/kg) pretreatment potentiates the effects of anandamide on tail-flick response (antinociception), spontaneous activity and mobility by 5-, 10- and 8-fold, respectively[3]. Animal Admin Male ICR mice weighing 18 to 25 g are used in the assay. PMSF is dissolved in sesame oil and administered i.p. at a volume of 0.1 mL/10 g b.wt. PMSF is always administered 10 min before i.v. anandamide or vehicle injections. Mice are acclimated to the evaluation room overnight without interruption of food or water. After i.v. anandamide or vehicle administration each animal is evaluated as follows: tail-flick latency (antinociception) response at 5 min and spontaneous (locomotor) activity at 5 to 15 min; or core (rectal) temperature at 5 min and ring-immobility (catalepsy) at 5 to 10 min. References [1]. Sekar, M.C. and B.D. Roufogalis, Differential effects of phenylmethanesulfonyl fluoride (PMSF) on carbachol and potassium stimulated phosphoinositide turnover and contraction in longitudinal smooth muscle of guinea pig ileum. Cell Calcium, 1984. 5(3): p. [2]. Guther, M.L., W.J. Masterson, and M.A. Ferguson, The effects of phenylmethylsulfonyl fluoride on inositol-acylation and fatty acid remodeling in African trypanosomes. J Biol Chem, 1994. 269(28): p. 18694-701. [3]. Compton, D.R. and B.R. Martin, The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the pharmacological effect of anandamide in the mouse model of cannabimimetic activity. J Pharmacol Exp Ther, 1997. 283(3): p. 1138-43. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 285.7±19.0 °C at 760 mmHg Melting Point 92-95 °C Molecular Formula C7H7FO2S Molecular Weight 174.193 Flash Point 126.6±21.5 °C Exact Mass 174.015076 PSA 42.52000 LogP 2.33 Vapour Pressure 0.0±0.6 mmHg at 25°C Index of Refraction 1.522 InChIKey YBYRMVIVWMBXKQ-UHFFFAOYSA-N SMILES O=S(=O)(F)Cc1ccccc1 Storage condition 2-8°C Water Solubility hydrolysis |
| Use of | PMSF is an irreversible serine/cysteine protease inhibitor commonly used in the preparation of cell lysates. Properties Articles2640 Name phenylmethanesulfonyl fluoride Synonym More Synonyms PMSF Biological Activity Description PMSF is an irreversible serine/cysteine protease inhibitor commonly used in the preparation of cell lysates. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Cathepsin Research Areas >> Others References [1]. Sekar, M.C. and B.D. Roufogalis, Differential effects of phenylmethanesulfonyl fluoride (PMSF) on carbachol and potassium stimulated phosphoinositide turnover and contraction in longitudinal smooth muscle of guinea pig ileum. Cell Calcium, 1984. 5(3): p. [2]. Guther, M.L., W.J. Masterson, and M.A. Ferguson, The effects of phenylmethylsulfonyl fluoride on inositol-acylation and fatty acid remodeling in African trypanosomes. J Biol Chem, 1994. 269(28): p. 18694-701. [3]. Compton, D.R. and B.R. Martin, The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the pharmacological effect of anandamide in the mouse model of cannabimimetic activity. J Pharmacol Exp Ther, 1997. 283(3): p. 1138-43. Chemical & Physical Properties Molecular Formula C7H7FO2S Exact Mass 174.015076 PSA 42.52000 Index of Refraction 1.522 InChIKey YBYRMVIVWMBXKQ-UHFFFAOYSA-N Water Solubility hydrolysis |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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