CAS Number20601-85-8
SynonymsMLO; 2,2'-dihydroxy-5,5'-dipropylbiphenyl; 5,5'-propyl-2,2'-dihydroxy-1,1'-biphenyl; 5,5'-Dipropyl-2,2'-biphenyldiol; 5.5'-Dipropyl-biphenyl-2.2'-diol; 5,5'-dipropylbiphenyl-2,2'-diol; tetrahydro-magnolol; 6,6'-Dihydroxy-3,3'-dipropyl-biphenyl
Molecular FormulaC18H22O2
Molecular Weight270.37
Density1.1±0.1 g/cm3
Boiling Point400.5±40.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 20601-85-8 |
| Catalog No. | 2A-2195668 |
| Chinese Name | Tetrahydromagnolol |
| Synonyms | MLO; 2,2'-dihydroxy-5,5'-dipropylbiphenyl; 5,5'-propyl-2,2'-dihydroxy-1,1'-biphenyl; 5,5'-Dipropyl-2,2'-biphenyldiol; 5.5'-Dipropyl-biphenyl-2.2'-diol; 5,5'-dipropylbiphenyl-2,2'-diol; tetrahydro-magnolol; 6,6'-Dihydroxy-3,3'-dipropyl-biphenyl |
| Molecular Formula | C18H22O2 |
| Molecular Weight | 270.37 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 400.5±40.0 °C at 760 mmHg |
| Storage Condition | -20°C, sealed, dry |
| Application | Tetrahydromagnolol (Magnolignan), the main metabolite of Magnolol, is a potent and selective cannabinoid CB2 receptor agonist with an EC50 of 170 nM and a Ki of 416 nM. Tetrahydromagnolol is 20 times |
| HTC | 2907299090 |
| PubChem ID | 24585465 |
| MDL Number | C18H22O2 |
| SMILES | CCCc1ccc(O)c(-c2cc(CCC)ccc2O)c1 |
| InChI | InChI=1S/C18H20O4/c1-2-3-14-10-13(5-7-17(14)21)16-9-12(4-6-18(16)22)8-15(20)11-19/h2,4-7,9-10,15,19-22H,1,3,8,11H2 |
| InChI Key | OYAQUBKYAKSHOA-UHFFFAOYSA-N |
| MSDS | msds/197388_1_20601_85_8.pdf |
| Use of | Tetrahydromagnolol (Magnolignan), a main metabolite of Magnolol, is a potent and selective cannabinoid CB2 receptor agonist with an EC50 of 170 nM and a Ki of 416 nM. Tetrahydromagnolol possesses 20-fold more selective for CB2 receptor than CB1 receptor. Tetrahydromagnolol is also a weak GPR55 receptor antagonist[1]. Properties Name 2-(2-hydroxy-5-propylphenyl)-4-propylphenol Synonym More Synonyms Tetrahydromagnolol Biological Activity Description Tetrahydromagnolol (Magnolignan), a main metabolite of Magnolol, is a potent and selective cannabinoid CB2 receptor agonist with an EC50 of 170 nM and a Ki of 416 nM. Tetrahydromagnolol possesses 20-fold more selective for CB2 receptor than CB1 receptor. Tetrahydromagnolol is also a weak GPR55 receptor antagonist[1]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> GPR55 Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor CB2:170 nM (EC50) CB2:416 nM (Ki) CB1:9010 nM (EC50) CB1:2260 nM (Ki) GPR55 receptor References Chemical & Physical Properties Molecular Formula C18H22O2 Exact Mass 270.161987 PSA 40.46000 Index of Refraction 1.577 InChIKey OYAQUBKYAKSHOA-UHFFFAOYSA-N Safety Information HS Code 2907299090 Synthetic Route 2,2'-dimeth... 860589-82-8 Tetrahydromagno... 20601-85-8 4-Propylphenol Tetrahydromagno... 20601-85-8 Literature: Kong, Zwe-Ling; Tzeng, Shin-Cheng; Liu, Yeuk-Chuen Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 163 - 166 1413440-39-7 2-Bromo-4-propy... 64080-16-6 Tetrahydromagno... 20601-85-8 Literature: Rempel, Viktor; Fuchs, Alexander; Hinz, Sonja; Karcz, Tadeusz; Lehr, Matthias; Koetter, Uwe; Mueller, Christa E. ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 1 p. 41 - 45 Precursor & DownStream Precursor 8 CAS#:860589-82-8 2,2'-dimethoxy-... CAS#:645-56-7 4-Propylphenol CAS#:1806-29-7 CAS#:4877-93-4 2,2'-dimethoxyb... DownStream 0 |
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