CAS Number144-48-9
SynonymsMFCD00008028; carbamoylmethyl iodide; 2-Iodo-acetamide; USAF D-1; Monoiodoacetamide; 2-iodoacetamido; Iodoacetamide; ACETAMIDE,2-IODO; 2-Iodoacetamide; Surauto; EINECS 205-630-1
Molecular FormulaICH2CONH2
Molecular Weight184.96
Purity≥99 (NMR)%
Density2.3±0.1 g/cm3
Boiling Point297.1±23.0 °C at 760 mmHg
Melting Point92-95 °C (lit.)
Appearancepowder
EINECS205-630-1
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 144-48-9 |
| Catalog No. | 2A-9020944 |
| Chinese Name | 碘代乙酰胺 |
| Synonyms | MFCD00008028; carbamoylmethyl iodide; 2-Iodo-acetamide; USAF D-1; Monoiodoacetamide; 2-iodoacetamido; Iodoacetamide; ACETAMIDE,2-IODO; 2-Iodoacetamide; Surauto; EINECS 205-630-1 |
| Molecular Formula | ICH2CONH2 |
| Molecular Weight | 184.96 |
| Purity | ≥99 (NMR) |
| Density | 2.3±0.1 g/cm3 |
| Boiling Point | 297.1±23.0 °C at 760 mmHg |
| Melting Point | 92-95 °C (lit.) |
| Appearance | powder |
| Water Solubility | slightly soluble |
| Storage Condition | Store at 2-8ºC. |
| Packaging | III |
| Application | 2-Iodoacetamide (Iodoacetamide) is a commonly used alkylating agent that is often used to alkylate cysteine during proteomics sample preparation. |
| EINECS | 205-630-1 |
| HTC | 2924199090 |
| PubChem ID | 24278486 |
| MDL Number | MFCD00008028 |
| SMILES | NC(=O)CI |
| InChI | 1S/C2H4INO/c3-1-2(4)5/h1H2,(H2,4,5) |
| InChI Key | PGLTVOMIXTUURA-UHFFFAOYSA-N |
| Beilstein/REAXYS | 1739080 |
| NACRES Code | NA.77 |
| UNSPSC | 12352202 |
| Hazard Symbols | 6.1 |
| MSDS | msds/20944_1_144_48_9.pdf |
| Bioactivity | 2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics[1][2]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others In Vivo 2-Iodoacetamide (2.0-10 mg; drinking; daily; 20-93 days) feeding always produces chronic deep ulcers in the secretory part of the rat stomach[2]. Animal Model: Sprague-Dawley rats[2] Dosage: 2.0-10 mg Administration: Drinking water, daily, for periods of 20 to 93 days Result: Produced gastritis which was further complicated by chronic ulceration in many of the test rats. References [1]. Peter G Hains, et al. The Impact of Commonly Used Alkylating Agents on Artifactual Peptide Modification. J Proteome Resq. 2017 Sep 1;16(9):3443-3447. [2]. J J LALICH. Iodoacetamide induced gastric ulcers in rats. Proc Soc Exp Biol Med. 1962 Apr;109:905-8. Chemical & Physical Properties Density 2.3±0.1 g/cm3 Boiling Point 297.1±23.0 °C at 760 mmHg Melting Point 92-95 °C(lit.) Molecular Formula C2H4INO Molecular Weight 184.964 Flash Point 133.5±22.6 °C Exact Mass 184.933746 PSA 43.09000 LogP -0.19 Vapour Pressure 0.0±0.6 mmHg at 25°C Index of Refraction 1.602 InChIKey PGLTVOMIXTUURA-UHFFFAOYSA-N SMILES NC(=O)CI Storage condition 2-8°C Stability Stable, but light sensitive. Incompatible with strong oxidizing agents, strong bases, reducing agents, acids. Water Solubility slightly soluble |
| Use of | 2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics[1][2]. Properties Articles569 Name 2-Iodoacetamide Synonym More Synonyms Iodoacetamide Biological Activity Description 2-Iodoacetamide (Iodoacetamide), an alkylating agent, is a commonly used agent for alkylation of cysteine during sample preparation for proteomics[1][2]. Related Catalog Research Areas >> Others Signaling Pathways >> Others >> Others References [1]. Peter G Hains, et al. The Impact of Commonly Used Alkylating Agents on Artifactual Peptide Modification. J Proteome Resq. 2017 Sep 1;16(9):3443-3447. [2]. J J LALICH. Iodoacetamide induced gastric ulcers in rats. Proc Soc Exp Biol Med. 1962 Apr;109:905-8. Chemical & Physical Properties Molecular Formula C2H4INO Exact Mass 184.933746 PSA 43.09000 LogP -0.19 Index of Refraction 1.602 InChIKey PGLTVOMIXTUURA-UHFFFAOYSA-N SMILES NC(=O)CI Stability Stable, but light sensitive. Incompatible with strong oxidizing agents, strong bases, reducing agents, acids. Water Solubility slightly soluble |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (2-Iodoacetamide) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (2-Iodoacetamide) International air transport hazard regulations: Toxic solid, organic, n.o.s. (2-Iodoacetamide) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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