CAS Number316-81-4
Synonyms2-Dimethylsulfamoyl-10-<3-(4-methyl-piperazin-1-yl)-propyl>-phenothiazin; 10-[3-(4-methyl-piperazin-1-yl)-propyl]-10H-phenothiazine-2-sulfonic acid dimethylamide; Majeptyl; Megeptil; Thioproperazine; Sulfenazin; N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide; 10-<3-(4-Methyl-piperazin-1-yl)-propyl>-phenothiazin-2-sulfonsaeure-dimethylamid; Cephalmin; Thioperazine; Mazeptyl; Thioproperazin; thiproperazine; Vontil; Tioproferazina
Molecular FormulaC22H30N4O2S2
Molecular Weight446.638
Purity98.00%
Density1.237g/cm3
Boiling Point612.2ºC at 760mmHg
Melting Point140ºC
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 316-81-4 |
| Catalog No. | 2A-9021233 |
| Chinese Name | 硫丙拉嗪 |
| Synonyms | 2-Dimethylsulfamoyl-10-<3-(4-methyl-piperazin-1-yl)-propyl>-phenothiazin; 10-[3-(4-methyl-piperazin-1-yl)-propyl]-10H-phenothiazine-2-sulfonic acid dimethylamide; Majeptyl; Megeptil; Thioproperazine; Sulfenazin; N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide; 10-<3-(4-Methyl-piperazin-1-yl)-propyl>-phenothiazin-2-sulfonsaeure-dimethylamid; Cephalmin; Thioperazine; Mazeptyl; Thioproperazin; thiproperazine; Vontil; Tioproferazina |
| Molecular Formula | C22H30N4O2S2 |
| Molecular Weight | 446.638 |
| Purity | 98.00 |
| Density | 1.237g/cm3 |
| Boiling Point | 612.2ºC at 760mmHg |
| Melting Point | 140ºC |
| Storage Condition | Room temperature, dry and sealed |
| Application | Thipromazine (RP 7843) is an orally active antipsychotic drug with sedative and antiemetic effects. Thipromazine can effectively promote the release of dopamine in the striatum of rats. Thipromazine c |
| HTC | 2935009090 |
| MDL Number | MFCD00867741 |
| SMILES | CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1 |
| InChI | InChI=1S/C22H30N4O2S2/c1-23(2)30(27,28)18-9-10-22-20(17-18)26(19-7-4-5-8-21(19)29-22)12-6-11-25-15-13-24(3)14-16-25/h4-5,7-10,17H,6,11-16H2,1-3H3 |
| InChI Key | VZYCZNZBPPHOFY-UHFFFAOYSA-N |
| MSDS | msds/21233_1_316_81_4.pdf |
| Use of | Thioproperazine (RP 7843) is an orally active antipsychotic agent with calming, antiemetic activity. Thioproperazine is effective in promoting the release of dopamine in rat striatum. Thioproperazine can be used in studies of schizophrenia and bipolar disorder[1]. Properties Name thioproperazine Synonym More Synonyms Thioproperazine Biological Activity Description Thioproperazine (RP 7843) is an orally active antipsychotic agent with calming, antiemetic activity. Thioproperazine is effective in promoting the release of dopamine in rat striatum. Thioproperazine can be used in studies of schizophrenia and bipolar disorder[1]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Chemical & Physical Properties Molecular Formula C22H30N4O2S2 Exact Mass 446.18100 PSA 80.78000 LogP 4.19870 Index of Refraction 1.615 InChIKey VZYCZNZBPPHOFY-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Phenothiazine-2-sulfonamide, N,N-dimethyl-10-(3-(4-methyl-1-piperazinyl)propyl)- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C22-H30-N4-O2-S2 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T C666 BN ISJ ESWN1&1 B3- AT6N DNTJ D1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - antipsychotic TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral SEX/DURATION : female 1-8 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) MUTATION DATA TEST SYSTEM : Rodent - mouse DOSE/DURATION : REFERENCE : CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974- Volume(issue)/page/year: 9(5),14,1975 Safety Information HS Code 2935009090 Synthetic Route 4-((2-AMINOPHEN... CAS#:5510-56-5 Thioproperazine CAS#:316-81-4 Literature: Pharmaceutical Chemistry Journal, , vol. 8, # 5 p. 286 - 290 Khimiko-Farmatsevticheskii Zhurnal, , vol. 8, # 5 p. 23 - 28 N-[2-[4-(dimeth... CAS#:53106-13-1 Thioproperazine CAS#:316-81-4 Literature: Pharmaceutical Chemistry Journal, , vol. 8, # 5 p. 286 - 290 Khimiko-Farmatsevticheskii Zhurnal, , vol. 8, # 5 p. 23 - 28 CAS#:53106-12-0 Thioproperazine CAS#:316-81-4 Literature: Pharmaceutical Chemistry Journal, , vol. 8, # 5 p. 286 - 290 Khimiko-Farmatsevticheskii Zhurnal, , vol. 8, # 5 p. 23 - 28 Precursor & DownStream Precursor 4 CAS#:5510-56-5 4-((2-AMINOPHEN... CAS#:53106-13-1 N-[2-[4-(dimeth... CAS#:1217018-61-5 N-(3-chloroprop... CAS#:1090-78-4 N,N-Dimethyl-10... DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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