| Chemical & Physical Properties | |
|---|---|
| CAS Number | 864084-88-8 |
| Catalog No. | 2A-2196864 |
| Chinese Name | L-谷氨酰胺基-L-精氨酰-L-苯丙氨酰-L-丝氨酰-L-精氨酸 |
| Synonyms | human opiorphin; H-Gln-Arg-Phe-Ser-Arg-OH |
| Molecular Formula | C29H48N12O8 |
| Molecular Weight | 692.76700 |
| Appearance | buffered aqueous glycerol solution |
| Storage Condition | room temperature |
| Application | Opiorphin is an opioid peptide and a potent enkephalin that can inactivate zinc exopeptidase in human inhibitors. Opiorphin inhibits two enkephalin catabolic exoenzymes, namely human neutral exopeptid |
| PubChem ID | 57305235 |
| SMILES | NC(=O)CCC(N)C(=O)NC(CCCN=C(N)N)C(=O)NC(Cc1ccccc1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)O |
| InChI | InChI=1S/C29H48N12O8/c30-17(10-11-22(31)43)23(44)38-18(8-4-12-36-28(32)33)24(45)40-20(14-16-6-2-1-3-7-16)25(46)41-21(15-42)26(47)39-19(27(48)49)9-5-13-37-29(34)35/h1-3,6-7,17-21,42H,4-5,8-15,30H2,(H2,31,43)(H,38,44)(H,39,47)(H,40,45)(H,41,46)(H,48,49)(H4,32,33,36)(H4,34,35,37)/t17-,18-,19-,20-,21-/m0/s1 |
| InChI Key | TWWFCOBVAKAKIT-SXYSDOLCSA-N |
| NACRES Code | NA.41 |
| UNSPSC | 12352203 |
| Hazard Symbols | transportation |
| MSDS | msds/198659_1_864084_88_8.pdf |
| Bioactivity | Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC50 value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission[1][2]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Neprilysin In Vitro Opiorphin (1-100 μM; the mouse isolated colon) causes contractile effects in mouse distal colon in a concentration-dependent manner and enhances the contractile response induced by Met-enkephalin[1]. Opiorphin (0-50 μM; hNEP or hAP-N transformed HEK293 cell line) is a dual inhibitor of enkephalin-degrading hNEP and hAP-N in vitro. Opiorphin inhibits Mca-BK2 endoproteolysis by the cell-surface recombinant hNEP with an IC50 value of 33 μM. and inhibits the Ala-pNA cleavage by hAP-N with an IC50 value of 65 μM[2]. In Vivo Opiorphin (1.25-10 μg/kg; ICV; 0-60 min; male Kunming mice) induces potent analgesic effect in a dose- and time-dependent manner (ED50=3.22 μg/kg)[1]. Animal Model: Male Kunming mice[1] Dosage: 1.25, 2.5, 5, 10 μg/kg Administration: Intracerebroventrical injection; post-drug latency measurements were performed at 5, 10, 20, 30, 40, 50 and 60 min Result: Had the percentage change of tail withdrawal latency (TWL) at 10 min after i.c.v. administration of 1.25-10 mg/kg was 28.90%, 44.37%, 56.43% and 91.899.79%, respectively. Chemical & Physical Properties Molecular Formula C29H48N12O8 Molecular Weight 692.76700 Exact Mass 692.37200 PSA 366.84000 LogP 0.71060 InChIKey TWWFCOBVAKAKIT-SXYSDOLCSA-N SMILES NC(=O)CCC(N)C(=O)NC(CCCN=C(N)N)C(=O)NC(Cc1ccccc1)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)O |
| Use of | Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC50 value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission[1][2]. Properties Name Opiorphin Synonym More Synonyms Opiorphin trifluoroacetate salt Biological Activity Description Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC50 value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission[1][2]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Neprilysin Chemical & Physical Properties Molecular Formula C29H48N12O8 Exact Mass 692.37200 PSA 366.84000 LogP 0.71060 InChIKey TWWFCOBVAKAKIT-SXYSDOLCSA-N |
| Transport Info | Product name: Purity: 95.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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