CAS Number148-72-1
SynonymsMFCD00078497; (3S,4R)-3-Ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydrofuran-2(3H)-one nitrate; Pilocarpine nitrate; EINECS 205-723-7
Molecular FormulaC11H17N3O5
Molecular Weight271.27
Purity98.00%
Boiling Point520.5ºC at 760 mmHg
Melting Point173,5-174°C
Appearancecrystals
EINECS205-723-7
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 148-72-1 |
| Catalog No. | 2A-9020986 |
| Chinese Name | 硝酸毛果芸香碱 |
| Synonyms | MFCD00078497; (3S,4R)-3-Ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydrofuran-2(3H)-one nitrate; Pilocarpine nitrate; EINECS 205-723-7 |
| Molecular Formula | C11H17N3O5 |
| Molecular Weight | 271.27 |
| Purity | 98.00 |
| Boiling Point | 520.5ºC at 760 mmHg |
| Melting Point | 173,5-174°C |
| Appearance | crystals |
| Water Solubility | H2O: 0.1 g/mL, clear, very faintly yellow |
| Storage Condition | Store in a dry and cool place. |
| Packaging | III |
| Application | Pilocarpine nitrate is a selective M3 muscarinic receptor agonist. |
| EINECS | 205-723-7 |
| HTC | 2934999090 |
| PubChem ID | 24898116 |
| MDL Number | MFCD00078497 |
| SMILES | O[N+]([O-])=O.CC[C@H]1[C@H](COC1=O)Cc2cncn2C |
| InChI | 1S/C11H16N2O2.HNO3/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;2-1(3)4/h5,7-8,10H,3-4,6H2,1-2H3;(H,2,3,4)/t8-,10-;/m0./s1 |
| InChI Key | PRZXEPJJHQYOGF-GNAZCLTHSA-N |
| Beilstein/REAXYS | 4171406 |
| NACRES Code | NA.21 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/20986_1_148_72_1.pdf |
| Use of | Properties Articles56 Name Pilocarpine nitrate salt Synonym More Synonyms Pilocarpine nitrate Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Neurological Disease In Vivo The Pilocarpine-induced saliva secretion of the control rats (CN) and exercised (EX) rats is examined. A significantly greater amount of saliva is induced by Pilocarpine in the EX rats than in the CN rats (P<0.01). Conversely, the Na+ concentration in the saliva of the EX rats is significantly lower than that of the CN rats (P<0.05)[1]. References [1]. Matsuzaki K, et al. Daily voluntary exercise enhances pilocarpine-induced saliva secretion and aquaporin 1 expression in rat submandibular glands. FEBS Open Bio. 2017 Dec 7;8(1):85-93. [2]. Yuan XL, et al. Cytotoxicity of pilocarpine to human corneal stromal cells and its underlying cytotoxic mechanisms. Int J Ophthalmol. 2016 Apr 18;9(4):505-11. [3]. Tonta MA, et al. Pilocarpine-induced relaxation of rat tail artery by a non-cholinergic mechanism and in the absence of an intact endothelium. Br J Pharmacol. 1994 Jun;112(2):525-32. Chemical & Physical Properties Molecular Formula C11H17N3O5 Exact Mass 271.11700 PSA 110.17000 LogP 1.33730 InChIKey PRZXEPJJHQYOGF-GNAZCLTHSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Pilocarpine, mononitrate CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C11-H16-N2-O2.H-N-O3 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T5OVTJ C2 D1- ET5N CNJ A1 &WNO HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - fluid intake Kidney, Ureter, Bladder - urine volume decreased TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - urine volume increased Related to Chronic Data - death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SEX/DURATION : female 1-22 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - skin and skin appendages TYPE OF TEST : Micronucleus test TYPE OF TEST : Mutation test systems - not otherwise specified MUTATION DATA TEST SYSTEM : Rodent - mouse DOSE/DURATION : REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 344,103,1995 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81934 No. of Facilities: 42 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 980 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81934 No. of Facilities: 22 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1525 (estimated) No. of Female Employees: 1273 (estimated) Safety Information Signal Word Danger Hazard Statements H300 + H330 Precautionary Statements Missing Phrase - N15.00950417-P260-P304 + P340 + P310-P403 + P233 Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges Hazard Codes Xn: Harmful; Risk Phrases R22 Safety Phrases S1-S25-S45 RIDADR 3087 WGK Germany 3 RTECS TK1455000 Packaging Group III Hazard Class 6.1(b) HS Code 2934999090 Synthetic Route Total: 1 Page CAS#:1192231-13-2 Pilocarpine nitrate CAS#:148-72-1 Literature: Tetrahedron, , vol. 65, # 39 p. 8283 - 8296 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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