CAS Number26098-04-4
SynonymsGeneticin C1a; Gentamicin C1a Pentaacetate Salt; GentaMycin C1a Acetate; Gentamycin C1a; GentaMicin C3 Acetate; Gentamisin C3; Gentamicin D; Gentamicin C1a; GentaMicin D Acetate; Gentamicin C3
Molecular FormulaC19H39N5O7
Molecular Weight449.54200
Density1.36g/cm3
Boiling Point675.2ºC at 760 mmHg
Melting Point102-108ºC
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 26098-04-4 |
| Catalog No. | 2A-1192479 |
| Chinese Name | 庆大霉素C1a |
| Synonyms | Geneticin C1a; Gentamicin C1a Pentaacetate Salt; GentaMycin C1a Acetate; Gentamycin C1a; GentaMicin C3 Acetate; Gentamisin C3; Gentamicin D; Gentamicin C1a; GentaMicin D Acetate; Gentamicin C3 |
| Molecular Formula | C19H39N5O7 |
| Molecular Weight | 449.54200 |
| Density | 1.36g/cm3 |
| Boiling Point | 675.2ºC at 760 mmHg |
| Melting Point | 102-108ºC |
| Storage Condition | -20°C, dry |
| Application | Gentamicin C1a is the precursor of the semi-synthetic antibiotic atimicin and has antibacterial activity. Gentamicin C1a is the main component of the gentamicin complex [1][2]. |
| HTC | 3004909090 |
| SMILES | CNC1C(O)C(OC2C(N)CC(N)C(OC3OC(CN)CCC3N)C2O)OCC1(C)O |
| InChI Key | VEGXETMJINRLTH-BOZYPMBZSA-N |
| Use of | Gentamicin C1a is the precursor of the semi-synthetic antibiotic Etimicin, and has antibacterial activity. Gentamicin C1a is the major component of the Gentamicin complex[1][2]. Properties Name gentamycin C1a Synonym More Synonyms gentamycin C1a Biological Activity Description Gentamicin C1a is the precursor of the semi-synthetic antibiotic Etimicin, and has antibacterial activity. Gentamicin C1a is the major component of the Gentamicin complex[1][2]. Related Catalog Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial References [1]. Li D, et al. Construction of a gentamicin C1a-overproducing strain of Micromonospora purpurea by inactivation of the gacD gene. Microbiol Res. 2013 Jun 12;168(5):263-7. [2]. Ishikawa M, et al. Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use. Sci Rep. 2019 Feb 20;9(1):2410. [3]. Isoherranen N, et al. Pharmacokinetics of gentamicin C(1), C(1a), and C(2) in beagles after a single intravenous dose. Antimicrob Agents Chemother. 2000 Jun;44(6):1443-7. Chemical & Physical Properties Molecular Formula C19H39N5O7 Exact Mass 449.28500 PSA 213.72000 Index of Refraction 1.603 InChIKey VEGXETMJINRLTH-BOZYPMBZSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopy ranosyl-(1-6)-O-(2,6- diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyrano syl-(1-4))-2-deoxy- CAS REGISTRY NUMBER : 26098-04-4 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C19-H39-N5-O7 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T6OTJ CQ DM1 EQ E1 BO- BL6TJ AZ CQ EZ DO- BT6OTJ CZ F1Z HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,239,1977 Safety Information Hazard Codes Xn HS Code 3004909090 Synthetic Route Total: 1 Page CAS#:32385-11-8 gentamycin C1a CAS#:26098-04-4 Micronomicin CAS#:52093-21-7 Literature: Agricultural and Biological Chemistry, , vol. 46, # 2 p. 515 - 522 Precursor & DownStream Precursor 1 CAS#:32385-11-8 DownStream 0 |
| Transport Info | Product name: Gentamicin C1a |
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