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Diethyl Safranine structure, CAS 4569-86-2

Diethyl Safranine

CAS Number4569-86-2

SynonymsMethylene violet 3RAX; 3-amino-7-N,N-diethylamino-2-methyl-5-phenyl-phenazinium chloride; MFCD00013433; 3-amino-7-diethylamino-5-phenyl-phenazinium,chloride; methylene violet; N,N-Diethylphenosafranine; 3-Amino-7-diaethylamino-5-phenyl-phenazinium,Chlorid

Molecular FormulaC22H23ClN4

Molecular Weight378.90

Purity>90.0 (HPLC)%

Density

Boiling Point

Melting Point285 °C (dec.) (lit.)

Flash Point

Appearancesolid

EINECS

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-1202327 Purity: >90.0 (HPLC)%
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Quality Control of [ 4569-86-2 ] Purity: >90.0 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number4569-86-2
Catalog No.2A-1202327
Chinese Name亚甲基紫3RAX
SynonymsMethylene violet 3RAX; 3-amino-7-N,N-diethylamino-2-methyl-5-phenyl-phenazinium chloride; MFCD00013433; 3-amino-7-diethylamino-5-phenyl-phenazinium,chloride; methylene violet; N,N-Diethylphenosafranine; 3-Amino-7-diaethylamino-5-phenyl-phenazinium,Chlorid
Molecular FormulaC22H23ClN4
Molecular Weight378.90
Purity>90.0 (HPLC)
Melting Point285 °C (dec.) (lit.)
Appearancesolid
Storage ConditionStore at room temperature, away from light, in a v
ApplicationMethylene Violet 3RAX is a phenazine dye used to stain cell mitochondria. Methylene Violet 3RAX can change the molecular structure of DNA, destroy DNA modules, and induce the production of reactive si
HTC2933990090
PubChem ID24858600
MDL NumberMFCD00013433
SMILES[Cl-].CCN(CC)c1ccc2nc3ccc(N)cc3[n+](-c4ccccc4)c2c1
InChI1S/C22H22N4.ClH/c1-3-25(4-2)18-11-13-20-22(15-18)26(17-8-6-5-7-9-17)21-14-16(23)10-12-19(21)24-20;/h5-15,23H,3-4H2,1-2H3;1H
InChI KeyMOVNSGGBTSIUGX-UHFFFAOYSA-N
NACRES CodeNA.47
UNSPSC12171500
Hazard Symbolstransportation
MSDSmsds/203337_1_4569_86_2.pdf
BioactivityMethylene Violet 3RAX is a phenazine dye to stain the mitochondria of cells. Methylene Violet 3RAX can change the molecular structure of DNA, undermine the module of DNA, and induce the generation of the reactive singlet oxygen. Methylene Violet 3RAX shows inhibition for human erythrocyte AChE and human plasma BChE with an Kis of 1.58, 0.51 μM, respectively. Methylene Violet 3RAX has the potential for the research of potential photosensitizers for mitochondrial targeting action in PDT (photodynamic therapy)[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Neuronal Signaling >> AChE Target Acetylcholinesterase:1.58 μM (Ki) Butyrylcholinesterase:0.51 μM (Ki) In Vitro Methylene Violet 3RAX shows antitumor activity by cutting off DNA strands in tumour cell[1].Methylene Violet 3RAX (0-400 µM) significantly enhances cleavage of DNA with over 60% photocleavage activity towards DNA at 300 μM[1]. References [1]. Si Yao, et al. Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study. RSC Advances. 2022,12, 21004-21013. [2]. Onder S, et al. The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by methylene violet 3RAX. Chem Biol Interact. 2019 Dec 1;314:108845. Chemical & Physical Properties Melting Point 285 °C (dec.)(lit.) Molecular Formula C22H23ClN4 Molecular Weight 378.89800 Exact Mass 378.16100 PSA 46.03000 LogP 1.67830 InChIKey MOVNSGGBTSIUGX-UHFFFAOYSA-N SMILES CCN(CC)c1ccc2nc3ccc(N)cc3[n+](-c3ccccc3)c2c1.[Cl-]
Use ofProperties Name 2-N,2-N-diethyl-10-phenylphenazin-10-ium-2,8-diamine,chloride Synonym More Synonyms ci 50206 Biological Activity Related Catalog Research Areas >> Cancer Signaling Pathways >> Neuronal Signaling >> AChE Acetylcholinesterase:1.58 μM (Ki) Butyrylcholinesterase:0.51 μM (Ki) In Vitro Methylene Violet 3RAX shows antitumor activity by cutting off DNA strands in tumour cell[1].Methylene Violet 3RAX (0-400 µM) significantly enhances cleavage of DNA with over 60% photocleavage activity towards DNA at 300 μM[1]. References [1]. Si Yao, et al. Methylene violet 3RAX-conjugated porphyrin for photodynamic therapy: synthesis, DNA photocleavage, and cell study. RSC Advances. 2022,12, 21004-21013. [2]. Onder S, et al. The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by methylene violet 3RAX. Chem Biol Interact. 2019 Dec 1;314:108845. Chemical & Physical Properties Exact Mass 378.16100 PSA 46.03000 LogP 1.67830 InChIKey MOVNSGGBTSIUGX-UHFFFAOYSA-N
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SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 90.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available
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