| Chemical & Physical Properties | |
|---|---|
| CAS Number | 86770-67-4 |
| Catalog No. | 2A-1196585 |
| Chinese Name | 11-叠氮基-3,6,9-三氧杂十一醇 |
| Synonyms | 1-AZIDO-3,6,9-TRIOXAUNDECANE-11-OL; Azido-PEG4-alcohol; 1-azido-3,6,9-trioxaundecan-11-ol; 1-azido-11-hydroxy-3,6,9-trioxaundecane |
| Molecular Formula | C8H17N3O4 |
| Molecular Weight | 218.25 |
| Purity | ≥90 (GC) |
| Appearance | liquid |
| Storage Condition | 0-10°C; avoid heating |
| Application | Azido-PEG4-alcohol is a PROTAC linker, which belongs to the PEG class and can be used to synthesize PROTAC. |
| PubChem ID | 57647613 |
| MDL Number | MFCD00269874 |
| SMILES | NCCOCCOCCOCCN=[N+]=[N-] |
| InChI | 1S/C8H18N4O3/c9-1-3-13-5-7-15-8-6-14-4-2-11-12-10/h1-9H2 |
| InChI Key | FPVCVHVTMPCZTH-UHFFFAOYSA-N |
| Beilstein/REAXYS | 4745506 |
| NACRES Code | NA.22 |
| UNSPSC | 12352125 |
| MSDS | msds/198363_1_86770_67_4.pdf |
| Bioactivity | Azido-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target PEGs In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228. Chemical & Physical Properties Molecular Formula C8H17N3O4 Molecular Weight 219.23800 Exact Mass 219.12200 PSA 97.67000 Index of Refraction 1.47 InChIKey MBQYGQMGPFNSAP-UHFFFAOYSA-N SMILES [N-]=[N+]=NCCOCCOCCOCCO |
| Use of | Azido-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Properties Name 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol Synonym More Synonyms Azido-PEG4-alcohol Biological Activity Description Azido-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228. Chemical & Physical Properties Molecular Formula C8H17N3O4 Exact Mass 219.12200 PSA 97.67000 Index of Refraction 1.47 InChIKey MBQYGQMGPFNSAP-UHFFFAOYSA-N SMILES [N-]=[N+]=NCCOCCOCCOCCO |
| Transport Info | Product name: Purity: 95.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Azido-PEG7-acid | 361189-66-4 | 2A-1196574 |
| H2N-PEG2-CH2COOtBu | 1122484-77-8 | 2A-1196575 |
| Azido-PEG2-acid | 1312309-63-9 | 2A-1196576 |
| N3-PEG8-CH2CH2COOH | 1214319-92-2 | 2A-1196577 |
| Azido-PEG2-CH2CO2-NHS | 1312309-64-0 | 2A-1196578 |
| 1-Azidohexaethylene Glycol | 86770-68-5 | 2A-1196586 |
| Azido-PEG6 | 86770-69-6 | 2A-1196587 |
| N3-PEG7-OH | 1274892-60-2 | 2A-1196588 |
| 1,14-diamino-3,6,9,12-tetraoxatetradecane | 68960-97-4 | 2A-1196589 |
| 3,6,9,12,15-PENTAOXAHEPTADECANE-1,17-DIYL BIS-AMINE | 72236-26-1 | 2A-1196590 |
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