CAS Number133-67-5
Synonyms2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide; Metahydrin; Trichloromethiazide; Diu-Hydrin; Esmarin; Triflumen; Achletin,Diu-Hydrin,Triflumen; Carvacron; Diurese; MFCD00057315; Achletin; Salurin; Tolcasone; Kubacron; 6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Anatran; Flutra; Trichlormethiazide; Naqua; EINECS 205-118-8; Anistadin; Tachionin; 3-Dichloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide; Fluitran; 6-Chloro-3-dichloromethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide
Molecular FormulaC8H8Cl3N3O4S2
Molecular Weight380.66
Purity98.00%
Density1.7±0.1 g/cm3
Boiling Point631.3±65.0 °C at 760 mmHg
Melting Point248-250ºC
AppearanceWhite-off-white crystal-powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 133-67-5 |
| Catalog No. | 2A-9020713 |
| Chinese Name | 三氯噻嗪 |
| Synonyms | 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide; Metahydrin; Trichloromethiazide; Diu-Hydrin; Esmarin; Triflumen; Achletin,Diu-Hydrin,Triflumen; Carvacron; Diurese; MFCD00057315; Achletin; Salurin; Tolcasone; Kubacron; 6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Anatran; Flutra; Trichlormethiazide; Naqua; EINECS 205-118-8; Anistadin; Tachionin; 3-Dichloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide; Fluitran; 6-Chloro-3-dichloromethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide |
| Molecular Formula | C8H8Cl3N3O4S2 |
| Molecular Weight | 380.66 |
| Purity | 98.00 |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 631.3±65.0 °C at 760 mmHg |
| Melting Point | 248-250ºC |
| Appearance | White-off-white crystal-powder |
| Storage Condition | Room Temperature |
| Application | Trichlormethiazide is a thiazide diuretic. |
| HTC | 2935009090 |
| PubChem ID | 329751386 |
| MDL Number | MFCD00057315 |
| SMILES | NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C(Cl)Cl)cc1Cl |
| InChI | 1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16) |
| InChI Key | LMJSLTNSBFUCMU-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/20713_1_133_67_5.pdf |
| Bioactivity | Trichlormethiazide is a thiazide diuretic with properties similar to those of hydrochlorothiazide.Target: OthersTrichlormethiazide is a diuretic with properties similar to those of hydrochlorothiazide. It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension. In veterinary medicine, trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal limbs and general bruising. Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle. This results in excretion of sodium, chloride and water, and thus acts as a diuretic [1-3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Metabolic Disease References [1]. Fuchs, M., B.E. Newman, and R.H. Seller, The clinical pharmacology of trichlormethiazide (Naqua). Curr Ther Res Clin Exp, 1961. 3: p. 116-24. [2]. Reisman, E.E., Jr., Clinical experience with trichlormethiazide in edema. Angiology, 1963. 14: p. 59-63. [3]. West, R.O., A clinical and statistical study of the effect of trichlormethiazide on blood pressure. Med Ann Dist Columbia, 1962. 31: p. 574-7. Chemical & Physical Properties Density 1.7±0.1 g/cm3 Boiling Point 631.3±65.0 °C at 760 mmHg Melting Point 248-250ºC Molecular Formula C8H8Cl3N3O4S2 Molecular Weight 380.656 Flash Point 335.6±34.3 °C Exact Mass 378.902191 PSA 135.12000 LogP 0.24 Vapour Pressure 0.0±1.8 mmHg at 25°C Index of Refraction 1.625 InChIKey LMJSLTNSBFUCMU-UHFFFAOYSA-N SMILES NS(=O)(=O)c1cc2c(cc1Cl)NC(C(Cl)Cl)NS2(=O)=O |
| Use of | Trichlormethiazide is a thiazide diuretic with properties similar to those of hydrochlorothiazide.Target: OthersTrichlormethiazide is a diuretic with properties similar to those of hydrochlorothiazide. It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension. In veterinary medicine, trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal limbs and general bruising. Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle. This results in excretion of sodium, chloride and water, and thus acts as a diuretic [1-3]. Properties Name Trichlormethiazide Synonym More Synonyms Trichlormethiazide Biological Activity Description Trichlormethiazide is a thiazide diuretic with properties similar to those of hydrochlorothiazide.Target: OthersTrichlormethiazide is a diuretic with properties similar to those of hydrochlorothiazide. It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension. In veterinary medicine, trichlormethiazide can be combined with dexamethasone to be used on horses with mild swelling of distal limbs and general bruising. Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle. This results in excretion of sodium, chloride and water, and thus acts as a diuretic [1-3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Metabolic Disease References [1]. Fuchs, M., B.E. Newman, and R.H. Seller, The clinical pharmacology of trichlormethiazide (Naqua). Curr Ther Res Clin Exp, 1961. 3: p. 116-24. [2]. Reisman, E.E., Jr., Clinical experience with trichlormethiazide in edema. Angiology, 1963. 14: p. 59-63. [3]. West, R.O., A clinical and statistical study of the effect of trichlormethiazide on blood pressure. Med Ann Dist Columbia, 1962. 31: p. 574-7. Chemical & Physical Properties Exact Mass 378.902191 PSA 135.12000 Index of Refraction 1.625 InChIKey LMJSLTNSBFUCMU-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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