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Home > Products > Pharmaceutical R&D Materials > Heterocyclic Building Blocks > 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione
3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione structure, CAS 425637-18-9

3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione

CAS Number425637-18-9

SynonymsSotrastaurin (AEB071); 3-(1H-Indol-3-yl)-4-[2-(4-methyl-1-piperazinyl)-4-quinazolinyl]-1H-pyrrole-2,5-dione; Sotrastaurin acetate; Sotrastaurin; AEB071; 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione; Kinome_2717

Molecular FormulaC25H22N6O2

Molecular Weight438.48

Purity≥98 (HPLC)%

Density1.4±0.1 g/cm3

Boiling Point

Melting Point

Flash Point

Appearancepowder

EINECS

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-2195385 Purity: ≥98 (HPLC)%
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Quality Control of [ 425637-18-9 ] Purity: ≥98 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number425637-18-9
Catalog No.2A-2195385
Chinese NameSotrastaurin
SynonymsSotrastaurin (AEB071); 3-(1H-Indol-3-yl)-4-[2-(4-methyl-1-piperazinyl)-4-quinazolinyl]-1H-pyrrole-2,5-dione; Sotrastaurin acetate; Sotrastaurin; AEB071; 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione; Kinome_2717
Molecular FormulaC25H22N6O2
Molecular Weight438.48
Purity≥98 (HPLC)
Density1.4±0.1 g/cm3
Appearancepowder
Storage Condition-20℃
ApplicationSotrastaurin is a potent pan-PKC inhibitor with Ki of 0.22 nM, 0.64 nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε respectively.
PubChem ID15303576
MDL NumberMFCD16038049
SMILESO=C(NC1=O)C(C2=CNC3=C2C=CC=C3)=C1C4=C5C=CC=CC5=NC(N6CCN(CC6)C)=N4
InChI1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
InChI KeyOAVGBZOFDPFGPJ-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC12352200
MSDSmsds/197082_1_425637_18_9.pdf
Transport InfoProduct Name: Sotrastaurin
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