CAS Number129-03-3
Synonymscyproheptadiene; EINECS 204-928-9; Dronactin; Periactine; Periactinol; MFCD00242817; Eiproheptadine; Cyproheptadine; 1-methyl-4-(5-dibenzo[a,e]cycloheptatrienylidene)piperidine; MK 141; 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine; Periactin; Cypoheptadine; 4-dibenzo[a,d]cyclohepten-5-ylidene-1-methyl-piperidine; Periactin(R)
Molecular FormulaC21H21N1
Molecular Weight287.4
Purity98.00%
Density1.115g/cm3
Boiling Point440.1ºC at 760mmHg
Melting Point298 °C (dec.)(lit.)
AppearanceColorless liquid, sweet, almond smell
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 129-03-3 |
| Catalog No. | 2A-9020626 |
| Chinese Name | 塞庚啶 |
| Synonyms | cyproheptadiene; EINECS 204-928-9; Dronactin; Periactine; Periactinol; MFCD00242817; Eiproheptadine; Cyproheptadine; 1-methyl-4-(5-dibenzo[a,e]cycloheptatrienylidene)piperidine; MK 141; 4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine; Periactin; Cypoheptadine; 4-dibenzo[a,d]cyclohepten-5-ylidene-1-methyl-piperidine; Periactin(R) |
| Molecular Formula | C21H21N1 |
| Molecular Weight | 287.4 |
| Purity | 98.00 |
| Density | 1.115g/cm3 |
| Boiling Point | 440.1ºC at 760mmHg |
| Melting Point | 298 °C (dec.)(lit.) |
| Appearance | Colorless liquid, sweet, almond smell |
| Packaging | I; II; III |
| Application | Cyproheptadine is an orally available 5-HT2A receptor antagonist with antidepressant and antiseptic effects. Cyproheptadine has antiplatelet and thromboprotective activities. Cyproheptadine can be use |
| HTC | 29143900 |
| MDL Number | MFCD00242817 |
| SMILES | CN1CCC(=C2c3ccccc3C=Cc3ccccc32)CC1 |
| InChI Key | JJCFRYNCJDLXIK-UHFFFAOYSA-N |
| MSDS | msds/20626_1_129_03_3.pdf |
| Use of | Cyproheptadine is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine has antiplatelet and thromboprotective activities. Cyproheptadine can be used for the research of thromboembolic disorders[1][2]. Properties Name cyproheptadine Synonym More Synonyms Cyproheptadine Biological Activity Description Cyproheptadine is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine has antiplatelet and thromboprotective activities. Cyproheptadine can be used for the research of thromboembolic disorders[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cardiovascular Disease Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor References [1]. Calka O, et, al. Effect of cyproheptadine on serum leptin levels. Adv Ther, 2005. 22(5): p. 424-8. [2]. Olivia A Lin, et al. The Antidepressant 5-HT2A Receptor Antagonists Pizotifen and Cyproheptadine Inhibit Serotonin-Enhanced Platelet Function. PLoS One. 2014; 9(1): e87026. Chemical & Physical Properties Exact Mass 323.14400 PSA 3.24000 LogP 5.43780 Index of Refraction 1.5339 (20ºC) InChIKey JJCFRYNCJDLXIK-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Piperidine, 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methyl- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : WISWESSER LINE NOTATION : L C676 BYJ BU- DT6N DYTJ A1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,69,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,69,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 43300 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,69,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 25,1723,1975 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973 Volume(issue)/page/year: -,82,1973 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 3500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,69,1972 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : female 10 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 257,168,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : female 13 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 257,168,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SEX/DURATION : female 10 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 257,168,1982 Safety Information Packaging Group I; II; III HS Code 29143900 Synthetic Route 5-(1-Methyl-4-P... CAS#:3967-32-6 Cyproheptadine CAS#:129-03-3 Literature: Hatano, Manabu; Ito, Orie; Suzuki, Shinji; Ishihara, Kazuaki Journal of Organic Chemistry, 2010 , vol. 75, # 15 p. 5008 - 5016 Dibenzosuberenone CAS#:2222-33-5 Cyproheptadine CAS#:129-03-3 Literature: Archiv der Pharmazie, , vol. 329, # 2 p. 87 - 94 ethyl 4-(5H-dib... CAS#:121138-82-7 Cyproheptadine CAS#:129-03-3 Literature: Tetrahedron, , vol. 44, # 19 p. 6197 - 6200 Precursor & DownStream Precursor 5 CAS#:3967-32-6 5-(1-Methyl-4-P... CAS#:2222-33-5 Dibenzosuberenone CAS#:121138-82-7 ethyl 4-(5H-dib... CAS#:29976-53-2 N-Carbethoxy-4-... DownStream 2 CAS#:14051-46-8 desmethylcyproh... CAS#:54191-04-7 cyproheptadine ... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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