CAS Number70989-04-7
SynonymsS(+)-5-Ethyl-3-methyl-5-phenylhydantoin; S(+)-5-Ethyl-1-methyl-5-phenylbarbituric acid; S-mephenytoin; (+)-Mephobarbitol; 5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione; 5-éthyl-3-méthyl-5-phénylimidazolidine-2,4-dione; 5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione; (S)-Mephenytoin; mephenytoin; (5S)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione; UNII:R420KW629U; 5-Ethyl-3-methyl-5-phenylimidazolidin-2,4-dion; 2,4,6(1H,3H,5H)-Pyrimidinetrione,5-ethyl-1-methyl-5-phenyl-,(S); (+)-Mephobarbital; Gerot-Epilan; (5R)-mephobarbital; (S)-5-Ethyl-1-methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione; (S)-Methylphenobarbital; UNII-5NC67NU76B component ALARQZQTBTVLJV-ZDUSSCGKSA-N
Molecular FormulaC12H14N2O2
Molecular Weight218.25
Purity≥98 (HPLC)%
Density1.2±0.1 g/cm3
Melting Point135-138 °C
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 70989-04-7 |
| Catalog No. | 2A-2195610 |
| Chinese Name | 美芬妥英 |
| Synonyms | S(+)-5-Ethyl-3-methyl-5-phenylhydantoin; S(+)-5-Ethyl-1-methyl-5-phenylbarbituric acid; S-mephenytoin; (+)-Mephobarbitol; 5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione; 5-éthyl-3-méthyl-5-phénylimidazolidine-2,4-dione; 5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione; (S)-Mephenytoin; mephenytoin; (5S)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione; UNII:R420KW629U; 5-Ethyl-3-methyl-5-phenylimidazolidin-2,4-dion; 2,4,6(1H,3H,5H)-Pyrimidinetrione,5-ethyl-1-methyl-5-phenyl-,(S); (+)-Mephobarbital; Gerot-Epilan; (5R)-mephobarbital; (S)-5-Ethyl-1-methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione; (S)-Methylphenobarbital; UNII-5NC67NU76B component ALARQZQTBTVLJV-ZDUSSCGKSA-N |
| Molecular Formula | C12H14N2O2 |
| Molecular Weight | 218.25 |
| Purity | ≥98 (HPLC) |
| Density | 1.2±0.1 g/cm3 |
| Melting Point | 135-138 °C |
| Appearance | solid |
| Storage Condition | 2-8°C |
| Application | (S)-Mephenytoin (+)-Mephenytoin) is an anticonvulsant. (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. (S)-Mephenytoin can be used to analyze cytochrome P450 metabolism [1 |
| PubChem ID | 24724646 |
| MDL Number | MFCD00270025 |
| SMILES | CC[C@]1(NC(=O)N(C)C1=O)c2ccccc2 |
| InChI | 1S/C12H14N2O2/c1-3-12(9-7-5-4-6-8-9)10(15)14(2)11(16)13-12/h4-8H,3H2,1-2H3,(H,13,16)/t12-/m0/s1 |
| InChI Key | GMHKMTDVRCWUDX-LBPRGKRZSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12161501 |
| Hazard Symbols | transportation |
| MSDS | msds/197317_1_70989_04_7.pdf |
| Bioactivity | (S)-Mephenytoin ((+)-Mephenytoin) is an anticonvulsive agent. (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. (S)-Mephenytoin can be used for the analysis of cytochrome P450 metabolism[1][2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease In Vitro In the presence of cytochrome b5, the Km for S-mephenytoin is 1.25 mM with all five purified cytochrome P-450s preparations[1]. References [1]. Shimada T, et, al. Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction. J Biol Chem. 1986 Jan 15;261(2):909-21. [2]. Goldstein JA, et, al. Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans. Biochemistry. 1994 Feb 22;33(7):1743-52. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Melting Point 135-138ºC Molecular Formula C12H14N2O2 Molecular Weight 218.252 Exact Mass 218.105530 PSA 49.41000 LogP 1.40 Index of Refraction 1.541 InChIKey GMHKMTDVRCWUDX-LBPRGKRZSA-N SMILES CCC1(c2ccccc2)NC(=O)N(C)C1=O Storage condition 2-8°C |
| Use of | Properties Name (s)-mephenytoin Synonym More Synonyms (S)-Mephenytoin Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References Chemical & Physical Properties Molecular Formula C12H14N2O2 Exact Mass 218.105530 PSA 49.41000 Index of Refraction 1.541 InChIKey GMHKMTDVRCWUDX-LBPRGKRZSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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