CAS Number252881-74-6
SynonymsH2N-OEG-CO2tBu; tert-butyl 3-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}propanoate; tert-Butyl 3-[2-(2-(2-aminoethoxy)ethoxy)ethoxy]propionate; 12-amino-4,7,10-trioxadodecanoic acid tert-butyl ester; Amin PEG3-t-butyl ester; tert-butyl 12-amino-4,7,10-trioxododecanoate; tert-Butyl 12-amino-4,7,10-trioxadodecanoate; 3-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]propionic acid tert-butyl ester
Molecular FormulaC13H27NO5
Molecular Weight277.36
Purity≥80 (T)%
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 252881-74-6 |
| Catalog No. | 2A-1196598 |
| Chinese Name | 氨基-三聚乙二醇-丙酸叔丁酯 |
| Synonyms | H2N-OEG-CO2tBu; tert-butyl 3-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}propanoate; tert-Butyl 3-[2-(2-(2-aminoethoxy)ethoxy)ethoxy]propionate; 12-amino-4,7,10-trioxadodecanoic acid tert-butyl ester; Amin PEG3-t-butyl ester; tert-butyl 12-amino-4,7,10-trioxododecanoate; tert-Butyl 12-amino-4,7,10-trioxadodecanoate; 3-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]propionic acid tert-butyl ester |
| Molecular Formula | C13H27NO5 |
| Molecular Weight | 277.36 |
| Purity | ≥80 (T) |
| Appearance | solid |
| Storage Condition | -20°C; store under inert gas; avoid light, moistur |
| Application | NH2-PEG3-C2-Boc is a PROTAC linker, belonging to the PEG class. Can be used to synthesize PROTAC molecules. |
| HTC | 2922509090 |
| PubChem ID | 57652942 |
| MDL Number | MFCD06201017 |
| SMILES | CC(C)(C)OC(=O)CCOCCOCCOCCN |
| InChI | 1S/C13H27NO5/c1-13(2,3)19-12(15)4-6-16-8-10-18-11-9-17-7-5-14/h4-11,14H2,1-3H3 |
| InChI Key | CWFSAZJIJBTKRC-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| MSDS | msds/198376_1_252881_74_6.pdf |
| Bioactivity | NH2-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target PEGs In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1] References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. Chemical & Physical Properties Molecular Formula C13H27NO5 Molecular Weight 277.35700 Flash Point 169.7ºC Exact Mass 277.18900 PSA 80.01000 LogP 1.42700 InChIKey CWFSAZJIJBTKRC-UHFFFAOYSA-N SMILES CC(C)(C)OC(=O)CCOCCOCCOCCN |
| Use of | NH2-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Name tert-butyl 3-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]propanoate Synonym More Synonyms NH2-PEG3-C2-Boc Biological Activity Description NH2-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1] References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. Chemical & Physical Properties Molecular Formula C13H27NO5 Exact Mass 277.18900 PSA 80.01000 LogP 1.42700 InChIKey CWFSAZJIJBTKRC-UHFFFAOYSA-N SMILES CC(C)(C)OC(=O)CCOCCOCCOCCN |
| Tax Rebate | 13.0% |
| Supervision | A. Customs clearance form for inbound goods B. Customs clearance form for outbound goods |
| Inspection | R. Hygiene supervision and inspection of imported food S. Hygiene supervision and inspection of exported food |
| Transport Info | Product name: Purity: 95.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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