CAS Number304-20-1
SynonymsAsozart; HYDRALAZINE HYDROCHLORIDE; 1-Hydrazinylphthalazine hydrochloride; Apulon; Phthalazine, 1-hydrazinyl-, hydrochloride (1:1); 1-hydrazinophthalazine hydrochloride; HYDRALAZINE MONOHYDROCHLORIDE; Lopres; EINECS 206-151-0; MFCD00135998; 1-Hydrazinophthalazine hydrochloride (1:1); Hyperazin; Hydrapress; 1-hydrazinophtalazine chlorhydrate; Pressfall; 1-hydrazinyl-Phthalazine hydrochloride; aiselazine; Apresoline; 1-hydrazinylphthalazine hydrochloride (1:1); hydrallazine hydrochloride; apresine; Dralzine; nor-press25; Hydralazine HCl; phthalazin-1-ylhydrazine hydrochloride
Molecular FormulaC8H9ClN4
Molecular Weight196.64
Purity≥99 (TLC)%
Boiling Point491.9ºC at 760 mmHg
Melting Point273 °C
Appearancepowder
EINECS206-151-0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 304-20-1 |
| Catalog No. | 2A-9021187 |
| Chinese Name | 盐酸肼屈嗪 |
| Synonyms | Asozart; HYDRALAZINE HYDROCHLORIDE; 1-Hydrazinylphthalazine hydrochloride; Apulon; Phthalazine, 1-hydrazinyl-, hydrochloride (1:1); 1-hydrazinophthalazine hydrochloride; HYDRALAZINE MONOHYDROCHLORIDE; Lopres; EINECS 206-151-0; MFCD00135998; 1-Hydrazinophthalazine hydrochloride (1:1); Hyperazin; Hydrapress; 1-hydrazinophtalazine chlorhydrate; Pressfall; 1-hydrazinyl-Phthalazine hydrochloride; aiselazine; Apresoline; 1-hydrazinylphthalazine hydrochloride (1:1); hydrallazine hydrochloride; apresine; Dralzine; nor-press25; Hydralazine HCl; phthalazin-1-ylhydrazine hydrochloride |
| Molecular Formula | C8H9ClN4 |
| Molecular Weight | 196.64 |
| Purity | ≥99 (TLC) |
| Boiling Point | 491.9ºC at 760 mmHg |
| Melting Point | 273 °C |
| Appearance | powder |
| Storage Condition | -20?C Freezer |
| Packaging | III |
| Application | Hydralazine hydrochloride is a direct-acting vasodilator and antihypertensive agent. |
| EINECS | 206-151-0 |
| HTC | 2942000000 |
| PubChem ID | 24278461 |
| MDL Number | MFCD00135998 |
| SMILES | Cl[H].N\N=C1/N=NC=C2C=CC=CC12 |
| InChI | 1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5,7H,9H2;1H/b11-8-; |
| InChI Key | SECXUXOCDLQOBI-MKFZHGHUSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1 |
| MSDS | msds/21187_1_304_20_1.pdf |
| Bioactivity | Hydralazine Hydrochloride is a direct-acting vasodilator that is used as an antihypertensive agent.Target: OthersHydralazine (apresoline) is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles. By relaxing vascular smooth muscle, vasodilators act to decrease peripheral resistance, thereby lowering blood pressure and decreasing afterload. However, this only has a short term effect on blood pressure, as the system will reset to the previous, high blood pressure necessary to maintain pressure in the kidney necessary for natriuresis. The long term effect of antihypertensive drugs comes from their effects on the pressure natriuresis curve. It belongs to the hydrazinophthalazine class of drugs [1]. Hydralazine may reduce blood pressure when compared to placebo in patients with primary hypertension, however this data is based on before and after studies, not RCTs. Furthermore, its effect on clinical outcomes remains uncertain [2]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase Research Areas >> Cardiovascular Disease References [1]. Bourreli, B., et al., Additive effects of dihydralazine during enflurane or isoflurane hypotensive anaesthesia for spinal fusion. Can J Anaesth, 1988. 35(3 ( Pt 1)): p. 242-8. [2]. Kandler, M.R., et al., Hydralazine for essential hypertension. Cochrane Database Syst Rev, 2010(8): p. CD004934. Chemical & Physical Properties Boiling Point 491.9ºC at 760 mmHg Melting Point 273°C Molecular Formula C8H9ClN4 Molecular Weight 196.637 Flash Point 251.3ºC Exact Mass 196.051575 PSA 63.10000 LogP 1.72400 InChIKey ZUXNZUWOTSUBMN-UHFFFAOYSA-N SMILES Cl.NNc1nncc2ccccc12 Storage condition -20?C Freezer Stability Stable. Incompatible with strong oxidizing agents. |
| Use of | Hydralazine Hydrochloride is a direct-acting vasodilator that is used as an antihypertensive agent.Target: OthersHydralazine (apresoline) is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles. By relaxing vascular smooth muscle, vasodilators act to decrease peripheral resistance, thereby lowering blood pressure and decreasing afterload. However, this only has a short term effect on blood pressure, as the system will reset to the previous, high blood pressure necessary to maintain pressure in the kidney necessary for natriuresis. The long term effect of antihypertensive drugs comes from their effects on the pressure natriuresis curve. It belongs to the hydrazinophthalazine class of drugs [1]. Hydralazine may reduce blood pressure when compared to placebo in patients with primary hypertension, however this data is based on before and after studies, not RCTs. Furthermore, its effect on clinical outcomes remains uncertain [2]. Properties Articles46 Name hydralazine hydrochloride Synonym More Synonyms Hydralazine hydrochloride Biological Activity Description Hydralazine Hydrochloride is a direct-acting vasodilator that is used as an antihypertensive agent.Target: OthersHydralazine (apresoline) is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles. By relaxing vascular smooth muscle, vasodilators act to decrease peripheral resistance, thereby lowering blood pressure and decreasing afterload. However, this only has a short term effect on blood pressure, as the system will reset to the previous, high blood pressure necessary to maintain pressure in the kidney necessary for natriuresis. The long term effect of antihypertensive drugs comes from their effects on the pressure natriuresis curve. It belongs to the hydrazinophthalazine class of drugs [1]. Hydralazine may reduce blood pressure when compared to placebo in patients with primary hypertension, however this data is based on before and after studies, not RCTs. Furthermore, its effect on clinical outcomes remains uncertain [2]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase Research Areas >> Cardiovascular Disease References [1]. Bourreli, B., et al., Additive effects of dihydralazine during enflurane or isoflurane hypotensive anaesthesia for spinal fusion. Can J Anaesth, 1988. 35(3 ( Pt 1)): p. 242-8. [2]. Kandler, M.R., et al., Hydralazine for essential hypertension. Cochrane Database Syst Rev, 2010(8): p. CD004934. Chemical & Physical Properties Exact Mass 196.051575 PSA 63.10000 LogP 1.72400 InChIKey ZUXNZUWOTSUBMN-UHFFFAOYSA-N Storage condition -20?C Freezer Stability Stable. Incompatible with strong oxidizing agents. |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Hydralazine hydrochloride) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Hydralazine hydrochloride) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Hydralazine hydrochloride) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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