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XEN445

Name: XEN445
Brand: 2A Biotech
SKU: 2A-1198792

CAS Number1515856-92-4

Synonyms2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid; (S)-2-(3-(PYRIDIN-2-YLMETHOXY)PYRROLIDIN-1-YL)-5-(TRIFLUOROMETHYL)BENZOIC ACID. HCL; XEN-445; XEN445

Molecular FormulaC18H17F3N2O3

Molecular Weight366.33

Purity≥98 (HPLC)%

Density1.4±0.1 g/cm3

Boiling Point490.9±45.0 °C at 760 mmHg

Appearancepowder

MSDSChinese English

Cat. No.: 2A-1198792 Purity: ≥98 (HPLC)%

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Quality Control of [ 1515856-92-4 ] Purity: ≥98 (HPLC)% SDS Specification MoL

Chemical & Physical Properties
CAS Number	1515856-92-4
Catalog No.	2A-1198792
Chinese Name	2-[(3S)-3-(2-吡啶基甲氧基)-1-吡咯烷基]-5-(三氟甲基)苯甲酸
Synonyms	2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid; (S)-2-(3-(PYRIDIN-2-YLMETHOXY)PYRROLIDIN-1-YL)-5-(TRIFLUOROMETHYL)BENZOIC ACID. HCL; XEN-445; XEN445
Molecular Formula	C18H17F3N2O3
Molecular Weight	366.33
Purity	≥98 (HPLC)
Density	1.4±0.1 g/cm3
Boiling Point	490.9±45.0 °C at 760 mmHg
Appearance	powder
Storage Condition	-20℃
Application	XEN445 is an endothelial lipase (EL) inhibitor with an IC50 of 0.237 uM. It has good ADME and PK activities and can increase the concentration of high-density lipoprotein cholesterol in mouse plasma.
SMILES	FC(F)(F)c1cc(c(cc1)N2C[C@H](CC2)OCc3ncccc3)C(=O)O
InChI	1S/C18H17F3N2O3/c19-18(20,21)12-4-5-16(15(9-12)17(24)25)23-8-6-14(10-23)26-11-13-3-1-2-7-22-13/h1-5,7,9,14H,6,8,10-11H2,(H,24,25)/t14-/m0/s1
InChI Key	NBGRERFNOKZQLO-AWEZNQCLSA-N
NACRES Code	NA.77
UNSPSC	12352200
MSDS	msds/200734_1_1515856_92_4.pdf
Transport Info	Product name: XEN445

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XEN445

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