CAS Number144-82-1
SynonymsMFCD00053363; 4-Amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide; Sulfamethizole; Sulfarine; EINECS 205-641-1; Sulphamethizole
Molecular FormulaC9H10N4O2S2
Molecular Weight270.33
Purity≥99 (HPLC)%
Density1.6±0.1 g/cm3
Boiling Point504.9±52.0 °C at 760 mmHg
Melting Point210 °C
AppearanceWhite to light yellow crystalline powder
EINECS205-641-1
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 144-82-1 |
| Catalog No. | 2A-9020952 |
| Chinese Name | 磺胺甲二唑 |
| Synonyms | MFCD00053363; 4-Amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide; Sulfamethizole; Sulfarine; EINECS 205-641-1; Sulphamethizole |
| Molecular Formula | C9H10N4O2S2 |
| Molecular Weight | 270.33 |
| Purity | ≥99 (HPLC) |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 504.9±52.0 °C at 760 mmHg |
| Melting Point | 210 °C |
| Appearance | White to light yellow crystalline powder |
| Storage Condition | Store at 2-8ºC. |
| Application | Sulfamethizole is a sulfathiazole antibiotic that inhibits bacterial PABA. |
| EINECS | 205-641-1 |
| HTC | 2935009090 |
| PubChem ID | 329824459 |
| MDL Number | MFCD00053363 |
| SMILES | Cc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1 |
| InChI | 1S/C9H10N4O2S2/c1-6-11-12-9(16-6)13-17(14,15)8-4-2-7(10)3-5-8/h2-5H,10H2,1H3,(H,12,13) |
| InChI Key | VACCAVUAMIDAGB-UHFFFAOYSA-N |
| Beilstein/REAXYS | 255002 |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/20952_1_144_82_1.pdf |
| Bioactivity | Sulfamethizole is a sulfathiazole antibacterial agent.Target: AntibacterialSulfamethizole is a sulfathiazole antibacterial agent. Sulfamethizole is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid. Sulfamethizole, an inhibitor of dihydropteroate synthetase and the formation of folic acid, inhibited bioluminescence more than growth [1]. Treatment with sulfamethizole resulted in a significant reduction in bacterial counts in all samples from a susceptible strain (MIC, 128 micro g/ml) and a resistant strain (MIC, 512 micro g/ml). Infection with a sulII gene-positive strain (MIC, >2,048 micro g/ml) could not be treated with sulfamethizole, as no effect could be demonstrated in the urine, bladder, or kidneys [2]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1 Research Areas >> Infection References [1]. Watanabe, H. and J.W. Hastings, Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine. Biochim Biophys Acta, 1990. 1017(3): p. 229-34. [2]. Kerrn, M.B., N. Frimodt-Moller, and F. Espersen, Effects of sulfamethizole and amdinocillin against Escherichia coli strains (with various susceptibilities) in an ascending urinary tract infection mouse model. Antimicrob Agents Chemother, 2003. 47(3): p. 1002-9. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 504.9±52.0 °C at 760 mmHg Melting Point 210 °C Molecular Formula C9H10N4O2S2 Molecular Weight 270.331 Flash Point 259.1±30.7 °C Exact Mass 270.024506 PSA 134.59000 LogP 0.51 Vapour Pressure 0.0±1.3 mmHg at 25°C Index of Refraction 1.687 InChIKey VACCAVUAMIDAGB-UHFFFAOYSA-N SMILES Cc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1 Storage condition 2-8°C |
| Use of | Properties Articles37 Name sulfamethizole Synonym More Synonyms Sulfamethizole Biological Activity Related Catalog Research Areas >> Infection References [1]. Watanabe, H. and J.W. Hastings, Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine. Biochim Biophys Acta, 1990. 1017(3): p. 229-34. [2]. Kerrn, M.B., N. Frimodt-Moller, and F. Espersen, Effects of sulfamethizole and amdinocillin against Escherichia coli strains (with various susceptibilities) in an ascending urinary tract infection mouse model. Antimicrob Agents Chemother, 2003. 47(3): p. 1002-9. Chemical & Physical Properties Molecular Formula C9H10N4O2S2 Exact Mass 270.024506 PSA 134.59000 Index of Refraction 1.687 InChIKey VACCAVUAMIDAGB-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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