CAS Number2196-14-7
Synonyms7,4'-Dihydroxyflavanone; 7,4'-Dihydroxyflavone; FLAVONE,4',7-DIHYDROXY; 7-Hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; 7-hydroxy-2-(4-hydroxyphenyl)chromen-4-one; 4',7-Dihydroxyflavone
Molecular FormulaC15H10O4
Molecular Weight254.24
Density1.4±0.1 g/cm3
Boiling Point512.8±50.0 °C at 760 mmHg
Melting Point324-325ºC
Appearanceyellow powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2196-14-7 |
| Catalog No. | 2A-1190894 |
| Chinese Name | 7,4'-二羟基黄酮 |
| Synonyms | 7,4'-Dihydroxyflavanone; 7,4'-Dihydroxyflavone; FLAVONE,4',7-DIHYDROXY; 7-Hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; 7-hydroxy-2-(4-hydroxyphenyl)chromen-4-one; 4',7-Dihydroxyflavone |
| Molecular Formula | C15H10O4 |
| Molecular Weight | 254.24 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 512.8±50.0 °C at 760 mmHg |
| Melting Point | 324-325ºC |
| Appearance | yellow powder |
| Storage Condition | 2-8℃, dry, sealed |
| Application | 7,4'-Dihydroxyflavone (7,4'-DHF) 7,4'-Dihydroxyflavone is a flavonoid isolated from licorice Glycyrrhiza uralensis. It is an eotaxin/CCL11 inhibitor and inhibits the production of eotaxin. 7,4'-Dihydr |
| HTC | 2914501900 |
| PubChem ID | 14270 |
| MDL Number | MFCD00017694 |
| SMILES | O=c1cc(-c2ccc(O)cc2)oc2cc(O)ccc12 |
| InChI | InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-8,16-17H |
| InChI Key | LCAWNFIFMLXZPQ-UHFFFAOYSA-N |
| Use of | 7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM[1]. Properties Name 4',7-dihydroxyflavone Synonym More Synonyms 4',7-Dihydroxyflavone Biological Activity Description 7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM[1]. Related Catalog Signaling Pathways >> GPCR/G Protein >> CCR Signaling Pathways >> Immunology/Inflammation >> CCR Research Areas >> Inflammation/Immunology IC50: 1.4 μM (NCI-H292 human airway epithelial cell) (7,4'-Dihydroxyflavone)[2] References [1]. Liu C, et al. The Flavonoid 7,4'-Dihydroxyflavone Prevents Dexamethasone Paradoxical Adverse Effect on Eotaxin Production by Human Fibroblasts. Phytother Res. 2017 Mar;31(3):449-458. [2]. Liu C, et al. The Flavonoid 7,4'-Dihydroxyflavone Inhibits MUC5AC Gene Expression, Production, and Secretion via Regulation of NF-κB, STAT6, and HDAC2. Phytother Res. 2015 Jun;29(6):925-32. Chemical & Physical Properties Molecular Formula C15H10O4 Exact Mass 254.057907 PSA 70.67000 Index of Refraction 1.699 InChIKey LCAWNFIFMLXZPQ-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Flavone, 4',7-dihydroxy- CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C15-H10-O4 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T66 BO EVJ CR DQ& IQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 100 ug/plate REFERENCE : ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,401,1981 Safety Information Hazard Codes Xi HS Code 2914501900 Synthetic Route Ethylparaben 4',7-Dihydr... Literature: Ayabe, Shin-Ichi; Kobayashi, Miyuki; Hikichi, Manabu; Matsumoto, Kazuo; Furuya, Tsutomu Phytochemistry (Elsevier), 1980 , vol. 19, p. 2179 - 2184 4-(benzyloxy)be... 4',7-Dihydr... Literature: Ayabe, Shin-Ichi; Kobayashi, Miyuki; Hikichi, Manabu; Matsumoto, Kazuo; Furuya, Tsutomu Phytochemistry (Elsevier), 1980 , vol. 19, p. 2179 - 2184 4-(Benzyloxy)be... 4',7-Dihydr... Literature: Ayabe, Shin-Ichi; Kobayashi, Miyuki; Hikichi, Manabu; Matsumoto, Kazuo; Furuya, Tsutomu Phytochemistry (Elsevier), 1980 , vol. 19, p. 2179 - 2184 |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Product name: Summary 2914501900 other ketone-phenols. Supervision conditions:None. VAT: 17.0%. Tax rebate rate:9.0%. MFN tariff:5.5%. General tariff:30.0% |
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