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Home > Products > Pharmaceuticals & Life Science > API & Advanced Intermediates > (11-Oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid; Erythromycin
(11-Oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid; Erythromycin structure, CAS 114-07-8

(11-Oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid; Erythromycin

CAS Number114-07-8

SynonymsROBIMYCIN; UNII-63937KV33D; Theramycin Z; E-BASE; Inderm; Erythromast 36; ERYMAX; Retcin; Ak-Mycin; Ery-Diolan; Eryhexal; Ery-Tab; E.E.S; Erythromycin; EMU; Torlamicina; PCE; MFCD00084654; Paediathrocin; Erycen; Erycin; Erycinum; ERYTHROPED; Erythrogran; Aknemycin; Eritrocina; E-MYCIN; erythromycine; Aknin; ILOTYCIN

Molecular FormulaC37H67NO13

Molecular Weight733.93

Purity98%

Density1.2±0.1 g/cm3

Boiling Point818.4±65.0 °C at 760 mmHg

Melting Point133 °C

Flash Point

Appearancepowder

EINECS204-040-1

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9000021 Purity: 98%
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Quality Control of [ 114-07-8 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number114-07-8
Catalog No.2A-9000021
Chinese Name红霉素
SynonymsROBIMYCIN; UNII-63937KV33D; Theramycin Z; E-BASE; Inderm; Erythromast 36; ERYMAX; Retcin; Ak-Mycin; Ery-Diolan; Eryhexal; Ery-Tab; E.E.S; Erythromycin; EMU; Torlamicina; PCE; MFCD00084654; Paediathrocin; Erycen; Erycin; Erycinum; ERYTHROPED; Erythrogran; Aknemycin; Eritrocina; E-MYCIN; erythromycine; Aknin; ILOTYCIN
Molecular FormulaC37H67NO13
Molecular Weight733.93
Purity98
Density1.2±0.1 g/cm3
Boiling Point818.4±65.0 °C at 760 mmHg
Melting Point133 °C
Appearancepowder
Water SolubilityWater solubility: Practically insoluble; easily so
Storage ConditionStore in inert gas; avoid moisture (moisture absor
ApplicationErythromycin is an oral macrolide antibiotic produced by Streptomyces erythromycin, which reversibly binds to bacterial 50s ribosomes and inhibits protein synthesis.
EINECS204-040-1
HTC2941500000
PubChem ID24894612
MDL NumberMFCD00084654
SMILESCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
InChI1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1
InChI KeyULGZDMOVFRHVEP-RWJQBGPGSA-N
Beilstein/REAXYS75279
NACRES CodeNA.76
UNSPSC12352207
Hazard SymbolsTransport
MSDSmsds/21_1_114_07_8.pdf
BioactivityErythromycin, an oral macrolide antibiotic produced by Streptomyces erythreus, reversibly binds to the 50S ribosome of bacteria, and inhibits protein synthesis.Target: AntibacterialErythromycin is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often prescribed for people who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including Mycoplasma and legionellosis. It was first marketed by Eli Lilly and Company, and it is today commonly known as EES (erythromycin ethylsuccinate, an ester prodrug that is commonly administered). It is also occasionally used as a prokinetic agent.Erythromycin estolate has been associated with reversible hepatotoxicity in pregnant women in the form of elevated serum glutamic-oxaloacetic transaminase and is not recommended during pregnancy. Some evidence suggests similar hepatotoxicity in other populations. Erythromycin displays bacteriostatic activity or inhibits growth of bacteria, especially at higher concentrations, but the mechanism is not fully understood. By binding to the 50s subunit of the bacterial 70s rRNA complex, protein synthesis and subsequent structure and function processes critical for life or replication are inhibited. Erythromycin interferes with aminoacyl translocation, preventing the transfer of the tRNA bound at the A site of the rRNA complex to the P site of the rRNA complex. Without this translocation, the A site remains occupied and, thus, the addition of an incoming tRNA and its attached amino acid to the nascent polypeptide chain is inhibited. This interferes with the production of functionally useful proteins, which is the basis of this antimicrobial action. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection Natural Products >> Others References [1]. McCormack WM, et al. Hepatotoxicity of erythromycin estolate during pregnancy. Antimicrob Agents Chemother. 1977 Nov;12(5):630-5. [2]. Peeters T, et al. Erythromycin is a motilin receptor agonist. Am J Physiol. 1989 Sep;257(3 Pt 1):G470-4. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 818.4±65.0 °C at 760 mmHg Melting Point 138-140ºC Molecular Formula C37H67NO13 Molecular Weight 733.927 Flash Point 448.8±34.3 °C Exact Mass 733.461243 PSA 193.91000 LogP 2.83 Vapour Pressure 0.0±0.6 mmHg at 25°C Index of Refraction 1.535
Use ofProperties Articles494 Name Erythromycin Synonym More Synonyms Erythromycin Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection Natural Products >> Others References [1]. McCormack WM, et al. Hepatotoxicity of erythromycin estolate during pregnancy. Antimicrob Agents Chemother. 1977 Nov;12(5):630-5. [2]. Peeters T, et al. Erythromycin is a motilin receptor agonist. Am J Physiol. 1989 Sep;257(3 Pt 1):G470-4. Chemical & Physical Properties Molecular Formula C37H67NO13 Exact Mass 733.461243 PSA 193.91000 Index of Refraction 1.535
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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