| Chemical & Physical Properties | |
|---|---|
| CAS Number | 246852-12-0 |
| Catalog No. | 2A-1192580 |
| Chinese Name | 甲磺酸氨氯地平 |
| Synonyms | Norvasc; UNII-291Y33EZHA; Amlodipine Mesilate; Amlodipine Mesylate; UNII:291Y33EZHA |
| Molecular Formula | C21H29ClN2O8S |
| Molecular Weight | 504.982 |
| Purity | 98.00 |
| Appearance | solid |
| Storage Condition | 2-8°C, inert gas, dry, sealed |
| Application | Amlodipine mesylate is an antianginal drug and an orally active dihydropyridine calcium channel blocker that acts by blocking voltage-dependent L-type calcium channels, thereby inhibiting the initial |
| HTC | 2933399090 |
| SMILES | CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl.CS(=O)(=O)O |
| InChI Key | MUVFCHUBATVFPP-UHFFFAOYSA-N |
| Use of | Amlodipine mesylate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine mesylate can be used for the research of high blood pressure and cancer[1][2][3]. Properties Name 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate,methanesulfonic acid Synonym More Synonyms Norvasc Biological Activity Description Amlodipine mesylate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine mesylate can be used for the research of high blood pressure and cancer[1][2][3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cancer Research Areas >> Cardiovascular Disease L-type calcium channel References [1]. Kishen G. Bulsara, et al. Amlodipine. [2]. Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586. [4]. Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87. Chemical & Physical Properties Exact Mass 504.133301 PSA 162.63000 LogP 3.88020 InChIKey MUVFCHUBATVFPP-UHFFFAOYSA-N Safety Information Hazard Codes Xn HS Code 2933399090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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