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Esculetin structure, CAS 305-01-1

Esculetin

CAS Number305-01-1

SynonymsAesculetin; Cryptotanshinone; ESCULETOL; CICHERINGENIN; Cichorigenin; Asculetine; Esculatin; 6,7-Dihydroxycoumarin; Esculin aglycon; 6,7-Dihydroxy-2H-chromen-2-one; esculetin; 6,7-dihydroxy-2H-1-benzopyran-2-one; MFCD00006874; EINECS 206-161-5

Molecular FormulaC9H6O4

Molecular Weight178.14

Purity98%

Density1.6±0.1 g/cm3

Boiling Point469.7±45.0 °C at 760 mmHg

Melting Point271-273 °C (lit.)

Flash Point

Appearancepowder

EINECS206-161-5

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9021193 Purity: 98%
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Quality Control of [ 305-01-1 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number305-01-1
Catalog No.2A-9021193
Chinese Name秦皮乙素
SynonymsAesculetin; Cryptotanshinone; ESCULETOL; CICHERINGENIN; Cichorigenin; Asculetine; Esculatin; 6,7-Dihydroxycoumarin; Esculin aglycon; 6,7-Dihydroxy-2H-chromen-2-one; esculetin; 6,7-dihydroxy-2H-1-benzopyran-2-one; MFCD00006874; EINECS 206-161-5
Molecular FormulaC9H6O4
Molecular Weight178.14
Purity98
Density1.6±0.1 g/cm3
Boiling Point469.7±45.0 °C at 760 mmHg
Melting Point271-273 °C (lit.)
Appearancepowder
Water Solubilityslightly soluble
Storage Condition2-8°C
PackagingI; II; III
ApplicationEsculetin is an active ingredient extracted primarily from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF)-induced phenotype switching of airway smooth mus
EINECS206-161-5
HTC2932209090
PubChem ID24854815
MDL NumberMFCD00006874
SMILESOc1cc2OC(=O)C=Cc2cc1O
InChI1S/C9H6O4/c10-6-3-5-1-2-9(12)13-8(5)4-7(6)11/h1-4,10-11H
InChI KeyILEDWLMCKZNDJK-UHFFFAOYSA-N
Beilstein/REAXYS152788
NACRES CodeNA.23
UNSPSC12162002
Hazard SymbolsTransport
MSDSmsds/21193_1_305_01_1.pdf
BioactivityEsculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching through inhibition of PI3K/Akt pathway. Esculetin has antioxidant, antiinflammatory, and antitumor activities[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> PI3K/Akt/mTOR >> Akt Target PI3K Akt References [1]. Xie C, et al. Esculetin regulates the phenotype switching of airway smooth muscle cells. Phytother Res. 2019 Aug 21. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 469.7±45.0 °C at 760 mmHg Melting Point 271-273 °C(lit.) Molecular Formula C9H6O4 Molecular Weight 178.141 Flash Point 201.5±22.2 °C Exact Mass 178.026611 PSA 70.67000 LogP 0.98 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.689 Storage condition 2-8°C Water Solubility slightly soluble
Use ofEsculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching through inhibition of PI3K/Akt pathway. Esculetin has antioxidant, antiinflammatory, and antitumor activities[1]. Properties Articles45 Name esculetin Synonym More Synonyms 6,7-Dihydroxycoumarin Biological Activity Description Esculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching through inhibition of PI3K/Akt pathway. Esculetin has antioxidant, antiinflammatory, and antitumor activities[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> PI3K/Akt/mTOR >> Akt References [1]. Xie C, et al. Esculetin regulates the phenotype switching of airway smooth muscle cells. Phytother Res. 2019 Aug 21. Chemical & Physical Properties Molecular Formula C9H6O4 Exact Mass 178.026611 PSA 70.67000 Index of Refraction 1.689 Water Solubility slightly soluble
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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