| Chemical & Physical Properties | |
|---|---|
| CAS Number | 72593-77-2 |
| Catalog No. | 2A-1200527 |
| Chinese Name | 二乙二醇-2-溴乙基甲醚 |
| Synonyms | 1-[2-(2-bromoethoxy)ethoxy]-2-methoxyethane |
| Molecular Formula | C7H15BrO3 |
| Molecular Weight | 227.10 |
| Purity | 97 |
| Density | 1.288g/cm3 |
| Boiling Point | 245.798ºC at 760 mmHg |
| Appearance | liquid |
| Storage Condition | -20°C, argon-filled storage |
| Application | Methyl-PEG3-bromide is a PROTAC linker and belongs to the PEG class. Can be used to synthesize PROTAC molecules. |
| PubChem ID | 329768300 |
| MDL Number | MFCD00956116 |
| SMILES | BrCCOCCOCCOC |
| InChI | 1S/C7H15BrO3/c1-9-4-5-11-7-6-10-3-2-8/h2-7H2,1H3 |
| InChI Key | LCCCTXULXHJDLA-UHFFFAOYSA-N |
| NACRES Code | NA.23 |
| UNSPSC | 12352103 |
| MSDS | msds/202435_1_72593_77_2.pdf |
| Bioactivity | Methyl-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target PEGs In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Density 1.288g/cm3 Boiling Point 245.798ºC at 760 mmHg Molecular Formula C7H15BrO3 Molecular Weight 227.09600 Flash Point 96.375ºC Exact Mass 226.02000 PSA 27.69000 LogP 1.06090 Index of Refraction 1.451 InChIKey LCCCTXULXHJDLA-UHFFFAOYSA-N SMILES COCCOCCOCCBr |
| Use of | Methyl-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Name Diethylene Glycol 2-Bromoethyl Methyl Ether Synonym More Synonyms Methyl-PEG3-bromide Biological Activity Description Methyl-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Molecular Formula C7H15BrO3 Exact Mass 226.02000 PSA 27.69000 LogP 1.06090 Index of Refraction 1.451 InChIKey LCCCTXULXHJDLA-UHFFFAOYSA-N SMILES COCCOCCOCCBr |
| Transport Info | Product name: Purity: 94.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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