CAS Number84-82-2
SynonymsToxoflavin; 1,6-Dimethyl-1H-pyrimido[5,4-e][1,2,4]triazin-5,7-dion; 1,6-dimethylpyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione; Xanthotricin; Xanthothricin (VAN); Toxoflavine; Xanthothricin; 1,6-dimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione; GNF-Pf-67
Molecular FormulaC7H7N5O2
Molecular Weight193.16
Density1.65g/cm3
Boiling Point276.7ºC at 760 mmHg
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 84-82-2 |
| Catalog No. | 2A-1191725 |
| Chinese Name | 毒黄素 |
| Synonyms | Toxoflavin; 1,6-Dimethyl-1H-pyrimido[5,4-e][1,2,4]triazin-5,7-dion; 1,6-dimethylpyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione; Xanthotricin; Xanthothricin (VAN); Toxoflavine; Xanthothricin; 1,6-dimethyl-1H-pyrimido[5,4-e][1,2,4]triazine-5,7-dione; GNF-Pf-67 |
| Molecular Formula | C7H7N5O2 |
| Molecular Weight | 193.16 |
| Density | 1.65g/cm3 |
| Boiling Point | 276.7ºC at 760 mmHg |
| Storage Condition | -20°C, sealed, dry |
| Application | Toxoflavin (Xanthothricin) is a TCF4/β-catenin complex inhibitor and a KDM4A inhibitor with anti-tumor activity. |
| HTC | 2933990090 |
| PubChem ID | 329817147 |
| MDL Number | MFCD00459812 |
| SMILES | Cn1ncnc2c(=O)n(C)c(=O)nc1-2 |
| InChI | InChI=1S/C7H7N5O2/c1-11-6(13)4-5(10-7(11)14)12(2)9-3-8-4/h3H,1-2H3 |
| InChI Key | SLGRAIAQIAUZAQ-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| Bioactivity | Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity[1][2]. Related Catalog Research Areas >> Cancer Target TCF4/β-catenin[1], KDM4A[2] In Vitro Toxoflavin (Xanthothricin) exhibits dose-dependent cytotoxicity against the 3 hepatoma cell lines, and with IC50s of 0.66 μM, 0.36 μM and 0.98 μM for Hep40 cells, HepG2 cells and Huh7 cells respectively[1]. References [1]. Wei W, et al. Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo. Int J Cancer. 2010 May 15;126(10):2426-36. [2]. Franci G, et al. Identification and characterization of PKF118-310 as a KDM4A inhibitor. Epigenetics. 2017 Mar 4;12(3):198-205. Chemical & Physical Properties Density 1.65g/cm3 Boiling Point 276.7ºC at 760 mmHg Molecular Formula C7H7N5O2 Molecular Weight 193.16300 Flash Point 121.1ºC Exact Mass 193.06000 PSA 82.67000 Index of Refraction 1.76 InChIKey SLGRAIAQIAUZAQ-UHFFFAOYSA-N SMILES Cn1ncnc2c(=O)n(C)c(=O)nc1-2 |
| Use of | Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity[1][2]. Properties Articles24 Name 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7-dione Synonym More Synonyms Toxoflavin Biological Activity Description Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex, also acts as an inhibitor of KDM4A, with antitumor activity[1][2]. Related Catalog Research Areas >> Cancer References [2]. Franci G, et al. Identification and characterization of PKF118-310 as a KDM4A inhibitor. Epigenetics. 2017 Mar 4;12(3):198-205. Chemical & Physical Properties Molecular Formula C7H7N5O2 Exact Mass 193.06000 PSA 82.67000 Index of Refraction 1.76 InChIKey SLGRAIAQIAUZAQ-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (PKF118-310) International Maritime Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (PKF118-310) International air transport hazard regulations: Toxic solid, organic, n.o.s. (PKF118-310) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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