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Arecoline hydrobromide structure, CAS 300-08-3

Arecoline hydrobromide

CAS Number300-08-3

Synonyms1-Methyl-1,2,5,6-tetrahydro-pyridin-3-carbonsaeure-methylester,Hydrobromid; MFCD00039041; Methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrobromide (1:1); EINECS 206-087-3; Arecaidine methyl ester hydrobromide; methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrobromide; 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide (1:1); Arecoline; Methyl 1-methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylate hydrobromide; ARECOLINE HBr; Methyl 1,2,5,6-Tetrahydro-1-methylnicotinate Hydrobromide; Methyl-1-methyl-1,2,5,6-tetrahydro-3-pyridincarboxylathydrobromid; 1-methyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid methyl ester,hydrobromide; arecolinium bromide; Methyl 1-methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylate hydrobromide (1:1); Arecoline hy

Molecular FormulaC8H14BrNO2

Molecular Weight236.11

Purity98.00%

Density

Boiling Point209ºC at 760mmHg

Melting Point172-176 °C (lit.)

Flash Point

AppearanceWhite fine powder

EINECS206-087-3

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9021154 Purity: 98.00%
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Quality Control of [ 300-08-3 ] Purity: 98.00% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number300-08-3
Catalog No.2A-9021154
Chinese Name氢溴酸槟榔碱
Synonyms1-Methyl-1,2,5,6-tetrahydro-pyridin-3-carbonsaeure-methylester,Hydrobromid; MFCD00039041; Methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrobromide (1:1); EINECS 206-087-3; Arecaidine methyl ester hydrobromide; methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate hydrobromide; 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide (1:1); Arecoline; Methyl 1-methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylate hydrobromide; ARECOLINE HBr; Methyl 1,2,5,6-Tetrahydro-1-methylnicotinate Hydrobromide; Methyl-1-methyl-1,2,5,6-tetrahydro-3-pyridincarboxylathydrobromid; 1-methyl-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid methyl ester,hydrobromide; arecolinium bromide; Methyl 1-methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylate hydrobromide (1:1); Arecoline hy
Molecular FormulaC8H14BrNO2
Molecular Weight236.11
Purity98.00
Boiling Point209ºC at 760mmHg
Melting Point172-176 °C (lit.)
AppearanceWhite fine powder
Water SolubilityH2O: 0.1 g/mL, clear, colorless
Storage ConditionStore sealed and protected from light
PackagingIII
ApplicationArecoline hydrobromide is a muscarinic acetylcholine receptor (mAChR) agonist.
EINECS206-087-3
HTC29399990
PubChem ID329753838
MDL NumberMFCD00039041
SMILESBr[H].COC(=O)C1=CCCN(C)C1
InChI1S/C8H13NO2.BrH/c1-9-5-3-4-7(6-9)8(10)11-2;/h4H,3,5-6H2,1-2H3;1H
InChI KeyAXOJRQLKMVSHHZ-UHFFFAOYSA-N
Beilstein/REAXYS3914826
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/21154_1_300_08_3.pdf
BioactivityArecoline Hydrobromide is a muscarinic acetylcholine receptor agonist. Target: mAChRArecoline is an alkaloid found in the areca nut. Arecoline. a drug obtained from the Areca Catechu L., induced a dose-dependent antinociception (0.3-1 mg kg(-1) i.p.) which was prevented by the muscarinic antagonists pirenzepine (0.1 microg per mouse i.c.v.) and S-(-)-ET-126 (0.01 microg per mouse i.c.v.) [1]. Arecoline exerts its excitatory actions by binding to M2-muscarinic receptors on the cell membrane of neurons of the locus coeruleus [2]. Arecoline (1 nM - 1 microM) produced a concentration-dependent contraction in both the longitudinal and the circular smooth muscle of rabbit colon. Atropine (10 microM) abolished the arecoline (80 nM)--induced contraction. M3 receptor antagonist, 4 - DAMP (0.4 microM), abolished the arecoline (80 nM)--related response, whereas M2 receptor antagonist, gallamine (0.4 microM), did not affect the effect of arecoline. These results suggest that arecoline excites the colonic motility via M3 receptor in rabbits [3]. Related Catalog Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Neurological Disease References [1]. Ghelardini, C., et al., M1 receptor activation is a requirement for arecoline analgesia. Farmaco, 2001. 56(5-7): p. 383-5. [2]. Yang, Y.R., et al., Arecoline excites rat locus coeruleus neurons by activating the M2-muscarinic receptor. Chin J Physiol, 2000. 43(1): p. 23-8. [3]. Xie, D.P., et al., Arecoline excites the colonic smooth muscle motility via M3 receptor in rabbits. Chin J Physiol, 2004. 47(2): p. 89-94. Chemical & Physical Properties Boiling Point 209ºC at 760mmHg Melting Point 171-175 °C Molecular Formula C8H14BrNO2 Molecular Weight 236.106 Flash Point 81.1ºC Exact Mass 235.020782 PSA 29.54000 LogP 1.31730 InChIKey AXOJRQLKMVSHHZ-UHFFFAOYSA-N SMILES Br.COC(=O)C1=CCCN(C)C1 Storage condition Refrigerator Water Solubility H2O: 0.1 g/mL, clear, colorless
Use ofProperties Name methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate,hydrobromide Synonym More Synonyms Arecoline hydrobromide Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Neurological Disease References [1]. Ghelardini, C., et al., M1 receptor activation is a requirement for arecoline analgesia. Farmaco, 2001. 56(5-7): p. 383-5. [2]. Yang, Y.R., et al., Arecoline excites rat locus coeruleus neurons by activating the M2-muscarinic receptor. Chin J Physiol, 2000. 43(1): p. 23-8. [3]. Xie, D.P., et al., Arecoline excites the colonic smooth muscle motility via M3 receptor in rabbits. Chin J Physiol, 2004. 47(2): p. 89-94. Chemical & Physical Properties Molecular Formula C8H14BrNO2 Exact Mass 235.020782 PSA 29.54000 LogP 1.31730 InChIKey AXOJRQLKMVSHHZ-UHFFFAOYSA-N SMILES Br.COC(=O)C1=CCCN(C)C1 Storage condition Refrigerator
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: Item 1 Poisons. UN number: 1544 Formal shipping name: Alkaloid, solid, not otherwise specified Packing grade: III
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