CAS Number309-29-5
SynonymsDoxapramum; Dopram; 1-Ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-2-pyrrolidinone; 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one; Doxapram HCL; doxapram; UNII:94F3830Q73; 1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one; doxapram hydrochloride
Molecular FormulaC24H30N2O2
Molecular Weight378.519
Purity98.00%
Density1.1±0.1 g/cm3
Boiling Point536.4±50.0 °C at 760 mmHg
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 309-29-5 |
| Catalog No. | 2A-9021210 |
| Chinese Name | 多沙普仑 |
| Synonyms | Doxapramum; Dopram; 1-Ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-2-pyrrolidinone; 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one; Doxapram HCL; doxapram; UNII:94F3830Q73; 1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one; doxapram hydrochloride |
| Molecular Formula | C24H30N2O2 |
| Molecular Weight | 378.519 |
| Purity | 98.00 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 536.4±50.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | -20℃ |
| Application | Doxapram can inhibit TASK-1, TASK-3 and TASK-1/TASK-3 heterodimer channels, with EC50 of 410 nM, 37 μM and 9 μM respectively. |
| HTC | 2934999090 |
| MDL Number | MFCD00242721 |
| SMILES | CCN1CC(CCN2CCOCC2)C(c2ccccc2)(c2ccccc2)C1=O |
| InChI | InChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,22H,2,13-19H2,1H3 |
| InChI Key | XFDJYSQDBULQSI-UHFFFAOYSA-N |
| MSDS | msds/21210_1_309_29_5.pdf |
| Use of | Properties Name doxapram Synonym More Synonyms Doxapram Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Neurological Disease References [1]. Cotten JF, et al. The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration. Anesth Analg, 2006, 102(3), 779-785. [2]. Peers, C., Effects of doxapram on ionic currents recorded in isolated type I cells of the neonatal rat carotid body. Brain Res, 1991. 568(1-2): p. 116-22. [3]. Anderson-Beck, R., et al., Doxapram stimulates dopamine release from the intact rat carotid body in vitro. Neurosci Lett, 1995. 187(1): p. 25-8. Chemical & Physical Properties Molecular Formula C24H30N2O2 Exact Mass 378.230713 PSA 32.78000 Index of Refraction 1.562 InChIKey XFDJYSQDBULQSI-UHFFFAOYSA-N Storage condition -20℃ Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 2-Pyrrolidinone, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C24-H30-N2-O2 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) REFERENCE : TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous 1800 ug/kg SEX/DURATION : female 16 week(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - other effects to embryo REFERENCE : BJOGAS British Journal of Obstetrics and Gynaecology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.82- 1975- Volume(issue)/page/year: 84,48,1977 Safety Information HS Code 2934999090 Synthetic Route Total: 1 Page 2-Pyrrolidinone... CAS#:113-07-5 CAS#:309-29-5 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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