CAS Number127-56-0
SynonymsSulfacetamide sodium salt; Sodium acetyl[(4-aminophenyl)sulfonyl]azanide; UNII-30760ZE777; Sulfacetamide sodium anhydrous; Sulfacetamide sodium; acetamide, N-[(4-aminophenyl)sulfonyl]-, monosodium salt; SODIUM SULFACETAMIDE; Sulf 10; MFCD00149555; Acetamide, N-[(4-aminophenyl)sulfonyl]-, sodium salt (1:1); N-Acetylsulfanilamide Sodium Salt Hydrate; Sodium N-sulfanilylacetamide; SULPHACETAMIDE SODIUM; N-Acetyl-4-aminobenzenesulfonamide Sodium Salt Hydrate; sodium,acetyl-(4-aminophenyl)sulfonylazanide; EINECS 204-848-4; SulfacetaMide SodiuM Salt Hydrate; Sulfacetamide (Sodium)
Molecular FormulaC8H9N2NaO3S
Molecular Weight236.223
Purity98.00%
Boiling Point450.8ºC at 760 mmHg
AppearanceSolid;White to Almost white powder to crystal
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 127-56-0 |
| Catalog No. | 2A-9020585 |
| Chinese Name | 磺胺乙酰钠 |
| Synonyms | Sulfacetamide sodium salt; Sodium acetyl[(4-aminophenyl)sulfonyl]azanide; UNII-30760ZE777; Sulfacetamide sodium anhydrous; Sulfacetamide sodium; acetamide, N-[(4-aminophenyl)sulfonyl]-, monosodium salt; SODIUM SULFACETAMIDE; Sulf 10; MFCD00149555; Acetamide, N-[(4-aminophenyl)sulfonyl]-, sodium salt (1:1); N-Acetylsulfanilamide Sodium Salt Hydrate; Sodium N-sulfanilylacetamide; SULPHACETAMIDE SODIUM; N-Acetyl-4-aminobenzenesulfonamide Sodium Salt Hydrate; sodium,acetyl-(4-aminophenyl)sulfonylazanide; EINECS 204-848-4; SulfacetaMide SodiuM Salt Hydrate; Sulfacetamide (Sodium) |
| Molecular Formula | C8H9N2NaO3S |
| Molecular Weight | 236.223 |
| Purity | 98.00 |
| Boiling Point | 450.8ºC at 760 mmHg |
| Appearance | Solid;White to Almost white powder to crystal |
| Water Solubility | Water solubility: soluble |
| Packaging | III |
| Application | Sulfacetamide sodium is an anti-inflammatory compound that acts on skin and urinary tract infections. |
| HTC | 2924299090 |
| SMILES | [Na]N([S](=O)(=O)c1ccc(cc1)N)C(=O)C |
| InChI | 1S/C8H10N2O3S.Na/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8;/h2-5H,9H2,1H3,(H,10,11);/q;+1/p-1 |
| InChI Key | PQMSFAORUFMASU-UHFFFAOYSA-M |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/20585_1_127_56_0.pdf |
| Use of | Sulfacetamide Sodium is an anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections.Target: AntibacterialSulfacetamide is a sulfonamide antibiotic. Sulfacetamide is able to inhibit the growth of all isolated strains. Depending on the type of bacteria concentrations of 0.006 up to 6.4% sodium sulfacetamide proved to be effective. Simultaneously, all patients were treated with sulfacetamide containing ointment and/or eye drops 4 times daily for maximum of 14 days. With swabs taken at intervals of 7 and 14 days no bacterial growth was detected. Sulfacetamide 10% topical lotion, sold under the brand name Klaron or Ovace, is approved for the treatment of acne and seborrheic dermatitis. Sulfacetamide has been investigated for use in the treatment of pityriasis versicolor and rosacea. It may also have anti-inflammatory properties when used to treat blepharitis or conjunctivitis. It is believed to work by limiting the presence of folic acid which bacteria need to survive. It has been suggested that sulfacetamide may also serve as a treatment for mild forms of hidradenitis suppurativa. Sulfacetamide has antibacterial activity and is used to control acne. Some research indicates that sulfacetamide derivatives may act as antifungals by an CYP51A1-independent mechanism [1-4]. Properties Name sulfacetamide sodium anhydrous Synonym More Synonyms Sulfacetamide sodium Biological Activity Description Sulfacetamide Sodium is an anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections.Target: AntibacterialSulfacetamide is a sulfonamide antibiotic. Sulfacetamide is able to inhibit the growth of all isolated strains. Depending on the type of bacteria concentrations of 0.006 up to 6.4% sodium sulfacetamide proved to be effective. Simultaneously, all patients were treated with sulfacetamide containing ointment and/or eye drops 4 times daily for maximum of 14 days. With swabs taken at intervals of 7 and 14 days no bacterial growth was detected. Sulfacetamide 10% topical lotion, sold under the brand name Klaron or Ovace, is approved for the treatment of acne and seborrheic dermatitis. Sulfacetamide has been investigated for use in the treatment of pityriasis versicolor and rosacea. It may also have anti-inflammatory properties when used to treat blepharitis or conjunctivitis. It is believed to work by limiting the presence of folic acid which bacteria need to survive. It has been suggested that sulfacetamide may also serve as a treatment for mild forms of hidradenitis suppurativa. Sulfacetamide has antibacterial activity and is used to control acne. Some research indicates that sulfacetamide derivatives may act as antifungals by an CYP51A1-independent mechanism [1-4]. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Del Rosso, J.Q., Evaluating the role of topical therapies in the management of rosacea: focus on combination sodium sulfacetamide and sulfur formulations. Cutis, 2004. 73(1 Suppl): p. 29-33. [2]. Mastrolorenzo, A. and C.T. Supuran, Antifungal Activity of Ag(I) and Zn(II) Complexes of Sulfacetamide Derivatives. Met Based Drugs, 2000. 7(1): p. 49-54. [3]. http://www.drugs.com/mtm/klaron.html [4]. Roth, H.W., et al., [The effective antibacterial spectrum of sulfacetamide]. Klin Monbl Augenheilkd, 1992. 200(3): p. 182-6. Chemical & Physical Properties Molecular Formula C8H9N2NaO3S Exact Mass 236.023163 PSA 88.85000 LogP 1.93230 InChIKey PQMSFAORUFMASU-UHFFFAOYSA-M Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Acetamide, N-sulfanilyl-, monosodium salt CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C8-H9-N2-O3-S.Na MOLECULAR WEIGHT : WISWESSER LINE NOTATION : ZR DSWMV1 &-NA- HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : REFERENCE : RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione Umana. Review of Science and Technology of Food and Human Nutrition. (Bologna, Italy) V.5-6, 1975-76. Discontinued. Volume(issue)/page/year: 6,161,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83071 No. of Facilities: 176 (estimated) No. of Industries: 5 No. of Occupations: 4 No. of Employees: 500 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83071 No. of Facilities: 185 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 6788 (estimated) No. of Female Employees: 3730 (estimated) Safety Information Signal Word Warning Hazard Statements H315-H319-H335 Precautionary Statements P305 + P351 + P338 Hazard Codes Xi: Irritant; Safety Phrases 26-36 RIDADR UN 3249 WGK Germany 3 RTECS AC8480000 Packaging Group III Hazard Class 6.1(b) HS Code 2924299090 Precursor & DownStream Precursor 0 DownStream 5 CAS#:6325-93-5 4-Nitrobenzenes... CAS#:81865-28-3 methyl N-acetyl... CAS#:81865-29-4 ethyl N-acetyl-... CAS#:81865-31-8 methyl 2-[acety... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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