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1-Azidohexaethylene Glycol structure, CAS 86770-68-5

1-Azidohexaethylene Glycol

CAS Number86770-68-5

Synonyms14-Azido-3,6,9,12-tetraoxatetradecan-1-ol; 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol

Molecular FormulaC10H21N3O5

Molecular Weight263.291

Purity

Density

Boiling Point

Melting Point

Flash Point

AppearanceLiquid;Colorless to Light orange to Yellow clear liquid

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Cat. No.: 2A-1196586 Purity:
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Quality Control of [ 86770-68-5 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number86770-68-5
Catalog No.2A-1196586
Chinese Name14-叠氮-3,6,9,12-四氧十四烷醇
Synonyms14-Azido-3,6,9,12-tetraoxatetradecan-1-ol; 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol
Molecular FormulaC10H21N3O5
Molecular Weight263.291
AppearanceLiquid;Colorless to Light orange to Yellow clear liquid
Storage Condition0-10°C; avoid heating
ApplicationAzido-PEG5-alcohol is a non-cleavable ADC linker containing 5 units of PEG that can be used to synthesize antibody drug conjugates (ADCs). Azido-PEG5-alcohol is also a PROTAC linker, belonging to the
PubChem ID160871202
SMILES[N-]=[N+]=NCCOCCOCCOCCOCCO
InChIInChI=1S/C10H21N3O5/c11-13-12-1-3-15-5-7-17-9-10-18-8-6-16-4-2-14/h14H,1-10H2
InChI KeyJTGGTGKXQQGEHB-UHFFFAOYSA-N
BioactivityAzido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Target PEGs Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Zhang FL, et al. Molecular-target-based anticancer photosensitizer: synthesis and in vitro photodynamic activity of erlotinib-zinc(II) phthalocyanine conjugates. ChemMedChem. 2015 Feb;10(2):312-20. [2]. Nan JI, et al. Mertk degraders and uses thereof. WO2020010210A1. Chemical & Physical Properties Molecular Formula C10H21N3O5 Molecular Weight 263.291 Flash Point 100 °C Exact Mass 263.148132 PSA 106.90000 LogP -1.59 Index of Refraction 1.47 InChIKey JTGGTGKXQQGEHB-UHFFFAOYSA-N SMILES [N-]=[N+]=NCCOCCOCCOCCOCCO
Use ofAzido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Properties Name 14-Azido-3,6,9,12-tetraoxatetradecanol Synonym More Synonyms Azido-PEG5-alcohol Biological Activity Description Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Zhang FL, et al. Molecular-target-based anticancer photosensitizer: synthesis and in vitro photodynamic activity of erlotinib-zinc(II) phthalocyanine conjugates. ChemMedChem. 2015 Feb;10(2):312-20. [2]. Nan JI, et al. Mertk degraders and uses thereof. WO2020010210A1. Chemical & Physical Properties Molecular Formula C10H21N3O5 Exact Mass 263.148132 PSA 106.90000 LogP -1.59 Index of Refraction 1.47 InChIKey JTGGTGKXQQGEHB-UHFFFAOYSA-N SMILES [N-]=[N+]=NCCOCCOCCOCCOCCO
Transport InfoProduct name: Purity: 95.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified
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