CAS Number134-63-4
Synonyms2-[6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenylethanone hydrochloride (1:1); Lobelin hydrochloride; Lobeline hydrochloride; EINECS 205-150-2; 2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl}-1-phenylethanone hydrochloride; MFCD00082455; Ethanone, 2-[6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenyl-, hydrochloride (1:1); 2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl}-1-phenylethanonhydrochlorid; α-Lobeline hydrochloride; (-)-Lobeline hydrochloride; 2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phényléthyl]-1-méthyl-2-pipéridinyl}-1-phényléthanone chlorhydrate; 2-(6-(2-Hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanone hydrochloride; Lobeline (hydrochloride)
Molecular FormulaC22H28ClNO2
Molecular Weight373.92
Purity98.00%
Boiling Point485.6ºC at 760mmHg
Melting Point183-185 °C (dec.)(lit.)
AppearanceWhite to off-white solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 134-63-4 |
| Catalog No. | 2A-9020731 |
| Chinese Name | 盐酸洛贝林 |
| Synonyms | 2-[6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenylethanone hydrochloride (1:1); Lobelin hydrochloride; Lobeline hydrochloride; EINECS 205-150-2; 2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl}-1-phenylethanone hydrochloride; MFCD00082455; Ethanone, 2-[6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenyl-, hydrochloride (1:1); 2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl}-1-phenylethanonhydrochlorid; α-Lobeline hydrochloride; (-)-Lobeline hydrochloride; 2-{(2R,6S)-6-[(2S)-2-Hydroxy-2-phényléthyl]-1-méthyl-2-pipéridinyl}-1-phényléthanone chlorhydrate; 2-(6-(2-Hydroxy-2-phenylethyl)-1-methylpiperidin-2-yl)-1-phenylethanone hydrochloride; Lobeline (hydrochloride) |
| Molecular Formula | C22H28ClNO2 |
| Molecular Weight | 373.92 |
| Purity | 98.00 |
| Boiling Point | 485.6ºC at 760mmHg |
| Melting Point | 183-185 °C (dec.)(lit.) |
| Appearance | White to off-white solid |
| Water Solubility | H2O: 25 mg/mL |
| Storage Condition | Keep the receptacle sealed, stored in a cool, dry |
| Packaging | III |
| Application | Lobeline hydrochloride is a nicotinic receptor agonist that acts as a potent neuronal nicotinic receptor α3β2 and α4β2 antagonist. |
| MDL Number | C22H27NO2·HCl |
| SMILES | CN1C(CC(=O)c2ccccc2)CCCC1CC(O)c1ccccc1.Cl |
| InChI | InChI=1S/C22H27NO2.ClH/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18;/h2-7,9-12,19-21,24H,8,13-16H2,1H3;1H/t19-,20+,21-;/m0./s1 |
| InChI Key | MKMYPTLXLWOUSO-HWAJWLCKSA-N |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/20731_1_134_63_4.pdf |
| Bioactivity | Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease Natural Products >> Alkaloid Chemical & Physical Properties Boiling Point 485.6ºC at 760mmHg Melting Point 183-185 °C (dec.)(lit.) Molecular Formula C22H28ClNO2 Molecular Weight 373.916 Flash Point 247.5ºC Exact Mass 373.180847 PSA 40.54000 LogP 4.97590 Vapour Pressure 3.02E-11mmHg at 25°C Index of Refraction -57.5 ° (C=1, H2O) InChIKey MKMYPTLXLWOUSO-HWAJWLCKSA-N SMILES CN1C(CC(=O)c2ccccc2)CCCC1CC(O)c1ccccc1.Cl Storage condition Store at RT Water Solubility H2O: 25 mg/mL |
| Use of | Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes. Properties Name α-Lobeline Hydrochcloride Synonym More Synonyms α-Lobeline Hydrochcloride Biological Activity Description Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease Natural Products >> Alkaloid Chemical & Physical Properties Exact Mass 373.180847 PSA 40.54000 LogP 4.97590 InChIKey MKMYPTLXLWOUSO-HWAJWLCKSA-N Storage condition Store at RT |
| Transport Info | Product name: Lobeline hydrochloride |
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| Piperine | 94-62-2 | 2A-9017861 |
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| Quinine hydrochloride | 130-89-2 | 2A-9020658 |
| Quinine | 130-95-0 | 2A-9020659 |
| DL-Ephedrine hydrochloride | 134-71-4 | 2A-9020732 |
| Ephedrine sulfate | 134-72-5 | 2A-9020733 |
| Pilocarpine nitrate | 148-72-1 | 2A-9020986 |
| DL-Norephedrine hydrochloride | 154-41-6 | 2A-9021037 |
| Ephedrine | 299-42-3 | 2A-9021152 |
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