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4-HYDROXYCHALCONE structure, CAS 20426-12-4

4-HYDROXYCHALCONE

CAS Number20426-12-4

Synonyms4-HYDROXYCHALCONE; MFCD00016488; HYDROXYCHALCONE,4

Molecular FormulaC15H12O2

Molecular Weight224.26

Purity

Density

Boiling Point

Melting Point180-184 °C

Flash Point

Appearance

EINECS

MSDSChineseEnglish

Symbol9.0

Signal WordWarning

Cat. No.: 2A-1189952 Purity:
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Quality Control of [ 20426-12-4 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number20426-12-4
Catalog No.2A-1189952
Chinese Name4-羟基查耳酮
Synonyms4-HYDROXYCHALCONE; MFCD00016488; HYDROXYCHALCONE,4
Molecular FormulaC15H12O2
Molecular Weight224.26
Melting Point180-184 °C
Storage ConditionKeep receptacles sealed Place in a tight container
Application4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone inhibits angiogenesis by inhibiting growth factor pathways without signs of cytotoxi
HTC2914501900
PubChem ID442764
MDL NumberMFCD00016488
SMILESOc1ccc(cc1)/C=C/C(=O)c2ccccc2
InChIInChI=1S/C15H12O2/c16-14-9-6-12(7-10-14)8-11-15(17)13-4-2-1-3-5-13/h1-11,16H/b11-8+
InChI KeyInChIKey=PWWCDTYUYPOAIU-DHZHZOJOSA-N
Hazard Symbols9.0
Bioactivity4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2]. Related Catalog Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Target NF-κB[2] References [1]. Varinska L, et al. Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. Eur J Pharmacol. 2012 Sep 15;691(1-3):125-33. [2]. Qu Q, et al. 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. Biomed Res Int. 2014;2014:603415. Chemical & Physical Properties Melting Point 180-184 °C Molecular Formula C15H12O2 Molecular Weight 224.25500 Exact Mass 224.08400 PSA 37.30000 LogP 3.28830
Use of4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2]. Properties Name 4-hydroxychalcone Synonym More Synonyms 4-Hydroxychalcone Biological Activity Description 4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2]. Related Catalog Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology References [1]. Varinska L, et al. Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. Eur J Pharmacol. 2012 Sep 15;691(1-3):125-33. [2]. Qu Q, et al. 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. Biomed Res Int. 2014;2014:603415. Chemical & Physical Properties Molecular Formula C15H12O2 Exact Mass 224.08400 PSA 37.30000 LogP 3.28830
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Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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