CAS Number34604-52-9
Synonymsoxydiethane-2,1-diyl dimethanesulfonate; diethyleneglycol bis-methane-sulfonyl ester; dimethyl 3-oxapentane-1,5-disulfonate; di-mesyl-diglyme; Diethylene Glycol Dimesylate; 2,2'-Oxybis-ethanol Dimethanesulfonate
Molecular FormulaC6H14O7S2
Molecular Weight262.3
Density1.389g/cm3
Boiling Point480.2ºC at 760 mmHg
Appearancewhite solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 34604-52-9 |
| Catalog No. | 2A-1196458 |
| Chinese Name | Ms-PEG2-Ms |
| Synonyms | oxydiethane-2,1-diyl dimethanesulfonate; diethyleneglycol bis-methane-sulfonyl ester; dimethyl 3-oxapentane-1,5-disulfonate; di-mesyl-diglyme; Diethylene Glycol Dimesylate; 2,2'-Oxybis-ethanol Dimethanesulfonate |
| Molecular Formula | C6H14O7S2 |
| Molecular Weight | 262.3 |
| Density | 1.389g/cm3 |
| Boiling Point | 480.2ºC at 760 mmHg |
| Appearance | white solid |
| Storage Condition | Room temperature, dry, sealed |
| Application | Ms-PEG2-Ms is a PROTAC linker, belonging to the PEG class. Can be used to synthesize PROTAC molecules. |
| HTC | 2904100000 |
| PubChem ID | 10249668 |
| MDL Number | MFCD01730454 |
| SMILES | CS(=O)(=O)OCCOCCOS(C)(=O)=O |
| InChI | InChI=1S/C6H14O7S2/c1-14(7,8)12-5-3-11-4-6-13-15(2,9)10/h3-6H2,1-2H3 |
| InChI Key | CEGQKEWSEGCYRS-UHFFFAOYSA-N |
| MSDS | msds/198224_1_34604_52_9.pdf |
| Use of | Ms-PEG2-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Name 2-(2-methylsulfonyloxyethoxy)ethyl methanesulfonate Synonym More Synonyms Ms-PEG2-Ms Biological Activity Description Ms-PEG2-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Molecular Formula C6H14O7S2 Exact Mass 262.01800 PSA 112.73000 LogP 1.11700 Index of Refraction 1.47 InChIKey CEGQKEWSEGCYRS-UHFFFAOYSA-N SMILES CS(=O)(=O)OCCOCCOS(C)(=O)=O Safety Information Hazard Codes T+ HS Code 2904100000 Synthetic Route Total: 1 Page Methanesulfonyl... CAS#:124-63-0 Diethylene glycol CAS#:111-46-6 Ms-PEG2-Ms CAS#:34604-52-9 Literature: Catalysis Communications, , vol. 21, p. 96 - 103 Precursor & DownStream Precursor 2 CAS#:124-63-0 Methanesulfonyl... CAS#:111-46-6 Diethylene glycol DownStream 10 CAS#:34270-90-1 2-IODOETHYL ETHER CAS#:92-53-5 4-Phenylmorpholine CAS#:39910-98-0 4-Morpholinoace... CAS#:19614-15-4 ETHYL 4-MORPHOL... |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Product name: Summary 2904100000 derivatives containing only sulpho groups, their salts and ethyl esters. Supervision conditions:None. VAT: 17.0%. Tax rebate rate:9.0%. MFN tariff:5.5%. General tariff:30.0% |
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