CAS Number299-95-6
Synonyms4-{1-Hydroxy-2-[(1-methylethyl)amino]ethyl}benzol-1,2-diolsulfat(2:1)(salt); aleudrin; Novodrine; 4-[1-Hydroxy-2-(isopropylamino)ethyl]benzene-1,2-diol sulfate (2:1); 1,2-Benzenediol, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, sulfate (2:1) (salt); UNII:052RYF6JDD; 4-{1-hydroxy-2-[(1-méthyléthyl)amino]éthyl}benzène-1,2-diol sulfate (2:1) (salt); 4-{1-hydroxy-2-[(1-methylethyl)amino]ethyl}benzene-1,2-diol sulfate (2:1) (salt); 4-[1-Hydroxy-2-(isopropylamino)ethyl]-1,2-benzenediol sulfate (2:1); Isoprenaline Sulfate Dihydrate; EINECS 206-085-2; dl-Isoprenaline sulfate; medihaler-iso; ISO PROTERENOL SULPHATE; Isoproterenol Sulfate Dihydrate; Isoprenaline sulfate; Novodrin; isoprenalinesulfate(2:1); isoprenalinesulphate
Molecular FormulaC22H36N2O10S
Molecular Weight556.62
Purity98.00%
Boiling Point417.5ºC at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 299-95-6 |
| Catalog No. | 2A-9021153 |
| Chinese Name | 消旋硫酸异丙肾上腺素 |
| Synonyms | 4-{1-Hydroxy-2-[(1-methylethyl)amino]ethyl}benzol-1,2-diolsulfat(2:1)(salt); aleudrin; Novodrine; 4-[1-Hydroxy-2-(isopropylamino)ethyl]benzene-1,2-diol sulfate (2:1); 1,2-Benzenediol, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, sulfate (2:1) (salt); UNII:052RYF6JDD; 4-{1-hydroxy-2-[(1-méthyléthyl)amino]éthyl}benzène-1,2-diol sulfate (2:1) (salt); 4-{1-hydroxy-2-[(1-methylethyl)amino]ethyl}benzene-1,2-diol sulfate (2:1) (salt); 4-[1-Hydroxy-2-(isopropylamino)ethyl]-1,2-benzenediol sulfate (2:1); Isoprenaline Sulfate Dihydrate; EINECS 206-085-2; dl-Isoprenaline sulfate; medihaler-iso; ISO PROTERENOL SULPHATE; Isoproterenol Sulfate Dihydrate; Isoprenaline sulfate; Novodrin; isoprenalinesulfate(2:1); isoprenalinesulphate |
| Molecular Formula | C22H36N2O10S |
| Molecular Weight | 556.62 |
| Purity | 98.00 |
| Boiling Point | 417.5ºC at 760 mmHg |
| Water Solubility | almost transparency |
| Storage Condition | Room temperature, dry |
| Application | Isoproterenol hemisulfate is a non-selective β-adrenergic receptor agonist with potent peripheral vasodilator, bronchodilator and cardiac stimulating activities [1][2][3][4][5]. |
| HTC | 2922509090 |
| SMILES | [S](=O)(=O)(O)O.N(C(C)C)CC(O)c2cc(c(cc2)O)O.N(C(C)C)CC(O)c1cc(c(cc1)O)O.O.O |
| InChI | 1S/2C11H17NO3.H2O4S.2H2O/c2*1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;1-5(2,3)4;;/h2*3-5,7,11-15H,6H2,1-2H3;(H2,1,2,3,4);2*1H2 |
| InChI Key | CUQPTVCVZLUXJB-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/21153_1_299_95_6.pdf |
| Bioactivity | Isoprenaline hemisulfate is a non-selective β-adrenergic receptor agonist with potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities[1][2][3][4][5]. Related Catalog Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Target Beta-adrenergic receptor Human Endogenous Metabolite In Vitro Isoprenaline (300 nM, 3 min) increases particulate cGMP- and cilostamide-inhibited, low-Km cAMP phosphodiesterase (cAMP-PDE) activity by about 100% in intact rat fat cells[1]. Isoprenaline inhibits insulin-stimulated glucose transport activity in rat adipocytes. Isoprenaline, in the absence of adenosine, promotes a time-dependent (t1/2 approximately 2 min) decrease in the accessibility of insulin-stimulated cell surface GLUT4 of > 50%, which directly correlated with the observed inhibition of transport activity[2]. Isoprenaline (5 nM and 10 μM) increases cyclic AMP levels and this effect is potentiated by cilostamide (10 mM), by rolipram, a cyclic AMP-specific PDE (PDE 4) inhibitor (10 mM) and by cyclic GMP-elevating agents (50 nM ANF or 30 nM SNP plus 100 nM DMPPO)[3]. Isoprenaline increases the transcriptional activity of Gi alpha-2 gene to 140% of the control value, whereas gene specific hybridization for Gs alpha remains unchanged[4]. Isoprenaline (20 nM) increases the amplitude of total iK and causes a negative shift of approximately 10 mV in the activation curve for iK, both in the absence and in the presence of 300 nM nisoldipine to block the L-type Ca2+ current. Isoprenaline (20 nM) increases the spontaneous pacemaker rate of sino-atrial node pacemaker cells by 16% in rabbit isolated pacemaker cells[5]. References [1]. Degerman E, et al. Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation. Proc Natl Acad Sci U S A. 1990 Jan;87(2):533-7. [2]. Vannucci SJ, et al. Cell surface accessibility of GLUT4 glucose transporters in insulin-stimulated rat adipose cells. Modulation by isoprenaline and adenosine. Biochem J. 1992 Nov 15;288 (Pt 1):325-30. [3]. Delpy E, et al. Effects of cyclic GMP elevation on isoprenaline-induced increase in cyclic AMP and relaxation in rat aortic smooth muscle: role of phosphodiesterase 3. Br J Pharmacol. 1996 Oct;119(3):471-8. [4]. Muller FU, et al. Isoprenaline stimulates gene transcription of the inhibitory G protein alpha-subunit Gi alpha-2 in rat heart. Circ Res. 1993 Mar;72(3):696-700. [5]. Lei M, et al. Modulation of delayed rectifier potassium current, iK, by isoprenaline in rabbit isolated pacemaker cells. Exp Physiol. 2000 Jan;85(1):27-35. Chemical & Physical Properties Boiling Point 417.5ºC at 760 mmHg Molecular Formula C22H36N2O10S Molecular Weight 520.594 Flash Point 179.7ºC Exact Mass 520.209045 PSA 228.42000 LogP 3.46820 Vapour Pressure 1.02E-07mmHg at 25°C InChIKey CUQPTVCVZLUXJB-UHFFFAOYSA-N SMILES CC(C)NCC(O)c1ccc(O)c(O)c1.CC(C)NCC(O)c1ccc(O)c(O)c1.O.O.O=S(=O)(O)O Water Solubility almost transparency |
| Use of | Isoprenaline hemisulfate is a non-selective β-adrenergic receptor agonist with potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities[1][2][3][4][5]. Properties Name Isoprenaline sulphate Synonym More Synonyms UNII:052RYF6JDD Biological Activity Description Isoprenaline hemisulfate is a non-selective β-adrenergic receptor agonist with potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities[1][2][3][4][5]. Related Catalog Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Beta-adrenergic receptor Human Endogenous Metabolite References [1]. Degerman E, et al. Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation. Proc Natl Acad Sci U S A. 1990 Jan;87(2):533-7. [3]. Delpy E, et al. Effects of cyclic GMP elevation on isoprenaline-induced increase in cyclic AMP and relaxation in rat aortic smooth muscle: role of phosphodiesterase 3. Br J Pharmacol. 1996 Oct;119(3):471-8. [4]. Muller FU, et al. Isoprenaline stimulates gene transcription of the inhibitory G protein alpha-subunit Gi alpha-2 in rat heart. Circ Res. 1993 Mar;72(3):696-700. [5]. Lei M, et al. Modulation of delayed rectifier potassium current, iK, by isoprenaline in rabbit isolated pacemaker cells. Exp Physiol. 2000 Jan;85(1):27-35. Chemical & Physical Properties Molecular Formula C22H36N2O10S Exact Mass 520.209045 PSA 228.42000 LogP 3.46820 InChIKey CUQPTVCVZLUXJB-UHFFFAOYSA-N Water Solubility almost transparency |
| Tax Rebate | 13.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Neotetrazolium chloride | 298-95-3 | 2A-9021145 |
| 5-Methylphenazinium methosulfate | 299-11-6 | 2A-9021147 |
| Potassium gluconate | 299-27-4 | 2A-9021148 |
| Calcium gluconate | 299-28-5 | 2A-9021149 |
| Ferrous gluconate | 299-29-6 | 2A-9021150 |
| Arecoline hydrobromide | 300-08-3 | 2A-9021154 |
| Allylbenzene | 300-57-2 | 2A-9021158 |
| Hydroxyaluminum distearate | 300-92-5 | 2A-9021160 |
| Oleamide | 301-02-0 | 2A-9021161 |
| Stannous octoate | 301-10-0 | 2A-9021163 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS