CAS Number134-96-3
SynonymsEINECS 205-167-5; Syringic Aldehyde; 4-Hydroxy-3,5-dimethoxybenzaldehyde; 4-Hydroxy-3,5-dimethoxybenzolcarbaldehyd; Syringaldehyde; 3,5-Dimethoxy-4-Hydroxybenzaldehyde; MFCD00006943
Molecular FormulaHOC6H2(OCH3)2CHO
Molecular Weight182.17
Purity98%
Density1.2±0.1 g/cm3
Boiling Point192-193 °C/14 mmHg (lit.)
Melting Point110-113 °C (lit.)
AppearanceLight yellow-green to brown crystalline powder
EINECS205-167-5
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 134-96-3 |
| Catalog No. | 2A-9020739 |
| Chinese Name | 3,5-二甲氧基-4-羟基苯甲醛； 丁香醛 |
| Synonyms | EINECS 205-167-5; Syringic Aldehyde; 4-Hydroxy-3,5-dimethoxybenzaldehyde; 4-Hydroxy-3,5-dimethoxybenzolcarbaldehyd; Syringaldehyde; 3,5-Dimethoxy-4-Hydroxybenzaldehyde; MFCD00006943 |
| Molecular Formula | HOC6H2(OCH3)2CHO |
| Molecular Weight | 182.17 |
| Purity | 98 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 192-193 °C/14 mmHg (lit.) |
| Melting Point | 110-113 °C (lit.) |
| Appearance | Light yellow-green to brown crystalline powder |
| Water Solubility | very sparingly soluble |
| Storage Condition | Room Temperature |
| Packaging | I; II; III |
| Application | Syringaldehyde is a flavonoid polyphenolic compound found in different plant species, such as Manihot esculenta and Magnolia officinalis[1]. Syringaldehyde moderately inhibits COX-2 activity with an I |
| EINECS | 205-167-5 |
| HTC | 29124900 |
| PubChem ID | 24899757 |
| MDL Number | MFCD00006943 |
| SMILES | COc1cc(C=O)cc(OC)c1O |
| InChI | 1S/C9H10O4/c1-12-7-3-6(5-10)4-8(13-2)9(7)11/h3-5,11H,1-2H3 |
| InChI Key | KCDXJAYRVLXPFO-UHFFFAOYSA-N |
| Beilstein/REAXYS | 784514 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | Transport |
| MSDS | msds/20739_1_134_96_3.pdf |
| Bioactivity | Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis[1]. Syringaldehyde moderately inhibits COX-2 activity with an IC50 of 3.5 μg/mL[2]. Anti-hyperglycemic and anti-inflammatory activities[1]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> COX Natural Products >> Flavonoids Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Target COX-2:19.2 μM (IC50) In Vitro Syringaldehyde inhibits COX-2 activity in a dosedependent manner with an IC50 of 3.5 μg/mL[2]. In Vivo Syringaldehyde exerts anti-hyperglycemic effect in rat model of diabetes induced by streptozotocin. Apart from antioxidant capability, Syringaldehyde also has anti-inflammatory activity as it is found to have inhibitory action on cyclo-oxygenase 2 (COX-2) in mouse macrophage cell line[1]. Animal Admin Rats[1] Adult male albino wistar rats (weighing 180-220 g) 12.5 mg/kg, 25 mg/kg, and 50 mg/kg; p.o.; for 21 days Adult male albino wistar rats are randomly divided into six groups (n=6), first group serves as control and receives vehicle (orally) for 21 days. Second group is given Syringaldehyde in saline orally at 50 mg/kg for 21 days. Third group receives vehicle for a period of 21 days and then ISO (100 mg/kg, s.c.) on 20th and 21 st day at an interval of 24 h. Fourth group is given Syringaldehyde for 21 days at 12.5 mg/kg, p.o. and ISO on 20th and 21 st day. Fifth group receives Syringaldehyde at concentration of 25 mg/kg, p.o. for 21 days and ISO on 20th and 21 st day. The sixth group is treated with 50 mg/kg of Syringaldehyde for 21 days and ISO on 20th and 21 st day. During the experimental procedure body weight of animals are monitored and on 22nd day, 24 h after second injection of ISO, rats sre sacrificed by cervical decapitation. Note: Body weight of animals belonging to different groups did not differed significantly but heart weight of ISO challenged animals were highly elevated (p ≤ 0.05) than control rats. However, treatment of rats with Syringaldehyde significantly reduced heart weight in dose dependent way. The rats treated with Syringaldehyde alone displayed an insignificant difference from control group. References [1]. Shahzad S, et al. Protective effect of syringaldehyde on biomolecular oxidation, inflammation and histopathological alterations in isoproterenol induced cardiotoxicity in rats. Biomed Pharmacother. 2018 Dec;108:625-633. [2]. Stanikunaite R, et al. Cyclooxygenase-2 inhibitory and antioxidant compounds from the truffle Elaphomyces granulatus. Phytother Res. 2009 Apr;23(4):575-8. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 322.1±37.0 °C at 760 mmHg Melting Point 110-113 °C(lit.) Molecular Formula C9H10O4 Molecular Weight 182.173 Flash Point 130.1±20.0 °C Exact Mass 182.057907 PSA 55.76000 LogP 0.86 Vapour Pressure 0.0±0.7 mmHg at 25°C Index of Refraction 1.568 InChIKey KCDXJAYRVLXPFO-UHFFFAOYSA-N SMILES COc1cc(C=O)cc(OC)c1O Water Solubility very sparingly soluble |
| Use of | Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis[1]. Syringaldehyde moderately inhibits COX-2 activity with an IC50 of 3.5 μg/mL[2]. Anti-hyperglycemic and anti-inflammatory activities[1]. Properties Articles45 Name syringaldehyde Synonym More Synonyms Syringaldehyde Biological Activity Description Syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis[1]. Syringaldehyde moderately inhibits COX-2 activity with an IC50 of 3.5 μg/mL[2]. Anti-hyperglycemic and anti-inflammatory activities[1]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> COX Natural Products >> Flavonoids Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease COX-2:19.2 μM (IC50) In Vitro Syringaldehyde inhibits COX-2 activity in a dosedependent manner with an IC50 of 3.5 μg/mL[2]. In Vivo Syringaldehyde exerts anti-hyperglycemic effect in rat model of diabetes induced by streptozotocin. Apart from antioxidant capability, Syringaldehyde also has anti-inflammatory activity as it is found to have inhibitory action on cyclo-oxygenase 2 (COX-2) in mouse macrophage cell line[1]. References [1]. Shahzad S, et al. Protective effect of syringaldehyde on biomolecular oxidation, inflammation and histopathological alterations in isoproterenol induced cardiotoxicity in rats. Biomed Pharmacother. 2018 Dec;108:625-633. [2]. Stanikunaite R, et al. Cyclooxygenase-2 inhibitory and antioxidant compounds from the truffle Elaphomyces granulatus. Phytother Res. 2009 Apr;23(4):575-8. Chemical & Physical Properties Molecular Formula C9H10O4 Exact Mass 182.057907 PSA 55.76000 Index of Refraction 1.568 InChIKey KCDXJAYRVLXPFO-UHFFFAOYSA-N Water Solubility very sparingly soluble |
| Tax Rebate | 9.0% |
| Supervision | None. MFN tariff: 5.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 0.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
| Related Products in Functional Building Blocks | ||
|---|---|---|
| Propionaldehyde | 123-38-6 | 2A-9019511 |
| Crotonaldehyde | 123-73-9 | 2A-9019528 |
| Decanedihydrazide | 125-83-7 | 2A-9020548 |
| 1,4,5,8-Naphthalenetetracarboxylic acid | 128-97-2 | 2A-9020624 |
| Trichlormethiazide | 133-67-5 | 2A-9020713 |
| Methyclothiazide | 135-07-9 | 2A-9020742 |
| Sodium cyclohexanecarboxylate | 136-01-6 | 2A-9020766 |
| 1,5-Diphenylcarbazide | 140-22-7 | 2A-9020837 |
| Cyanoacetohydrazide | 140-87-4 | 2A-9020857 |
| Acetylenedicarboxylic acid | 142-45-0 | 2A-9020907 |
| Browse all Functional Building Blocks products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS