CAS Number35920-39-9
Synonyms5'-Ethylcarboxamido Adenosine; MFCD00069195; 5'-Ethylcarboxamido Adenosine; 1-(6-AMINO-9H-PURIN-9-YL)-1-DEOXY-N-ETHYL-β-D-RIBOFURANURONAMIDE; 5'-(N-Ethylcarboxamido)adenosine; NECA
Molecular FormulaC12H16N6O4
Molecular Weight308.29
Density1.9±0.1 g/cm3
Melting Point229-231ºC
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 35920-39-9 |
| Catalog No. | 2A-1192584 |
| Chinese Name | 5'-N-乙基酰胺基腺苷 |
| Synonyms | 5'-Ethylcarboxamido Adenosine; MFCD00069195; 5'-Ethylcarboxamido Adenosine; 1-(6-AMINO-9H-PURIN-9-YL)-1-DEOXY-N-ETHYL-β-D-RIBOFURANURONAMIDE; 5'-(N-Ethylcarboxamido)adenosine; NECA |
| Molecular Formula | C12H16N6O4 |
| Molecular Weight | 308.29 |
| Density | 1.9±0.1 g/cm3 |
| Melting Point | 229-231ºC |
| Appearance | powder |
| Water Solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 m |
| Storage Condition | Sealed, store at 2 ºC -8 ºC |
| Packaging | I |
| Application | 5'-N-Ethylcarboxamidoadenosine (NECA) is a non-selective adenosine receptor agonist. |
| HTC | 2934999090 |
| PubChem ID | 24277684 |
| SMILES | CCNC(=O)C1OC(n2cnc3c(N)ncnc32)C(O)C1O |
| InChI Key | JADDQZYHOWSFJD-FLNNQWSLSA-N |
| Hazard Symbols | 6.1(a) |
| Bioactivity | 5'-N-Ethylcarboxamidoadenosine (NECA) is a nonselective adenosine receptor agonist. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Research Areas >> Cancer Research Areas >> Metabolic Disease Target Adenosine receptor[1] In Vivo After the administration of 5'-N-Ethylcarboxamidoadenosine (NECA), the mean number of cocaine infusions obtained per session is decreased significantly in a dose-dependent manner [5'-N-Ethylcarboxamidoadenosine (NECA): F(4,12)=14.9; P<0.001]. The administration of 5'-N-Ethylcarboxamidoadenosine (NECA) [F(4,12)=16.1; P<0.001] results in a significant increase in latencies above values obtained for vehicle treatment[1]. Daily i.p. injection of 5'-N-Ethylcarboxamidoadenosine (NECA) at 0.3 mg/kg/day for two weeks reduces malondialdehyde (MDA) levels in diabetic rats, but does not affect control rats. Daily treatment with NECA (0.3 mg/kg/day, i.p. for two weeks) reduces diabetes-induced gene expression of tumor necrosis factor (TNF)-α and interleukin (IL)-18 in diabetic rats, but does not affect control rats. Daily i.p. injection of 5'-N-Ethylcarboxamidoadenosine (NECA) at 0.3 mg/kg/day for two weeks also blocks the activation of JNK MAPK in diabetic rats, but does not affect control rats[2]. Animal Admin Male Wistar rats are used in this experiment. These animals range in weight between 350 and 425 g. They are housed individually in hanging wire cages under a 12-h light/dark cycle. The effects of 5'-N-Ethylcarboxamidoadenosine (NECA) are tested in four rats. In the experiment, either 5'-N-Ethylcarboxamidoadenosine (NECA) (5, 7.5, 10, 20 μg/kg) or vehicle (saline) is administered intraperitoneally 15 min prior to the start of test sessions. 5'-N-Ethylcarboxamidoadenosine (NECA) is administered following a random order crossover design. In most cases, animals are tested twice with the same dose[1]. References [1]. Knapp CM, et al. Adenosine agonists CGS 21680 and NECA inhibit the initiation of cocaine self-administration. Pharmacol Biochem Behav. 2001 Apr;68(4):797-803. [2]. Elsherbiny NM, et al. Reno-protective effect of NECA in diabetic nephropathy: implication of IL-18 and ICAM-1. Eur Cytokine Netw. 2012 Jul-Sep;23(3):78-86. Chemical & Physical Properties Density 1.9±0.1 g/cm3 Melting Point 229-231ºC Molecular Formula C12H16N6O4 Molecular Weight 308.293 Exact Mass 308.123291 PSA 148.41000 LogP -0.48 Index of Refraction 1.829 InChIKey JADDQZYHOWSFJD-FLNNQWSLSA-N SMILES CCNC(=O)C1OC(n2cnc3c(N)ncnc32)C(O)C1O Water Solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL Solutions may be stored for several days at 4?#x00b0;C. |
| Use of | 5'-N-Ethylcarboxamidoadenosine (NECA) is a nonselective adenosine receptor agonist. Properties Articles53 Name N-ethyl-5'-carboxamidoadenosine Synonym More Synonyms NECA Biological Activity Description 5'-N-Ethylcarboxamidoadenosine (NECA) is a nonselective adenosine receptor agonist. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Research Areas >> Cancer Research Areas >> Metabolic Disease Adenosine receptor[1] References [1]. Knapp CM, et al. Adenosine agonists CGS 21680 and NECA inhibit the initiation of cocaine self-administration. Pharmacol Biochem Behav. 2001 Apr;68(4):797-803. [2]. Elsherbiny NM, et al. Reno-protective effect of NECA in diabetic nephropathy: implication of IL-18 and ICAM-1. Eur Cytokine Netw. 2012 Jul-Sep;23(3):78-86. Chemical & Physical Properties Molecular Formula C12H16N6O4 Exact Mass 308.123291 PSA 148.41000 LogP -0.48 Index of Refraction 1.829 InChIKey JADDQZYHOWSFJD-FLNNQWSLSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (5'-(N-Ethylcarboxamido)adenosine) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (5'-(N-Ethylcarboxamido)adenosine) International air transport hazard regulations: Toxic solid, organic, n.o.s. (5'-(N-Ethylcarboxamido)adenosine) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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