CAS Number110429-45-3
Synonyms1-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-2-methoxyethane; Triethylene Glycol 2-BroMoethyl Methyl Ether; 2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethyl Bromide; 1-Bromo-3,6,9,12-tetraoxatridecane
Molecular FormulaC9H19O4Br1
Molecular Weight271.15
Density1.256g/cm3
Boiling Point296.3ºC at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 110429-45-3 |
| Catalog No. | 2A-1200523 |
| Chinese Name | 三乙二醇2-溴乙基甲醚 |
| Synonyms | 1-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-2-methoxyethane; Triethylene Glycol 2-BroMoethyl Methyl Ether; 2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethyl Bromide; 1-Bromo-3,6,9,12-tetraoxatridecane |
| Molecular Formula | C9H19O4Br1 |
| Molecular Weight | 271.15 |
| Density | 1.256g/cm3 |
| Boiling Point | 296.3ºC at 760 mmHg |
| Storage Condition | 2-8°C |
| Application | m-PEG4-Br is a cleavable ADC linker used for the synthesis of antibody-drug conjugates (ADCs) of trastuzumab (HY-P9907). m-PEG4-Br was placed distal to the monomethyl auristatin E (MMAE) payload to ge |
| PubChem ID | 32054935 |
| MDL Number | MFCD12545963 |
| SMILES | COCCOCCOCCOCCBr |
| InChI | InChI=1S/C9H19BrO4/c1-11-4-5-13-8-9-14-7-6-12-3-2-10/h2-9H2,1H3 |
| InChI Key | YFFFQGXWMHAJPP-UHFFFAOYSA-N |
| MSDS | msds/202431_1_110429_45_3.pdf |
| Bioactivity | m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab (HY-P9907). m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Target Cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. References [1]. Walker JA, et al. Hydrophilic Sequence-Defined Cross-Linkers for Antibody-Drug Conjugates.Bioconjug Chem. 2019 Nov 20;30(11):2982-2988. Chemical & Physical Properties Density 1.256g/cm3 Boiling Point 296.3ºC at 760 mmHg Molecular Formula C9H19BrO4 Molecular Weight 271.14900 Flash Point 118.8ºC Exact Mass 270.04700 PSA 36.92000 LogP 1.07750 Vapour Pressure 0.00256mmHg at 25°C Index of Refraction 1.454 InChIKey YFFFQGXWMHAJPP-UHFFFAOYSA-N SMILES COCCOCCOCCOCCBr Storage condition 2-8°C |
| Use of | m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab (HY-P9907). m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency[1]. Properties Name Triethylene Glycol 2-Bromoethyl Methyl Ether Synonym More Synonyms m-PEG4-Br Biological Activity Description m-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab (HY-P9907). m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. References [1]. Walker JA, et al. Hydrophilic Sequence-Defined Cross-Linkers for Antibody-Drug Conjugates.Bioconjug Chem. 2019 Nov 20;30(11):2982-2988. Chemical & Physical Properties Molecular Formula C9H19BrO4 Exact Mass 270.04700 PSA 36.92000 LogP 1.07750 Index of Refraction 1.454 InChIKey YFFFQGXWMHAJPP-UHFFFAOYSA-N SMILES COCCOCCOCCOCCBr |
| Transport Info | Product name: Purity: 95.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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