CAS Number327-57-1
SynonymsL-2-Aminohexanoic acid; EINECS 206-321-4; (S)-Norleucine; Norleucine; (S)-2-amino-Hexanoic acid; (S)-(+)-2-Aminohexanoic acid; H-L-NLE-OH; Glycoleucine; H-L-NORLEUCINE; L-Norleucine; (S)-(+)-2-Aminohexanoic acid (S)-2-Aminocaproic acid; (S)-Aminohexanoic acid; (S)-a-Aminocaproic acid; L-2-Amino-hexanoic acid; L-Aminohexanoic acid; (S)-2-Aminohexanoic acid; caprine; H-NLE-OH; H-ACPO(2)-OH; L-2-aminohexanoate; H-AHX(2)-OH; D,L-Norleucine; MFCD00064423; L(+)-Norleucine; (S)-2-aminocaproic acid; N-NORLEUCINE
Molecular FormulaCH3(CH2)3CH(NH2)CO2H
Molecular Weight131.17
Purity≥98 (TLC)%
Density1.0±0.1 g/cm3
Boiling Point234.0±23.0 °C at 760 mmHg
Melting Point>300 °C (lit.)
Appearancepowder
EINECS206-321-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 327-57-1 |
| Catalog No. | 2A-9021291 |
| Chinese Name | L-正亮氨酸 |
| Synonyms | L-2-Aminohexanoic acid; EINECS 206-321-4; (S)-Norleucine; Norleucine; (S)-2-amino-Hexanoic acid; (S)-(+)-2-Aminohexanoic acid; H-L-NLE-OH; Glycoleucine; H-L-NORLEUCINE; L-Norleucine; (S)-(+)-2-Aminohexanoic acid (S)-2-Aminocaproic acid; (S)-Aminohexanoic acid; (S)-a-Aminocaproic acid; L-2-Amino-hexanoic acid; L-Aminohexanoic acid; (S)-2-Aminohexanoic acid; caprine; H-NLE-OH; H-ACPO(2)-OH; L-2-aminohexanoate; H-AHX(2)-OH; D,L-Norleucine; MFCD00064423; L(+)-Norleucine; (S)-2-aminocaproic acid; N-NORLEUCINE |
| Molecular Formula | CH3(CH2)3CH(NH2)CO2H |
| Molecular Weight | 131.17 |
| Purity | ≥98 (TLC) |
| Density | 1.0±0.1 g/cm3 |
| Boiling Point | 234.0±23.0 °C at 760 mmHg |
| Melting Point | >300 °C (lit.) |
| Appearance | powder |
| Storage Condition | Warehouse Ventilation Low Temperature Drying |
| Application | L-Norleucine is an isomer of leucine and can affect protein synthesis in skeletal muscle. |
| EINECS | 206-321-4 |
| HTC | 29224995 |
| PubChem ID | 24897796 |
| MDL Number | MFCD00064423 |
| SMILES | CCCC[C@H](N)C(O)=O |
| InChI | 1S/C6H13NO2/c1-2-3-4-5(7)6(8)9/h5H,2-4,7H2,1H3,(H,8,9)/t5-/m0/s1 |
| InChI Key | LRQKBLKVPFOOQJ-YFKPBYRVSA-N |
| Beilstein/REAXYS | 1721750 |
| NACRES Code | NA.26 |
| eCl@ss | 32160406 |
| UNSPSC | 12352209 |
| Hazard Symbols | Transport |
| MSDS | msds/21291_1_327_57_1.pdf |
| Bioactivity | L-Norleucine is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity. Related Catalog Research Areas >> Infection Natural Products >> Others Target Human Endogenous Metabolite In Vitro L-Norleucine is an isomer of leucine, specifically affecting protein synthesis in skeletal muscle[1]. L-Norleucine has antiviral activity. L-Norleucine interacts with hnRNPA2/B1 protein to suppresses the expressions of Twist1 and Snail, two inhibitors of E-cadherin, and promotes the expression of E-cadherin, resulting in the inhibition of tumor metastasis[2]. References [1]. Schott KJ, et al. On the role of branched-chain amino acids in protein turnover of skeletal muscle. Studies in vivo with L-norleucine. Z Naturforsch C. 1985 May-Jun;40(5-6):427-37. [2]. He T, et al. The homeostasis-maintaining metabolites from bacterial stress response to bacteriophage infection suppress tumor metastasis. Oncogene. 2018 Jun 20. Chemical & Physical Properties Density 1.0±0.1 g/cm3 Boiling Point 234.0±23.0 °C at 760 mmHg Melting Point 300ºC Molecular Formula C6H13NO2 Molecular Weight 131.173 Flash Point 95.3±22.6 °C Exact Mass 131.094635 PSA 63.32000 LogP 0.92 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.465 InChIKey LRQKBLKVPFOOQJ-YFKPBYRVSA-N SMILES CCCCC(N)C(=O)O |
| Use of | L-Norleucine is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity. Properties Articles36 Name Hexanoic acid, 2-amino-, (S) Synonym More Synonyms L-Norleucine Biological Activity Description L-Norleucine is an isomer of leucine, specifically affects protein synthesis in skeletal muscle, and has antivirus activity. Related Catalog Research Areas >> Infection Natural Products >> Others Human Endogenous Metabolite References [1]. Schott KJ, et al. On the role of branched-chain amino acids in protein turnover of skeletal muscle. Studies in vivo with L-norleucine. Z Naturforsch C. 1985 May-Jun;40(5-6):427-37. [2]. He T, et al. The homeostasis-maintaining metabolites from bacterial stress response to bacteriophage infection suppress tumor metastasis. Oncogene. 2018 Jun 20. Chemical & Physical Properties Molecular Formula C6H13NO2 Exact Mass 131.094635 PSA 63.32000 Index of Refraction 1.465 InChIKey LRQKBLKVPFOOQJ-YFKPBYRVSA-N SMILES CCCCC(N)C(=O)O |
| Tax Rebate | 9.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | P. Quarantine of entry animals, plants, and animal and plant products Q. Quarantine of exit animals, plants, and animal and plant products R. Hygiene supervision and inspection of imported food S. Hyg |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available The above information is believed to be correct, but is not all-inclusive and should be used as a guide only. The information in this document is based on our current knowledge and is Correct safety instructions apply to this product. This information does not represent a warranty as to the properties of this product. See reverse side of invoice or packing slip. |
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